Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Mifobate (SR-202) is a potent and specific antagonist of PPARγ. Mifobate shows antiobesity, antidiabetic and antiatherosclerotic effects[1].
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 22,500 | |||
5 mg | 在庫あり | ¥ 66,000 | |||
10 mg | 在庫あり | ¥ 98,500 | |||
25 mg | 在庫あり | ¥ 157,500 | |||
50 mg | 在庫あり | ¥ 222,500 | |||
100 mg | 在庫あり | ¥ 294,000 |
説明 | Mifobate (SR-202) is a potent and specific antagonist of PPARγ. Mifobate shows antiobesity, antidiabetic and antiatherosclerotic effects[1]. |
ターゲット&IC50 | PPARγ:140 μM (IC50) |
In vitro | SR-202 is a new synthetic PPARgamma antagonist,, which inhibits both TZD-stimulated recruitment of the coactivator steroid receptor coactivator-1 and TZD-induced transcriptional activity of the receptor.?In cell culture, SR-202 efficiently antagonizes hormone- and TZD-induced adipocyte differentiation[1]. |
In vivo | In vivo, decreasing PPARgamma activity, either by treatment with SR-202 or by invalidation of one allele of the PPARgamma gene, leads to a reduction of both high fat diet-induced adipocyte hypertrophy and insulin resistance.?These effects are accompanied by a smaller size of the adipocytes and a reduction of TNFalpha and leptin secretion.?Treatment with SR-202 also dramatically improves insulin sensitivity in the diabetic ob/ob mice[1]. |
別名 | SR-202 |
分子量 | 358.65 |
分子式 | C11H17ClO7P2 |
CAS No. | 76541-72-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 35.87 mg/mL (100.01 mM), Sonication and heating are recommended.
You can also refer to dose conversion for different animals. 詳細
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Mifobate 76541-72-5 DNA Damage/DNA Repair Metabolism PPAR diabetes Peroxisome proliferator-activated receptors adipocyte stimulation antiobesity transcriptional SR 202 type 2 obesity differentiation SR-202 SR202 activity selective antidiabetic inhibit Inhibitor inhibitor