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LRRK2

Leucine-rich repeat kinase 2 (LRRK2), also known as dardarin (from the Basque word "dardara" which means trembling) and PARK8 (from early identified association with Parkinson's disease), is a kinase enzyme that in humans is encoded by the LRRK2 gene. LRRK2 is a member of the leucine-rich repeat kinase family. Variants of this gene are associated with an increased risk of Parkinson's disease and also Crohn's disease.
Cat. No. 製品名 CAS No. Purity Chemical Structure
T6057 URMC-099 1229582-33-5 98%
URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM)...
T39972 EB-42486 2390475-81-5 98%
EB-42486 is an effective and highly selective inhibitor of G2019S-LRRK2 with an IC50 < 0.2 nM.
T5428 BIX 02565 1311367-27-7 98%
BIX 02565 is a potent inhibitor of ribosomal S6 kinase 2 (RSK2, IC50: 1.1 nM).
T7196 HG-10-102-01 1351758-81-0 98%
HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2, IC50 of 20.3 nM).
T7155 JH-II-127 1700693-08-8 98%
JH-II-127 is an orally inhibitor of leucine-rich repeat kinase 2 (LRRK2). It inhibits WT LRRK2, G2019S LRRK2 and A2016T LRRK2 (IC50s = 6.6, 2.2, and 47.7 nM, re...
T1770 GNE-9605 1536200-31-3 98%
GNE-9605 is a highly effective, specifical, and brain-penetrant LRRK2 inhibitor (IC50: 19 nM).
T2014 CCG-1423 285986-88-1 98%
CCG-1423, a selective RhoA pathway inhibitor, suppresses SRF-mediated transcription.
T7729 PF-06454589 1527473-30-8 96.29%
PF-06454589 is a potent inhibitor of LRRK2.
T1945 GNE-7915 1351761-44-8 98%
GNE-7915 is a highly potent, selective and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) inhibitor.
T3053 CZC-25146 1191911-26-8 98.2%
CZC-25146 (CHEMBL2397014) is an effective, specific and metabolically stable LRRK2 inhibitor with IC50 of 4.76/6.87 nM for wild-type LRRK2(Leucine-rich repeat ki...
T39202 CZC-54252 hydrochloride 1784253-05-9 98.21%
CZC-54252 hydrochloride is a selective inhibitor of LRRK2 with IC50s of 1.85 nM and 1.28 nM for wild-type and G2019S LRRK2. CZC-54252 hydrochloride has a neuropr...
T2246 LRRK2-IN-1 1234480-84-2 98.44%
LRRK2-IN-1 is an effective and selective LRRK2 inhibitor.
T5139 CZC-25146 hydrochloride 1330003-04-7 99.06%
CZC-25146 is a selective LRRK2 inhibitor with IC50 of 4.76 nM/6.87 nM for wild type LRRK2 and G2019S LRRK2, respectively.
T16115 MLi-2 1627091-47-7 99.33%
MLi-2 is a structurally novel, highly potent, and selective LRRK2 kinase inhibitor with central nervous system activity. MLi-2 exhibits exceptional potency in a ...
T2022 CZC-54252 1191911-27-9 99.39%
CZC-54252 is a potent inhibitor of LRRK2.
T6176 IKK 16 873225-46-8 99.61%
IKK 16 (IKK Inhibitor VII) is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively.
T2050 PF-06447475 1527473-33-1 99.62%
PF-06447475 is a highly effective, specific, brain penetrant LRRK2 inhibitor with IC0 of 3/11 nM for wild type LRRK2 and G2019S LRRK2 respectively.
T11878 LRRK2 inhibitor 1 1802525-61-6 99.73%
LRRK2 inhibitor 1 is a selective and potent LRRK2 inhibitor with an IC50 of 13 nM.LRRK2 inhibitor 1 inhibits DCLK1 kinase with an IC50 value of 2.61 nM.
T16512 PFE-360 1527475-61-1 99.73%
PFE-360 (PF-06685360) is a potent and selective inhibitor of LRRK2 kinase (IC50: 2.3 nM in vivo).
T2240 GSK2578215A 1285515-21-0 99.81%
GSK2578215A is a potent and selective LRRK2 kinase inhibitor.
URMC-099
T6057
URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM)...
EB-42486
T39972
EB-42486 is an effective and highly selective inhibitor of G2019S-LRRK2 with an IC50 < 0.2 nM.
BIX 02565
T5428
BIX 02565 is a potent inhibitor of ribosomal S6 kinase 2 (RSK2, IC50: 1.1 nM).
HG-10-102-01
T7196
HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2, IC50 of 20.3 nM).
JH-II-127
T7155
JH-II-127 is an orally inhibitor of leucine-rich repeat kinase 2 (LRRK2). It inhibits WT LRRK2, G2019S LRRK2 and A2016T LRRK2 (IC50s = 6.6, 2.2, and 47.7 nM, re...
GNE-9605
T1770
GNE-9605 is a highly effective, specifical, and brain-penetrant LRRK2 inhibitor (IC50: 19 nM).
CCG-1423
T2014
CCG-1423, a selective RhoA pathway inhibitor, suppresses SRF-mediated transcription.
PF-06454589
T7729
PF-06454589 is a potent inhibitor of LRRK2.
GNE-7915
T1945
GNE-7915 is a highly potent, selective and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) inhibitor.
CZC-25146
T3053
CZC-25146 (CHEMBL2397014) is an effective, specific and metabolically stable LRRK2 inhibitor with IC50 of 4.76/6.87 nM for wild-type LRRK2(Leucine-rich repeat ki...
CZC-54252 hydrochloride
T39202
CZC-54252 hydrochloride is a selective inhibitor of LRRK2 with IC50s of 1.85 nM and 1.28 nM for wild-type and G2019S LRRK2. CZC-54252 hydrochloride has a neuropr...
LRRK2-IN-1
T2246
LRRK2-IN-1 is an effective and selective LRRK2 inhibitor.
CZC-25146 hydrochloride
T5139
CZC-25146 is a selective LRRK2 inhibitor with IC50 of 4.76 nM/6.87 nM for wild type LRRK2 and G2019S LRRK2, respectively.
MLi-2
T16115
MLi-2 is a structurally novel, highly potent, and selective LRRK2 kinase inhibitor with central nervous system activity. MLi-2 exhibits exceptional potency in a ...
CZC-54252
T2022
CZC-54252 is a potent inhibitor of LRRK2.
IKK 16
T6176
IKK 16 (IKK Inhibitor VII) is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively.
PF-06447475
T2050
PF-06447475 is a highly effective, specific, brain penetrant LRRK2 inhibitor with IC0 of 3/11 nM for wild type LRRK2 and G2019S LRRK2 respectively.
LRRK2 inhibitor 1
T11878
LRRK2 inhibitor 1 is a selective and potent LRRK2 inhibitor with an IC50 of 13 nM.LRRK2 inhibitor 1 inhibits DCLK1 kinase with an IC50 value of 2.61 nM.
PFE-360
T16512
PFE-360 (PF-06685360) is a potent and selective inhibitor of LRRK2 kinase (IC50: 2.3 nM in vivo).
GSK2578215A
T2240
GSK2578215A is a potent and selective LRRK2 kinase inhibitor.
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