Powder: -20°C for 3 years | In solvent: -80°C for 1 year
(RS)-(Tetrazol-5-yl)glycine (LY 285265) (D,L-(tetrazol-5-yl)glycine) is an effective and selective N-methyl-D-aspartate receptor agonist. (RS)-(Tetrazol-5-yl)glycine has EC50s of 99 nM, 1.7 μM for GluN1/GluN2D, and GluN1/GluN2A, respectively.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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5 mg | 在庫あり | ¥ 14,000 | |||
10 mg | 在庫あり | ¥ 22,500 | |||
25 mg | 在庫あり | ¥ 55,000 | |||
50 mg | 在庫あり | ¥ 94,500 | |||
100 mg | 在庫あり | ¥ 135,500 |
説明 | (RS)-(Tetrazol-5-yl)glycine (LY 285265) (D,L-(tetrazol-5-yl)glycine) is an effective and selective N-methyl-D-aspartate receptor agonist. (RS)-(Tetrazol-5-yl)glycine has EC50s of 99 nM, 1.7 μM for GluN1/GluN2D, and GluN1/GluN2A, respectively. |
ターゲット&IC50 | GluN1/GluN2D:(EC50)99 nM, GluN1/GluN2A:1.7 μM(EC50) |
In vitro | (RS)-(Tetrazol-5-yl)glycine does not appreciably inhibit the binding of D,L-alpha-[5-methyl-3H] amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA), [3H]kainate, or [3H]glycine (IC50s>30 μM). (RS)-(Tetrazol-5-yl)glycine displaces NMDA receptor binding to rat brain membranes as measured using [3H]CGS19755 (IC50=98 nM) and [3H]glutamate (IC50=36 nM) as ligands [1]. |
In vivo | (RS)-(Tetrazol-5-yl)glycine is a potent convulsant when given to neonatal rats (ED50=0.071 mg/kg; i.p.). (RS)-(Tetrazol-5-yl)glycine (D,L-(tetrazol-5-yl)glycine; 1.25, 1.5 mg/kg; IP) causes seizure responses and Fos in the NR1+/+ and NR1-/- mice [1][3]. |
別名 | LY 285265, D,L-(tetrazol-5-yl)glycine |
分子量 | 143.1 |
分子式 | C3H5N5O2 |
CAS No. | 138199-51-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: < 1.43 mg/mL (10 mM, insoluble or slightly soluble)
You can also refer to dose conversion for different animals. 詳細
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(RS)-(Tetrazol-5-yl)glycine 138199-51-6 Membrane transporter/Ion channel Neuroscience iGluR NMDAR LY285265 Fos GluN2D Ionotropic glutamate receptors inhibit LY-285265 Inhibitor (RS)(Tetrazol5yl)glycine GluN1 (RS) (Tetrazol 5 yl)glycine LY 285265 D,L-(tetrazol-5-yl)glycine GluN2A NMDA seizure inhibitor