iGluR

Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that are activated by the neurotransmitter glutamate.[1] They mediate the majority of excitatory synaptic transmission throughout the central nervous system and are key players in synaptic plasticity, which is important for learning and memory. iGluRs have been divided into four subtypes on the basis of their ligand binding properties (pharmacology) and sequence similarity: AMPA receptors, kainate receptors, NMDA receptors and delta receptors.

Cat. No.	製品名	CAS No.	Purity
T3957	Farampator	211735-76-1	98%
T3957	Farampator (CX-691) (CX-691;Org24448) is a positive modulator of AMPA receptor.
T20571	Cis-PDA	46026-75-9	98%
T20571	cis-PDA (cis PDA) is a general ionotropic receptor antagonist. cis-PDA acts by blocking NMDA, AMPA, and kainate-mediated responses.
T12187L	Naspm trihydrochloride	1049731-36-3	98%
T12187L	Naspm trihydrochloride (1-Naphthylacetyl spermine trihydrochloride) is a synthetic analogue of Joro spider toxin and is an antagonist of calcium permeable AMPA (...
T16451	PEAQX tetrasodium hydrate	T16451	98%
T16451	PEAQX tetrasodium hydrate (PEAQX tetrasodium hydrate (459836-30-7 free base)) is an orally available NMDA antagonist that is potent and selective. The IC50 value...
T12406	PEPA	141286-78-4
T12406	PEPA is an allosteric AMPA receptors modulator; binds to the GluA2o and GluA3o LBDs and can be utilized as an indicator of AMPA receptor heterogeneity.
T22542	1-Aminocyclobutanecarboxylic acid	22264-50-2
T22542	1-Aminocyclobutanecarboxylic acid (ACBC) is a NMDA receptor partial agonist. 1-Aminocyclobutanecarboxylic acid act at the glycine site, NR1[1].
T6871	L-Glutamic acid monosodium salt	142-47-2
T6871	L-Glutamic acid monosodium salt (MSG) (Monosodium glutamate) is an activator of mGlu1 receptor.
T1443	Memantine hydrochloride	41100-52-1
T1443	Memantine hydrochloride (Memantine HCl) is an AMANTADINE derivative that has some dopaminergic effects. Memantine hydrochloride has been proposed as an antiparki...
T0015	Mephenesin	59-47-2
T0015	Mephenesin (Cresoxydiol) is a centrally acting muscle relaxant with a short duration of action.
T1946	Felbamate	25451-15-4
T1946	Felbamate (W-554) is an Anti-epileptic Agent. The physiologic effect of felbamate is by means of Decreased Central Nervous System Disorganized Electrical Activit...
T6259	Dizocilpine	77086-21-6
T6259	MK-801 (Dizocilpine (MK-801)) is a potent N-methyl-D-aspartate (NMDA) receptor antagonist with Ki of 30.5 nM.
TQ0289	LY450108	376594-67-1	100%
TQ0289	LY450108 is a potentiator of the AMPA receptor that can be used in Parkinson's disease studies.
T8459	DNQX disodium salt	1312992-24-7	100%
T8459	DNQX disodium salt is a water-soluble form of selective antagonist of non-NMDA receptor
T8435	YM90K	154164-30-4	100%
T8435	YM90K (6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-) hydrochloride is an antagonist of AMPA receptor.
T10930	D-AP5	79055-68-8	100%
T10930	D-AP5 (D-APV) is a NMDA receptor antagonist.
T7706	LY-404187	211311-95-4	100%
T7706	LY404187 is a positive allosteric modulator of AMPA receptors
T4171	PEAQX	459836-30-7	100%
T4171	PEAQX (NVP-AAM077)(NVP-AAM 077) is an effective and orally available NMDA antagonist. It can inhibit human NMDA receptors for 1A/2A(IC50: 270 nM), rather than 1A...
T16801	(RS)-(Tetrazol-5-yl)glycine	138199-51-6	95.00%
T16801	(RS)-(Tetrazol-5-yl)glycine (LY 285265) (D,L-(tetrazol-5-yl)glycine) is an effective and selective N-methyl-D-aspartate receptor agonist. (RS)-(Tetrazol-5-yl)gly...
T10774	CFM-2	178616-26-7	97.16%
T10774	CFM-2, a potent and selective non-competitive antagonist of AMPAR (AMPAR), exhibits anticonvulsant activity across various seizure models.
T7355	IC87201	866927-10-8	97.44%
T7355	IC87201 is a nNOS-PDZ/PSD-95-PDZ inhibitor. IC87201 showed great promise in cellular experiments and animal models of ischemic stroke and pain.