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Search Results for " ubiquitylation "

ターゲット

7

阻害剤

6

リコンビナントタンパク質

1

ライブラリー

カタログ番号 製品名 別名 ターゲット
T8561 Apcin APC
Apcin is a potent and competitive inhibitor of anaphase-promoting complex/cyclosome (APC/C(Cdc20)) E3 ligase activity. Apcin competitively inhibits APC/C-dependent ubiquitylation by binding to Cdc20 and preventing substr...
T39710 ARV-471 Vepdegestrant Estrogen Receptor/ERR
ARV-471 (Vepdegestrant) is a orally active Cereblon -based estrogen receptor (ER) PROTAC degrader. ARV-471 is developed for the research of breast cancer.
T3110 PRT4165 NSC600157,PRT 4165 BMI-1 , Others , E1/E2/E3 Enzyme
PRT4165 (NSC600157) is a potent PRC1-mediated H2A ubiquitylation inhibitor.
T25465 GS143 GS-143,GS 143 IκB/IKK , E1/E2/E3 Enzyme , NF-κB
GS143 is a selec­tive IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. GS143 sup­presses NF-κB acti­va­tion and tran­scrip­tion of tar­get genes and does not inhibit protea...
T61512 FT3967385
FT3967385 is a newly developed compound that functions as a USP30 inhibitor, emulating the genetic deficiency of USP30. This inhibition serves as a catalyst for the amplification of mitochondrial ubiquitylation through t...
T69642 FT385
FT385 is a novel USP30 inhibitor, recapitulating genetic loss of USP30 and setting the trigger for PINK1-PARKIN amplification of mitochondrial ubiquitylation.
T75133 NRX-0492
NRX-0492 is an orally administered compound that efficiently degrades Bruton's tyrosine kinase (BTK) by catalyzing its ubiquitylation and subsequent proteasomal degradation, achieving half-maximal degradation concentrati...

Recombinant Proteins

カタログ番号 製品名 Species Expression System
TMPY-00611 UBE2B Protein, Mouse, Recombinant Mouse E. coli
The ubiquitin-conjugating enzyme E2B (Ube2b) is a critical target gene of androgen receptor (AR), mediating the function of AR in spermatogenesis by promoting H2A ubiquitylation. Moreover, UBE2B plays an important role i...
TMPJ-01386 STUB1 Protein, Human, Recombinant Human E. coli
E3 Ubiquitin-Protein Ligase CHIP is a cytoplasmic protein. CHIP is highly expressed in skeletal muscle, heart, pancreas, brain and placenta. CHIP interacts with the molecular chaperones Hsc70-Hsp70 and Hsp90 through its ...
TMPY-02522 OTUB2 Protein, Human, Recombinant (His) Human E. coli
Otubain 2 (OTUB2) is a member of DUBs that belong to the ovarian tumour (OTU) superfamily of proteins which consists of a five-stranded β-sheet sandwiched in between a small helical amino-terminal region consisting of α1...
TMPY-02496 Rad6/UBE2A Protein, Human, Recombinant (His) Human E. coli
Ubiquitin-conjugating enzyme E2 A (also known as HHR6A or UBE2A), encoded by human DNA repair genes HHR6A, belongs to the ubiquitin-conjugating enzymes (E2 enzymes) family and is likely to be involved in postreplication ...
TMPY-02510 HIST2H2BE Protein, Human, Recombinant Human E. coli
Histones are a complex family of highly conserved basic proteins responsible for packaging chromosomal DNA into nucleosomes. Histone proteins exhibit two levels of diversity: 1. evolutionary diversity between species and...
TMPY-04813 ACAT2 Protein, Rat, Recombinant (His) Rat E. coli
Acyl-coenzyme A: cholesterol acyltransferase (ACAT) is an intracellular enzyme that produces cholesteryl esters in various tissues. In mammals, two ACAT genes (ACAT1 and ACAT2) have been identified. Together, these two e...
カタログ番号 製品名
L3500 Histone Modification Compound Library

469 compounds
A unique collection of 469 histone modification related compounds for high throughput screening (HTS) and high content screening (HCS);