Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SKLB-23bb is an orally bioavailable HDAC6-selective inhibitor and also has microtubule-disrupting ability.
説明 | SKLB-23bb is an orally bioavailable HDAC6-selective inhibitor and also has microtubule-disrupting ability. |
ターゲット&IC50 | HDAC6:17 nM |
In vivo | In vivo efficacy evaluations of colorectal HCT116, acute myelocytic leukemia MV4-11, and B cell lymphoma Romas xenografts, SKLB-23bb more effectively inhibited the tumor growth than SAHA even at a 4-fold reduced dose or ACY-1215 at the same dose. SKLB-23bb is a potent oral anticancer candidate for selective HDAC6 inhibitor. |
分子量 | 396.44 |
分子式 | C21H24N4O4 |
CAS No. | 1815580-06-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 32 mg/mL (80.72 mM)
You can also refer to dose conversion for different animals. 詳細
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SKLB-23bb 1815580-06-3 Chromatin/Epigenetic DNA Damage/DNA Repair HDAC SKLB 23bb Histone deacetylases Inhibitor inhibit SKLB23bb inhibitor