HDAC

Histone deacetylases (HDAC) are a class of enzymes that remove acetyl groups (O=C-CH3) from an ε-N-acetyl lysine amino acid on a histone, allowing the histones to wrap the DNA more tightly. This is important because DNA is wrapped around histones, and DNA expression is regulated by acetylation and de-acetylation. Its action is opposite to that of histone acetyltransferase. HDAC proteins are now also called lysine deacetylases (KDAC), to describe their function rather than their target, which also includes non-histone proteins.

Cat. No.	製品名	CAS No.	Purity
T2454	Dacinostat	404951-53-7	98%
T2454	LAQ824 (Dacinostat) is a novel HDAC inhibitor with IC50 of 32 nM and is an activator of the p21 promoter.
T9041	AES-350	847249-57-4	98%
T9041	AES-350 is a potent and orally active HDAC6 inhibitor(IC50 and a Ki of 0.0244 μM and 0.035 μM, respectively). It is also against HDAC-3, -8, and -11 in an enzyma...
T1819	Nexturastat A	1403783-31-2	98%
T1819	Nexturastat A is an effective and specific HDAC6 inhibitor (IC50: 5 nM). Its selectivity is >190-fold than other HDACs.
T6362	Domatinostat	910462-43-0	98%
T6362	4SC-202 is a selective class I HDAC inhibitor with IC50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. Also displays inhibitory acti...
T2294	BG45	926259-99-6	98%
T2294	BG45 is an HDAC I type inhibitor with IC50 of 289 nM, 2.0 μM, 2.2 μM and >20 μM for HDAC3/1/2/6 in cell-free assays, respectively.
T7082	HDAC8-IN-1	1417997-93-3	98%
T7082	MDK-7933 (HDAC8-IN-1) is a HDAC8 inhibitor with an IC50 of 27.2 nM in cancer cell lines. MDK-7933 shows antiproliferative effects toward several human lung cance...
T13996	1-Naphthohydroxamic acid	6953-61-3	98%
T13996	1-Naphthohydroxamic acid (Compound 2) is a potent and selective HDAC8 inhibitor with an IC50 of 14 μM, and it is more selectively for HDAC8 than class I HDAC1 an...
T6474	Divalproex Sodium	76584-70-8	98%
T6474	Divalproex Sodium binds to and inhibits gamma-aminobutyric acid (GABA) transaminase and its anticonvulsant activity may be exerted by increasing brain concentrat...
T17028	Tefinostat	914382-60-8	98%
T17028	Tefinostat (CHR-2845) is a potent monocyte/macrophage-targeted histone deacetylase (HDAC) inhibitor. Tefinostat is cleaved to the active acid CHR-2847 by the int...
T9745	Elevenostat	1454902-97-6	98%
T9745	Elevenostat is an HDAC11-selective inhibitor with an IC50 value of 0.235 µM.
T10777	CG347B	1598426-03-9	98%
T10777	CG347B is a selective inhibitor of HDAC6.
T3206	NKL 22	537034-15-4	98%
T3206	An effective Histone Deacetylase Inhibitor.
T4481	Tucidinostat	1616493-44-7	98%
T4481	Tucidinostat is an effective and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor, with IC50s of 95, 160, 67 and 78 nM, less...
T16545	Pivanex	122110-53-6	98%
T16545	Pivanex is a derivative of Butyric acid and is an orally active HDAC inhibitor. Pivanex has antimetastic and antiangiogenic properties. Pivanex down-regulates bc...
T1083L	Theophylline monohydrate	5967-84-0	98%
T1083L	Theophylline appears to inhibit phosphodiesterase and prostaglandin production, regulate calcium flux and intracellular calcium distribution, and antagonize aden...
T3204	BML-210	537034-17-6	98%
T3204	BML-210 is a new-type HDAC inhibitor.
T6S0033	Crotonoside	1818-71-9	98%
T6S0033	1. Crotonoside has much more active than adenosine in reducing the blood pressure in rabbits and cats, in decreasing the tone of isolated intestinal strips of th...
T21551	2-hexyl-4-Pentynoic Acid	96017-59-3	98%
T21551	2-hexyl-4-Pentynoic Acid, a valproic acid (VPA) derivatives, is a potent and robust HDACs inhibitor with IC50 value of 13 μM.
T6279L	Givinostat hydrochloride	199657-29-9	98%
T6279L	Givinostat hydrochloride is an inhibitor of HDAC with IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Givinostat hydrochloride exhibits anti-inflammato...
T9963	MPT0B390	1817802-18-8	98%
T9963	MPT0B390 is an inhibitor of HDAC and a TIMP3 inducer inhibiting tumor growth, metastasis, and angiogenesis.