Kinesin

A kinesin is a protein belonging to a class of motor proteins found in eukaryotic cells. Kinesins move along microtubule (MT) filaments, and are powered by the hydrolysis of adenosine triphosphate (ATP) (thus kinesins are ATPases). The active movement of kinesins supports several cellular functions including mitosis, meiosis and transport of cellular cargo, such as in axonal transport.

Cat. No.	製品名	CAS No.	Purity
T6393	ARQ 621	1095253-39-6	98%
T6393	ARQ 621 is an allosteric, and selective Eg5 mitotic motor protein inhibitor. Phase 1.
T8487	Empesertib	1443763-60-7	98%
T8487	Empesertib is an orally bioavailable and selective inhibitor Mps1(IC50 < 1 nM), with potential antineoplastic activity.
T77586	Eg5-IN-1		98%
T77586	Eg5-IN-1 is a potent inhibitor of the kinesin family of motor proteins (Eg5) with an IC50 value of 1.97 µM for Eg5.Eg5-IN-1 can be used in cancer research.
T3118	Dimethylenastron	863774-58-7	98%
T3118	Dimethylenastron, an Eg5 inhibitor, arrests cells with monopolar spindles to which all chromosomes attach in a syntelic manner.
T3434	BAY1217389	1554458-53-5	98%
T3434	BAY 1217389 is an effective and selective inhibitor of the monopolar spindle 1 (MPS1) kinase (IC50<10 nM).
T22289	CFI-402257	1610759-22-2	98%
T22289	CFI-402257 is a selective inhibitor of Mps1/TTK kinase (Mps1 Ki = 0.09 nM; EC50 = 6.5 nM)and can be used in studies about hepatocellular carcinoma diseases.
T36816	S-trityl-L-Cysteine	2799-07-7	98%
T36816	S-trityl-L-Cysteine is a non-natural amino acid and an inhibitor of Eg5, also known as KSP and Kif11, a mitotic kinesin necessary for mitotic spindle formation. ...
T8342	BRD9876	32703-82-5	98%
T8342	BRD9876 is a selective inhibitor of MM1S growth.
T11155	Eg5 Inhibitor V, trans-24	869304-55-2	98%
T11155	Eg5 Inhibitor V, trans-24 is a specific and potent Eg5 inhibitor that can be used in cancer research with an IC50 value of 0.65 uM.
T2255	SB-743921 hydrochloride	940929-33-9	98%
T2255	SB-743921 is an effective inhibitor of kinesin spindle protein, KSP, (Ki =0.1 nM).
T2689	AZ3146	1124329-14-1	98%
T2689	AZ3146 is a selective Mps1 inhibitor with IC50 of ~35 nM.
T1839	Mps1-IN-2	1228817-38-6	98%
T1839	Mps1-IN-2 is a potent, selective and ATP-competitive dual Mps1/Plk1 inhibitor.
T12237	NMS-P715	1202055-32-0	98%
T12237	NMS-P715 is a selective and ATP-competitive MPS1 inhibitor(IC50 of 182 nM).
T6209	CW-069	1594094-64-0	98%
T6209	CW069( IC50=75 μM）, an allosteric selective inhibitor of microtubule motor protein HSET, exhibits remarkable specificity over KSP.
T4048	Monastrol	329689-23-8	98%
T4048	Monastrol is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5.
T2313	MPI-0479605	1246529-32-7	98%
T2313	MPI-0479605 is an ATP competitive and selective inhibitor.
T3120	K858 (Racemic)	72926-24-0	98%
T3120	K858 is a selective mitotic kinesin Eg5 inhibitor which acts in an ATP-noncompetitive manner.
T2103	Ispinesib	336113-53-2	98%
T2103	Ispinesib, a selective, effectvie and reversible inhibitor of kinesin spindle protein (KSP), is derived from quinazolinone, with antineoplastic properties.
T12359	Paprotrain	57046-73-8	98%
T12359	Paprotrain is a cell-permeable the kinesin MKLP-2 inhibitor(inhibits the ATPase activity of MKLP-2 with an IC50 of 1.35 μM and a Ki of 3.36 μM )
T2039	GSK-923295	1088965-37-0	98%
T2039	GSK923295 is a selective allosteric inhibitor of CENP-E kinesin motor ATPase(Ki=3.2 nM).