Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tolimidone (NSC 314335) is a chemical compound which inhibits acid secretion in animal models and also acts as a bronchodilator in histamine-challenged animals.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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5 mg | 在庫あり | ¥ 10,000 | |||
10 mg | 在庫あり | ¥ 16,000 | |||
25 mg | 在庫あり | ¥ 27,500 | |||
50 mg | 在庫あり | ¥ 44,000 | |||
100 mg | 在庫あり | ¥ 65,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 11,000 |
説明 | Tolimidone (NSC 314335) is a chemical compound which inhibits acid secretion in animal models and also acts as a bronchodilator in histamine-challenged animals. |
ターゲット&IC50 | Lyn:63 nM(EC50) |
In vitro | In an in vitro broad kinase screen MLR-1023 activated the nonreceptor-linked Src-related tyrosine kinase Lyn. MLR-1023 increased the Vmax of Lyn with an EC50 of 63 nM. This Lyn kinase activation was ATP binding site independent, indicating that MLR-1023 regulated the kinase through an allosteric mechanism[1]. |
In vivo | MLR-1023-mediated blood glucose lowering depends on Lyn kinase activity[1]. MLR-1023 is an insulin receptor-potentiating agent that produces a rapid-onset and durable blood glucose-lowering activity in diabetic animals[2]. |
細胞研究 | Adipocyte differentiation is assessed in mouse 3T3-L1 cells after 8 days of incubation with MLR-1023 or rosiglitazone (10 μM).(Only for Reference) |
別名 | NSC 314335, MLR-1023, CP-26154 |
分子量 | 202.21 |
分子式 | C11H10N2O2 |
CAS No. | 41964-07-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 20.2 mg/mL (100 mM)
Ethanol: 4 mg/mL (20 mM)
You can also refer to dose conversion for different animals. 詳細
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Tolimidone 41964-07-2 Angiogenesis Tyrosine Kinase/Adaptors Src NSC-314335 NSC 314335 MLR-1023 Inhibitor CP-26154 CP 26154 MLR 1023 NSC314335 inhibit CP26154 MLR1023 inhibitor