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iGluR

Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that are activated by the neurotransmitter glutamate.[1] They mediate the majority of excitatory synaptic transmission throughout the central nervous system and are key players in synaptic plasticity, which is important for learning and memory. iGluRs have been divided into four subtypes on the basis of their ligand binding properties (pharmacology) and sequence similarity: AMPA receptors, kainate receptors, NMDA receptors and delta receptors.
Cat. No. 製品名 CAS No. Purity Chemical Structure
T20571 Cis-PDA 46026-75-9 98%
cis-PDA (cis PDA) is a general ionotropic receptor antagonist. cis-PDA acts by blocking NMDA, AMPA, and kainate-mediated responses.
T12187L Naspm trihydrochloride 1049731-36-3 98%
Naspm trihydrochloride (1-Naphthylacetyl spermine trihydrochloride) is a synthetic analogue of Joro spider toxin and is an antagonist of calcium permeable AMPA (...
T16451 PEAQX tetrasodium hydrate 98%
PEAQX tetrasodium hydrate (PEAQX tetrasodium hydrate (459836-30-7 free base)) is an orally available NMDA antagonist that is potent and selective. The IC50 value...
T22542 1-Aminocyclobutanecarboxylic acid 22264-50-2
1-Aminocyclobutanecarboxylic acid (ACBC) is a NMDA receptor partial agonist. 1-Aminocyclobutanecarboxylic acid act at the glycine site, NR1[1].
T6871 L-Glutamic acid monosodium salt 142-47-2
L-Glutamic acid monosodium salt (MSG) (Monosodium glutamate) is an activator of mGlu1 receptor.
T0015 Mephenesin 59-47-2
Mephenesin (Cresoxydiol) is a centrally acting muscle relaxant with a short duration of action.
T1946 Felbamate 25451-15-4
Felbamate (W-554) is an Anti-epileptic Agent. The physiologic effect of felbamate is by means of Decreased Central Nervous System Disorganized Electrical Activit...
T6259 Dizocilpine 77086-21-6
MK-801 (Dizocilpine (MK-801)) is a potent N-methyl-D-aspartate (NMDA) receptor antagonist with Ki of 30.5 nM.
TQ0289 LY450108 376594-67-1 100%
LY450108 is a potentiator of the AMPA receptor that can be used in Parkinson's disease studies.
T8459 DNQX disodium salt 1312992-24-7 100%
DNQX disodium salt is a water-soluble form of selective antagonist of non-NMDA receptor
T8435 YM90K 154164-30-4 100%
YM90K (6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-) hydrochloride is an antagonist of AMPA receptor.
T10930 D-AP5 79055-68-8 100%
D-AP5 (D-APV) is a NMDA receptor antagonist.
T7706 LY-404187 211311-95-4 100%
LY404187 is a positive allosteric modulator of AMPA receptors
T4171 PEAQX 459836-30-7 100%
PEAQX (NVP-AAM077)(NVP-AAM 077) is an effective and orally available NMDA antagonist. It can inhibit human NMDA receptors for 1A/2A(IC50: 270 nM), rather than 1A...
T16801 (RS)-(Tetrazol-5-yl)glycine 138199-51-6 95.00%
(RS)-(Tetrazol-5-yl)glycine (LY 285265) (D,L-(tetrazol-5-yl)glycine) is an effective and selective N-methyl-D-aspartate receptor agonist. (RS)-(Tetrazol-5-yl)gly...
T12406 PEPA 141286-78-4 95.39%
PEPA is an allosteric AMPA receptors modulator; binds to the GluA2o and GluA3o LBDs and can be utilized as an indicator of AMPA receptor heterogeneity.
T10774 CFM-2 178616-26-7 97.16%
CFM-2, a potent and selective non-competitive antagonist of AMPAR (AMPAR), exhibits anticonvulsant activity across various seizure models.
