Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CUDA is an effective soluble cyclohydrolase inhibitor with IC50 of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively. CUDA selectively increases the activity of peroxisome proliferator-activated receptor (PPAR) alpha. CUDA may be valuable for the study of cardiovascular diseases.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
5 mg | 在庫あり | ¥ 9,500 | |||
10 mg | 在庫あり | ¥ 15,500 | |||
25 mg | 在庫あり | ¥ 30,500 | |||
50 mg | 在庫あり | ¥ 50,500 | |||
100 mg | 在庫あり | ¥ 81,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 10,500 |
説明 | CUDA is an effective soluble cyclohydrolase inhibitor with IC50 of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively. CUDA selectively increases the activity of peroxisome proliferator-activated receptor (PPAR) alpha. CUDA may be valuable for the study of cardiovascular diseases. |
ターゲット&IC50 | sEH (human):112 nM, sEH (mouse):11.1 nM |
In vitro | CUDA (10 μM; 18 hours) produced a 6-fold and 3-fold increase of PPARalpha in COS-7 cells. CUDA does not change the expression of PPARalpha protein. It competitively inhibits the binding of Wy-14643 (pirinixic acid) to the ligand binding domain of PPARalpha, indicating that it acts as a PPARalpha ligand. |
分子量 | 340.5 |
分子式 | C19H36N2O3 |
CAS No. | 479413-68-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (73.42 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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CUDA 479413-68-8 Metabolism DNA Damage/DNA Repair PPAR Epoxide Hydrolase PPARalpha epoxide Peroxisome proliferator-activated receptors cardiovascular Inhibitor peroxisome Soluble inhibit disease receptor sEH proliferator-activated hypotensive PPARα hydrolase lipid-lowering inhibitor