ペプチド
抗体
色素試薬
PROTAC
バーチャルスクリーニング
TargetMolキット
Cell Counting Kit-8 (CCK-8)
Inhibitor Cocktails
天然化合物
フェノール類
アルカロイド類
フラボノイド類
阻害剤
血管新生
アポトーシス
オートファジー
細胞周期・チェックポイント
クロマチン・エピジェネティック
細胞骨格シグナル
DNA損傷・DNA修復
内分泌・ホルモン
GPCR/Gタンパク質
免疫・炎症
JAK・STATシグナル
| Cat. No. | 製品名 | CAS No. | Purity | Chemical Structure |
|---|---|---|---|---|
| T21544 | AZD-5597 | 924641-59-8 | 98% |
|
| AZD-5597 is a potent imidazole pyrimidine amide CDK inhibitor. | ||||
| T4618 | BGG463 | 890129-26-7 | 98% |
|
| BGG463 can inhibit c-ABL-T334I, BCR-ABL and BCR-ABL-T315I variants with a 50% inhibitory concentration (IC50) of 0.25 μM, 0.09 μM and 0.590 μM, respectively. | ||||
| T60619 | CDK9-IN-15 | 852678-17-2 | 98% |
|
| CDK9-IN-15 is a potent small molecule CDK9 inhibitor, which can block the phosphorylation of positive transcription elongation factor b (P-TEFb) on the C-termina... | ||||
| T6057 | URMC-099 | 1229582-33-5 | 98% |
|
| URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM)... | ||||
| T3589 | NSC23005 Sodium | 1796596-46-7 | 98% |
|
| NSC23005 sodium is a novel and effective p18 inhibitor (ED50=5.21 nM) in promoting Hematopoietic stem cells (HSCs) expansion in both murine and human models. | ||||
| T16021 | MBQ-167 | 2097938-73-1 | 98% |
|
| MBQ-167 is a dual inhibitor of Rac/Cdc42 (IC50s: 103 nM for Rac 1/2/3 and 78 nM for Cdc42 in MDA-MB-231 cells, respectively). | ||||
| T3590 | NSC23005 | 6314-70-1 | 98% |
|
| NSC23005 sodium is a p18INK inhibitor with potently promoted hematopoietic stem cell (HSC) expansion (ED50: 5.21 nM). | ||||
| T8230 | PNU112455A hydrochloride | 21886-12-4 | 98% |
|
| PNU 112455A is an ATP site competetive inhibitor of CDK2 and CDK5,binds to the ATP site of CDK2 and CDK5 with Kms of 3.6 and 3.2 μM, respectively. | ||||
| T9971 | WAY-647802 | 852225-20-8 | 98% |
|
| WAY-647802 is a CDK inhibitor. | ||||
| T16784 | Roniciclib | 1223498-69-8 | 98% |
|
| Roniciclib is a potent pan-CDK inhibitor and a novel oral cytotoxic agent. Roniciclib inhibits the activity of cell-cycle CDKs CDK1, CDK2, CDK3, CDK4, and of tra... | ||||
| T6240 | Palbociclib Isethionate | 827022-33-3 | 98% |
|
| Palbociclib (PD-0332991) is a selective inhibitor of CDK4/6 (IC50s: 11/16 nM). It exhibits no inhibition against a panel of 36 additional protein kinases. | ||||
| T9615 | CK7 | 507487-89-0 | 98% |
|
| CK7, a Cdk2/9 inhibitor, can be used for the synthesis of Nek1 inhibitor BSc5231 and BSc5367. | ||||
| T3664 | THZ1 | 1604810-83-4 | 98% |
|
| THZ1 is a novel selective and potent covalent CDK7 inhibitor. | ||||
| T6052 | GW 441756 | 504433-23-2 | 98% |
|
| GW 441756 is a specific Tropomyosin-related kinase A (TrkA) inhibitor with an IC50 value of 2 nM. | ||||
| T8484 | JSH-150 | 2247481-21-4 | 98% |
|
| JSH-150 is a highly selective CDK9 inhibitor(IC50 : 1 nM). | ||||
| T16359 | NU6140 | 444723-13-1 | 98% |
|
| NU6140 is a selective inhibitor of CDK2-cyclin A (IC50, 0.41 μM). It shows 10- to 36-fold selectivity over other CDKs. NU6140 also effectively inhibits Aurora A ... | ||||
| T14072 | A-443654 | 552325-16-3 | 98% |
|
| A-443654 is a pan-Akt inhibitor. It has equal potency against Akt1, Akt2, or Akt3 within cells (Ki=160 pM). | ||||
| T6028 | PF 477736 | 952021-60-2 | 98% |
|
| PF-477736 is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (CSF1R), Ret and Yes. | ||||
| T16363 | NVP-2 | 1263373-43-8 | 98% |
|
| NVP-2 is an effective and selective ATP-competitive cyclin-dependent kinase 9 (CDK9) probe. NVP-2 induces cell apoptosis. NVP-2 inhibits CDK9/CycT activity (IC50... | ||||
| T23840 | BUR1 | 23000-46-6 | 98% |
|
| BUR1 is a selective BMP upregulator that acts by increasing the expression of Inhibitor of DNA binding 1 and inducing BMP2 and PTGS2 expression. | ||||
