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HDAC

Histone deacetylases (HDAC) are a class of enzymes that remove acetyl groups (O=C-CH3) from an ε-N-acetyl lysine amino acid on a histone, allowing the histones to wrap the DNA more tightly. This is important because DNA is wrapped around histones, and DNA expression is regulated by acetylation and de-acetylation. Its action is opposite to that of histone acetyltransferase. HDAC proteins are now also called lysine deacetylases (KDAC), to describe their function rather than their target, which also includes non-histone proteins.
Cat. No. 製品名 CAS No. Purity Chemical Structure
T1819 Nexturastat A 1403783-31-2 98%
Nexturastat A is an effective and specific HDAC6 inhibitor (IC50: 5 nM). Its selectivity is >190-fold than other HDACs.
T9745 Elevenostat 1454902-97-6 98%
Elevenostat is an HDAC11-selective inhibitor with an IC50 value of 0.235 µM.
T3206 NKL 22 537034-15-4 98%
NKL 22 (Histone Deacetylase Inhibitor IV) is an effective Histone Deacetylase Inhibitor.
TQ0074 ACY-775 1375466-18-4 98%
ACY-775 is an effective and specific inhibitor of HDAC6 (IC50: 7.5 nM).
T3204 BML-210 537034-17-6 98%
BML-210 (CAY10433) is a new-type HDAC inhibitor.
T9963 MPT0B390 1817802-18-8 98%
MPT0B390 is an inhibitor of HDAC and a TIMP3 inducer inhibiting tumor growth, metastasis, and angiogenesis.
T16129 MPI_5a 1259296-46-2 98%
MPI_5a is an effective and selective inhibitor of HDAC6 (IC50=36 nM). MPI_5a weakly inhibits other HDAC isoforms and it also inhibits acyl-tubulin accumulation i...
T37427 (2R/S)-6-PNG 68682-01-9 98%
(2R/S)-6-PNG (6-Prenylnaringenin) is a novel natural histone deacetylase inhibitor with anticancer and antitumor activity, and blocks T-type calcium channels to ...
T14947 CHDI-390576 1629729-98-1 98%
CHDI-390576 is a CNS-permeable, selective and potent dibenzoyl isohydroxamic acid class IIa histone deacetylase (HDAC) inhibitor that inhibits class IIa HDAC 4, ...
T83639 YPX-C-05 2894823-79-9 98%
YPX-C-05 is an isohydroxamic acid derivative, an HDAC inhibitor with vasodilatory and antihypertensive activity.YPX-C-05 can be used for the study of hypertensio...
T1857 TMP269 1314890-29-3
TMP269 is an effective, specific class IIa HDAC inhibitor for HDAC4 (IC50: 157 nM), HDAC5 (IC50: 97 nM), HDAC7 (IC50: 43 nM), and HDAC9 (IC50: 23 nM), respective...
T9041 AES-350 847249-57-4
AES-350 is a potent and orally active HDAC6 inhibitor(IC50 and a Ki of 0.0244 μM and 0.035 μM, respectively). It is also against HDAC-3, -8, and -11 in an enzyma...
T2294 BG45 926259-99-6
BG45 is an HDAC I type inhibitor with IC50 of 289 nM, 2.0 μM, 2.2 μM and >20 μM for HDAC3/1/2/6 in cell-free assays, respectively.
T6055 Quisinostat 875320-29-9
Quisinostat (JNJ-26481585) (JNJ-26481585) is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM, modest potent to HDACs...
T16545 Pivanex 122110-53-6
Pivanex (Pivalyloxymethyl butyrate) is an orally active HDAC inhibitor and an antimetastatic and antiangiogenic agent. Pivanex downregulates the Bcr-Abl protein ...
T21505 Suberoyl bis-hydroxamic acid 38937-66-5
Suberoyl bis-hydroxamic acid (SBHA) is a Histone deacetylase (HDAC) inhibitor. HDAC is required for transcriptional modulation, cell cycle regulation and develop...
T6S0033 Crotonoside 1818-71-9
1. Crotonoside (Isoguanosine) has much more active than adenosine in reducing the blood pressure in rabbits and cats, in decreasing the tone of isolated intestin...
T21551 2-hexyl-4-Pentynoic Acid 96017-59-3
2-hexyl-4-Pentynoic Acid, a valproic acid (VPA) derivatives, is a potent and robust HDACs inhibitor with IC50 value of 13 μM.
