HDAC

Histone deacetylases (HDAC) are a class of enzymes that remove acetyl groups (O=C-CH3) from an ε-N-acetyl lysine amino acid on a histone, allowing the histones to wrap the DNA more tightly. This is important because DNA is wrapped around histones, and DNA expression is regulated by acetylation and de-acetylation. Its action is opposite to that of histone acetyltransferase. HDAC proteins are now also called lysine deacetylases (KDAC), to describe their function rather than their target, which also includes non-histone proteins.

Cat. No.	製品名	CAS No.	Purity
T1819	Nexturastat A	1403783-31-2	98%
T1819	Nexturastat A is an effective and specific HDAC6 inhibitor (IC50: 5 nM). Its selectivity is >190-fold than other HDACs.
T9745	Elevenostat	1454902-97-6	98%
T9745	Elevenostat is an HDAC11-selective inhibitor with an IC50 value of 0.235 µM.
T3206	NKL 22	537034-15-4	98%
T3206	NKL 22 (Histone Deacetylase Inhibitor IV) is an effective Histone Deacetylase Inhibitor.
TQ0074	ACY-775	1375466-18-4	98%
TQ0074	ACY-775 is an effective and specific inhibitor of HDAC6 (IC50: 7.5 nM).
T3204	BML-210	537034-17-6	98%
T3204	BML-210 (CAY10433) is a new-type HDAC inhibitor.
T9963	MPT0B390	1817802-18-8	98%
T9963	MPT0B390 is an inhibitor of HDAC and a TIMP3 inducer inhibiting tumor growth, metastasis, and angiogenesis.
T16129	MPI_5a	1259296-46-2	98%
T16129	MPI_5a is an effective and selective inhibitor of HDAC6 (IC50=36 nM). MPI_5a weakly inhibits other HDAC isoforms and it also inhibits acyl-tubulin accumulation i...
T37427	(2R/S)-6-PNG	68682-01-9	98%
T37427	(2R/S)-6-PNG (6-Prenylnaringenin) is a novel natural histone deacetylase inhibitor with anticancer and antitumor activity, and blocks T-type calcium channels to ...
T14947	CHDI-390576	1629729-98-1	98%
T14947	CHDI-390576 is a CNS penetrant class IIa HDAC inhibitor (IC50s: 54 nM, 60 nM, 31 nM, 50 nM for class IIa HDAC4, HDAC5, HDAC7, HDAC9). It shows >500-fold selectiv...
T1857	TMP269	1314890-29-3
T1857	TMP269 is an effective, specific class IIa HDAC inhibitor for HDAC4 (IC50: 157 nM), HDAC5 (IC50: 97 nM), HDAC7 (IC50: 43 nM), and HDAC9 (IC50: 23 nM), respective...
T9041	AES-350	847249-57-4
T9041	AES-350 is a potent and orally active HDAC6 inhibitor(IC50 and a Ki of 0.0244 μM and 0.035 μM, respectively). It is also against HDAC-3, -8, and -11 in an enzyma...
T2294	BG45	926259-99-6
T2294	BG45 is an HDAC I type inhibitor with IC50 of 289 nM, 2.0 μM, 2.2 μM and >20 μM for HDAC3/1/2/6 in cell-free assays, respectively.
T6055	Quisinostat	875320-29-9
T6055	Quisinostat (JNJ-26481585) (JNJ-26481585) is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM, modest potent to HDACs...
T16545	Pivanex	122110-53-6
T16545	Pivanex (Pivalyloxymethyl butyrate) is an orally active HDAC inhibitor and an antimetastatic and antiangiogenic agent. Pivanex downregulates the Bcr-Abl protein ...
T21505	Suberoyl bis-hydroxamic acid	38937-66-5
T21505	Suberoyl bis-hydroxamic acid (SBHA) is a Histone deacetylase (HDAC) inhibitor. HDAC is required for transcriptional modulation, cell cycle regulation and develop...
T6S0033	Crotonoside	1818-71-9
T6S0033	1. Crotonoside (Isoguanosine) has much more active than adenosine in reducing the blood pressure in rabbits and cats, in decreasing the tone of isolated intestin...
T21551	2-hexyl-4-Pentynoic Acid	96017-59-3
T21551	2-hexyl-4-Pentynoic Acid, a valproic acid (VPA) derivatives, is a potent and robust HDACs inhibitor with IC50 value of 13 μM.
T2023	MC1568	852475-26-4
T2023	MC1568 is a specific HDAC inhibitor for maize HD1-A (IC50: 100 nM, in a cell-free assay). It is 34-fold more selective for HD1-A than HD1-B.
T3193	Pimelic diphenylamide 106	937039-45-7
T3193	Pimelic diphenylamide 106 (RGFA-8) is a slow, tight-binding inhibitor of class I HDAC (with IC50 values of 150 nM , 760 nM and 370 nM for HDAC 1, 2, and 3, respe...
T5830	SKLB-23bb	1815580-06-3
T5830	SKLB-23bb is an orally bioavailable HDAC6-selective inhibitor and also has microtubule-disrupting ability.