Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DS-7423 is a small-molecule dual inhibitor of phosphatidylinositol-3-kinase (PI3K) and mammalian target of rapamycin (mTOR). Although DS-7423 potently inhibits PI3Kα (IC50 = 15.6 nM) and mTOR (IC50 = 34.9 nM), it also inhibits other isoforms of class I PI3K (IC50 values: PI3Kβ = 1,143 nM; PI3Kγ = 249 nM; PI3Kδ = 262 nM).
説明 | DS-7423 is a small-molecule dual inhibitor of phosphatidylinositol-3-kinase (PI3K) and mammalian target of rapamycin (mTOR). Although DS-7423 potently inhibits PI3Kα (IC50 = 15.6 nM) and mTOR (IC50 = 34.9 nM), it also inhibits other isoforms of class I PI3K (IC50 values: PI3Kβ = 1,143 nM; PI3Kγ = 249 nM; PI3Kδ = 262 nM). |
ターゲット&IC50 | PI3Kγ:249 nM, PI3Kα:15.6 nM, PI3Kβ:1143 nM, PI3Kδ:262 nM, mTOR:34.9 nM |
In vitro | DS-7423 elevates TP53 expression, enhances p-TP53 on Ser-46 phosphorylation, and stimulates apoptosis-related TP53 target genes (TP53AIP1 and PUMA) in OCCC cells[1]. Additionally, it selectively inhibits class I PI3K isoforms with varying IC50 values: PI3Kβ at 1,143 nM, PI3Kγ at 249 nM, and PI3Kδ at 262 nM[2]. |
分子量 | 520.51 |
分子式 | C22H27F3N10O2 |
CAS No. | 1222104-37-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 65 mg/mL (124.88 mM)
You can also refer to dose conversion for different animals. 詳細
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DS-7423 1222104-37-1 PI3K/Akt/mTOR signaling mTOR PI3K Phosphoinositide 3-kinase Inhibitor DS7423 inhibit PUMA TP53 Mammalian target of Rapamycin OCCC TP53AIP1 DS 7423 inhibitor