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カタログ番号 | 製品名 | 別名 | ターゲット |
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T8561 | Apcin | APC | |
Apcin is a potent and competitive inhibitor of anaphase-promoting complex/cyclosome (APC/C(Cdc20)) E3 ligase activity. Apcin competitively inhibits APC/C-dependent ubiquitylation by binding to Cdc20 and preventing substr... | |||
T39710 | ARV-471 | Vepdegestrant | Estrogen Receptor/ERR |
ARV-471 (Vepdegestrant) is a orally active Cereblon -based estrogen receptor (ER) PROTAC degrader. ARV-471 is developed for the research of breast cancer. | |||
T3110 | PRT4165 | NSC600157,PRT 4165 | BMI-1 , Others , E1/E2/E3 Enzyme |
PRT4165 (NSC600157) is a potent PRC1-mediated H2A ubiquitylation inhibitor. | |||
T25465 | GS143 | GS-143,GS 143 | IκB/IKK , E1/E2/E3 Enzyme , NF-κB |
GS143 is a selective IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. GS143 suppresses NF-κB activation and transcription of target genes and does not inhibit protea... | |||
T61512 | FT3967385 | ||
FT3967385 is a newly developed compound that functions as a USP30 inhibitor, emulating the genetic deficiency of USP30. This inhibition serves as a catalyst for the amplification of mitochondrial ubiquitylation through t... | |||
T69642 | FT385 | ||
FT385 is a novel USP30 inhibitor, recapitulating genetic loss of USP30 and setting the trigger for PINK1-PARKIN amplification of mitochondrial ubiquitylation. | |||
T75133 | NRX-0492 | ||
NRX-0492 is an orally administered compound that efficiently degrades Bruton's tyrosine kinase (BTK) by catalyzing its ubiquitylation and subsequent proteasomal degradation, achieving half-maximal degradation concentrati... |
カタログ番号 | 製品名 | Species | Expression System |
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TMPY-00611 | UBE2B Protein, Mouse, Recombinant | Mouse | E. coli |
The ubiquitin-conjugating enzyme E2B (Ube2b) is a critical target gene of androgen receptor (AR), mediating the function of AR in spermatogenesis by promoting H2A ubiquitylation. Moreover, UBE2B plays an important role i... | |||
TMPJ-01386 | STUB1 Protein, Human, Recombinant | Human | E. coli |
E3 Ubiquitin-Protein Ligase CHIP is a cytoplasmic protein. CHIP is highly expressed in skeletal muscle, heart, pancreas, brain and placenta. CHIP interacts with the molecular chaperones Hsc70-Hsp70 and Hsp90 through its ... | |||
TMPY-02522 | OTUB2 Protein, Human, Recombinant (His) | Human | E. coli |
Otubain 2 (OTUB2) is a member of DUBs that belong to the ovarian tumour (OTU) superfamily of proteins which consists of a five-stranded β-sheet sandwiched in between a small helical amino-terminal region consisting of α1... | |||
TMPY-02496 | Rad6/UBE2A Protein, Human, Recombinant (His) | Human | E. coli |
Ubiquitin-conjugating enzyme E2 A (also known as HHR6A or UBE2A), encoded by human DNA repair genes HHR6A, belongs to the ubiquitin-conjugating enzymes (E2 enzymes) family and is likely to be involved in postreplication ... | |||
TMPY-02510 | HIST2H2BE Protein, Human, Recombinant | Human | E. coli |
Histones are a complex family of highly conserved basic proteins responsible for packaging chromosomal DNA into nucleosomes. Histone proteins exhibit two levels of diversity: 1. evolutionary diversity between species and... | |||
TMPY-04813 | ACAT2 Protein, Rat, Recombinant (His) | Rat | E. coli |
Acyl-coenzyme A: cholesterol acyltransferase (ACAT) is an intracellular enzyme that produces cholesteryl esters in various tissues. In mammals, two ACAT genes (ACAT1 and ACAT2) have been identified. Together, these two e... |
カタログ番号 | 製品名 | ||
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L3500 | Histone Modification Compound Library | 469 compounds | |
A unique collection of 469 histone modification related compounds for high throughput screening (HTS) and high content screening (HCS); |