Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Kukoamine A possesses anticancer, cytoprotective, antioxidant, and anti-inflammatory activities, and inhibits trypanothione reductase as a mixed inhibitor (Ki = 1.8 microM).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 28,500 | |||
5 mg | 在庫あり | ¥ 86,000 | |||
10 mg | 在庫あり | ¥ 128,000 | |||
25 mg | 在庫あり | ¥ 202,500 | |||
50 mg | 在庫あり | お問い合わせ | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 95,000 |
説明 | Kukoamine A possesses anticancer, cytoprotective, antioxidant, and anti-inflammatory activities, and inhibits trypanothione reductase as a mixed inhibitor (Ki = 1.8 microM). |
ターゲット&IC50 | LOX:9.5 microM, Trypanothione reductase:1.8 microM(Ki) |
In vitro | The four possible regioisomers of Kukoamine A, as well as a series of Kukoamine A analogs incorporating changes in either the SPM or the DHCA structural units, were evaluated for their antioxidant activity and their inhibitory activity on soybean lipoxygenase (LOX) and lipid peroxidation[1]. The reducing properties of the compounds were evaluated using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging assay and found to be in the range 5-97.5%. Kukoamine A significantly inhibits LOX with IC50 9.5 microM. All tested analogs inhibited lipid peroxidation in the range of 11-100%[1]. |
In vivo | Kukoamine A has neuroprotective effects through inhibiting oxidative stress and apoptosis after whole-brain irradiation (WBI) in rats[1]. |
植物由来 |
分子量 | 530.66 |
分子式 | C28H42N4O6 |
CAS No. | 75288-96-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/mL (113.07 mM)
H2O: 100 mg/mL (188.44 mM)
You can also refer to dose conversion for different animals. 詳細
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Kukoamine A 75288-96-9 Cell Cycle/Checkpoint DNA Damage/DNA Repair Metabolism Microbiology/Virology NF-Κb NF-κB Parasite Lipoxygenase DNA/RNA Synthesis inhibit Inhibitor inhibitor