T2023 MC1568 852475-26-4
MC1568 is a specific HDAC inhibitor for maize HD1-A (IC50: 100 nM, in a cell-free assay). It is 34-fold more selective for HD1-A than HD1-B.
T3193 Pimelic diphenylamide 106 937039-45-7
Pimelic diphenylamide 106 (RGFA-8) is a slow, tight-binding inhibitor of class I HDAC (with IC50 values of 150 nM , 760 nM and 370 nM for HDAC 1, 2, and 3, respe...
Nexturastat A
T1819
Nexturastat A is an effective and specific HDAC6 inhibitor (IC50: 5 nM). Its selectivity is >190-fold than other HDACs.
Elevenostat
T9745
Elevenostat is an HDAC11-selective inhibitor with an IC50 value of 0.235 µM.
NKL 22
T3206
NKL 22 (Histone Deacetylase Inhibitor IV) is an effective Histone Deacetylase Inhibitor.
ACY-775
TQ0074
ACY-775 is an effective and specific inhibitor of HDAC6 (IC50: 7.5 nM).
BML-210
T3204
BML-210 (CAY10433) is a new-type HDAC inhibitor.
MPT0B390
T9963
MPT0B390 is an inhibitor of HDAC and a TIMP3 inducer inhibiting tumor growth, metastasis, and angiogenesis.
MPI_5a
T16129
MPI_5a is an effective and selective inhibitor of HDAC6 (IC50=36 nM). MPI_5a weakly inhibits other HDAC isoforms and it also inhibits acyl-tubulin accumulation i...
(2R/S)-6-PNG
T37427
(2R/S)-6-PNG (6-Prenylnaringenin) is a novel natural histone deacetylase inhibitor with anticancer and antitumor activity, and blocks T-type calcium channels to ...
CHDI-390576
T14947
CHDI-390576 is a CNS-permeable, selective and potent dibenzoyl isohydroxamic acid class IIa histone deacetylase (HDAC) inhibitor that inhibits class IIa HDAC 4, ...
YPX-C-05
T83639
YPX-C-05 is an isohydroxamic acid derivative, an HDAC inhibitor with vasodilatory and antihypertensive activity.YPX-C-05 can be used for the study of hypertensio...
TMP269
T1857
TMP269 is an effective, specific class IIa HDAC inhibitor for HDAC4 (IC50: 157 nM), HDAC5 (IC50: 97 nM), HDAC7 (IC50: 43 nM), and HDAC9 (IC50: 23 nM), respective...
AES-350
T9041
AES-350 is a potent and orally active HDAC6 inhibitor(IC50 and a Ki of 0.0244 μM and 0.035 μM, respectively). It is also against HDAC-3, -8, and -11 in an enzyma...
BG45
T2294
BG45 is an HDAC I type inhibitor with IC50 of 289 nM, 2.0 μM, 2.2 μM and >20 μM for HDAC3/1/2/6 in cell-free assays, respectively.
Quisinostat
T6055
Quisinostat (JNJ-26481585) (JNJ-26481585) is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM, modest potent to HDACs...
Pivanex
T16545
Pivanex (Pivalyloxymethyl butyrate) is an orally active HDAC inhibitor and an antimetastatic and antiangiogenic agent. Pivanex downregulates the Bcr-Abl protein ...
Suberoyl bis-hydroxamic acid
T21505
Suberoyl bis-hydroxamic acid (SBHA) is a Histone deacetylase (HDAC) inhibitor. HDAC is required for transcriptional modulation, cell cycle regulation and develop...
Crotonoside
T6S0033
1. Crotonoside (Isoguanosine) has much more active than adenosine in reducing the blood pressure in rabbits and cats, in decreasing the tone of isolated intestin...
2-hexyl-4-Pentynoic Acid
T21551
2-hexyl-4-Pentynoic Acid, a valproic acid (VPA) derivatives, is a potent and robust HDACs inhibitor with IC50 value of 13 μM.
MC1568
T2023
MC1568 is a specific HDAC inhibitor for maize HD1-A (IC50: 100 nM, in a cell-free assay). It is 34-fold more selective for HD1-A than HD1-B.
Pimelic diphenylamide 106
T3193
Pimelic diphenylamide 106 (RGFA-8) is a slow, tight-binding inhibitor of class I HDAC (with IC50 values of 150 nM , 760 nM and 370 nM for HDAC 1, 2, and 3, respe...
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