T7355 IC87201 866927-10-8 97.44%
IC87201 is a nNOS-PDZ/PSD-95-PDZ inhibitor. IC87201 showed great promise in cellular experiments and animal models of ischemic stroke and pain.
T15820 Mibampator 375345-95-2 97.63%
Mibampator (LY451395) is an effective and selective AMPA receptor potentiator.
T7108 Omberacetam 157115-85-0 98%
Omberacetam (Noopept) is a synthetic dipeptide that has been shown to produce positive nootropic and cognitive effects in animal models by a mechanism similar to...
cis-PDA
T20571
cis-PDA (cis PDA) is a general ionotropic receptor antagonist. cis-PDA acts by blocking NMDA, AMPA, and kainate-mediated responses.
Naspm trihydrochloride
T12187L
Naspm trihydrochloride (1-Naphthylacetyl spermine trihydrochloride) is a synthetic analogue of Joro spider toxin and is an antagonist of calcium permeable AMPA (...
PEAQX tetrasodium hydrate
T16451
PEAQX tetrasodium hydrate (PEAQX tetrasodium hydrate (459836-30-7 free base)) is an orally available NMDA antagonist that is potent and selective. The IC50 value...
1-Aminocyclobutanecarboxylic acid
T22542
1-Aminocyclobutanecarboxylic acid (ACBC) is a NMDA receptor partial agonist. 1-Aminocyclobutanecarboxylic acid act at the glycine site, NR1[1].
L-Glutamic acid monosodium salt
T6871
L-Glutamic acid monosodium salt (MSG) (Monosodium glutamate) is an activator of mGlu1 receptor.
Mephenesin
T0015
Mephenesin (Cresoxydiol) is a centrally acting muscle relaxant with a short duration of action.
Felbamate
T1946
Felbamate (W-554) is an Anti-epileptic Agent. The physiologic effect of felbamate is by means of Decreased Central Nervous System Disorganized Electrical Activit...
Dizocilpine
T6259
MK-801 (Dizocilpine (MK-801)) is a potent N-methyl-D-aspartate (NMDA) receptor antagonist with Ki of 30.5 nM.
LY450108
TQ0289
LY450108 is a potentiator of the AMPA receptor that can be used in Parkinson's disease studies.
DNQX disodium salt
T8459
DNQX disodium salt is a water-soluble form of selective antagonist of non-NMDA receptor
YM90K
T8435
YM90K (6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-) hydrochloride is an antagonist of AMPA receptor.
D-AP5
T10930
D-AP5 (D-APV) is a NMDA receptor antagonist.
LY-404187
T7706
LY404187 is a positive allosteric modulator of AMPA receptors
PEAQX
T4171
PEAQX (NVP-AAM077)(NVP-AAM 077) is an effective and orally available NMDA antagonist. It can inhibit human NMDA receptors for 1A/2A(IC50: 270 nM), rather than 1A...
(RS)-(Tetrazol-5-yl)glycine
T16801
(RS)-(Tetrazol-5-yl)glycine (LY 285265) (D,L-(tetrazol-5-yl)glycine) is an effective and selective N-methyl-D-aspartate receptor agonist. (RS)-(Tetrazol-5-yl)gly...
PEPA
T12406
PEPA is an allosteric AMPA receptors modulator; binds to the GluA2o and GluA3o LBDs and can be utilized as an indicator of AMPA receptor heterogeneity.
CFM-2
T10774
CFM-2, a potent and selective non-competitive antagonist of AMPAR (AMPAR), exhibits anticonvulsant activity across various seizure models.
IC87201
T7355
IC87201 is a nNOS-PDZ/PSD-95-PDZ inhibitor. IC87201 showed great promise in cellular experiments and animal models of ischemic stroke and pain.
Mibampator
T15820
Mibampator (LY451395) is an effective and selective AMPA receptor potentiator.
Omberacetam
T7108
Omberacetam (Noopept) is a synthetic dipeptide that has been shown to produce positive nootropic and cognitive effects in animal models by a mechanism similar to...
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