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Ligand for E3 Ligase

 A required PROTAC component is a ligand binding to an E3 ubiquitin ligase, which is then joined to another ligand binding to a protein to be degraded via the ubiquitin–proteasome system. The advent of nonpeptidic small-molecule E3 ligase ligands, notably for von Hippel–Lindau (VHL) and cereblon (CRBN), revolutionized the field and ushered in the design of drug-like PROTACs with potent and selective degradation activity.
Cat. No. 製品名 CAS No. Purity Chemical Structure
T17916 Pomalidomide-PEG4-C2-NH2 2225940-52-1 98%
Pomalidomide-PEG4-C2-NH2 (E3 Ligase Ligand-Linker Conjugates 22) is a synthesized E3 ligase ligand-linker conjugate incorporating the Pomalidomide-based cereblon...
T3549 Avadomide 1015474-32-4 98%
Avadomide (CC 122) is an orally available pleiotropic pathway modulator with potential antineoplastic activity.
T40016 Thalidomide-NH-CH2-COOH 927670-97-1 98%
Thalidomide-NH-CH2-COOH ((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycine) is a synthesized E3 ligase ligand-linker conjugate containing a Thalidomi...
T17875 Pomalidomide-C2-NH2 1957235-66-3 98%
Pomalidomide-C2-NH2 (4-[(2-Aminoethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione) is a synthesized E3 ligase ligand-linker conjugate containing a Po...
T9370 DCBP-1 2484739-25-3 98%
dCBP-1 is a chemical degrader of p300/CBP. dCBP-1 hijacks the E3 ubiquitin ligase CRBN for selective degradation of p300/CBP. Degradation of p300/CBP by dCBP-1 l...
T13671 (S,R,S)-AHPC-Me hydrochloride 1948273-03-7 98%
(S,R,S)-AHPC-Me hydrochloride (VHL ligand 2 hydrochloride) is a chemical compound utilized in the synthesis of ARV-771, an exceptionally potent BET protein degra...
T1642 Lenalidomide 191732-72-6 98%
Lenalidomide (CC-5013) is a potent inhibitor of TNF-α that, at 10 μM, alters gene expression and cell viability in a range of cancer cell lines.
T18675 (S,R,S)-AHPC-PEG2-NH2 dihydrochloride 2341796-76-5 98%
(S,R,S)-AHPC-PEG2-NH2 dihydrochloride (VH032-linker 12) is a synthesized E3 ligase ligand-linker conjugate incorporating the (S,R,S)-AHPC based VHL ligand and 2-...
T17881 (S,R,S)-AHPC-C10-NH2 2341796-74-3 98%
(S,R,S)-AHPC-C10-NH2 (VH032-C10-NH2) is a synthesized E3 ligase ligand-linker conjugate incorporating the (S,R,S)-AHPC based VHL ligand and a linker used for BET...
T7753 Thalidomide-O-COOH 1061605-21-7 98%
Thalidomide-O-COOH (Cereblon ligand 3) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. It can be connected to the ligand for pr...
T17920 (S,R,S)-AHPC-PEG1-N3 2101200-09-1 98%
(S,R,S)-AHPC-PEG1-N3 (E3 ligase Ligand-Linker Conjugates 3) is a synthesized E3 ligase ligand-linker conjugate. (S,R,S)-AHPC-PEG1-N3 incorporates the (S,R,S)-AHP...
T7761 Pomalidomide-C2-NH2 hydrochloride 2305369-00-8 98%
Pomalidomide-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate. Pomalidomide-C2-NH2 hydrochloride incorporates the Pomalidomide based cereb...
T18819 Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride 2376990-30-4 98%
Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride incorporates an E3 ligase ligand and a linker. Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride can be used as an immu...
T17879 E3 ligase Ligand 8 1225383-33-4 98%
E3 ligase Ligand 8 is a ligand for E3 ubiquitin ligase. The E3 ligase Ligand 8 can be linked to protein ligands through linkers to form PROTACs, which are induce...
T4207 (S,R,S)-AHPC hydrochloride 1448189-80-7 98%
(S,R,S)-AHPC hydrochloride (Protein degrader 1 hydrochloride) is a building block in the synthesis of proteolysis-targeting chimera technologies (PROTACs).
T40503 Thalidomide-5-methyl 40313-92-6 98%
Thalidomide-5-methyl is the Thalidomide-based cereblon (CRBN) ligand. Thalidomide-5-methyl is used in the recruitment of CRBN protein.
T10359 AR antagonist 1 1818885-54-9
AR antagonist 1 is a potent antagonist of the androgen receptor. It binds to E3 ligase ligands with weak binding affinities to VHL protein in the synthesis of PR...
TQ0121 VH-298 2097381-85-4 100%
VH-298 is a potent inhibitor of VHL that stabilizes HIF-α and elicits a hypoxic response via a different mechanism, that is the blockade of the VHL:HIF-α protein...
T40017 5-Aminothalidomide 191732-76-0 100%
5-Aminothalidomide is a E3 ligase ligand used in PROTAC technology.
T7791 Iberdomide 1323403-33-3 100%
Iberdomide (CC-220) is a modulator of cereblon( IC50 value of 60 nM in a competitive TR-FRET assay).
Pomalidomide-PEG4-C2-NH2
T17916
Pomalidomide-PEG4-C2-NH2 (E3 Ligase Ligand-Linker Conjugates 22) is a synthesized E3 ligase ligand-linker conjugate incorporating the Pomalidomide-based cereblon...
Avadomide
T3549
Avadomide (CC 122) is an orally available pleiotropic pathway modulator with potential antineoplastic activity.
Thalidomide-NH-CH2-COOH
T40016
Thalidomide-NH-CH2-COOH ((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycine) is a synthesized E3 ligase ligand-linker conjugate containing a Thalidomi...
Pomalidomide-C2-NH2
T17875
Pomalidomide-C2-NH2 (4-[(2-Aminoethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione) is a synthesized E3 ligase ligand-linker conjugate containing a Po...
dCBP-1
T9370
dCBP-1 is a chemical degrader of p300/CBP. dCBP-1 hijacks the E3 ubiquitin ligase CRBN for selective degradation of p300/CBP. Degradation of p300/CBP by dCBP-1 l...
(S,R,S)-AHPC-Me hydrochloride
T13671
(S,R,S)-AHPC-Me hydrochloride (VHL ligand 2 hydrochloride) is a chemical compound utilized in the synthesis of ARV-771, an exceptionally potent BET protein degra...
Lenalidomide
T1642
Lenalidomide (CC-5013) is a potent inhibitor of TNF-α that, at 10 μM, alters gene expression and cell viability in a range of cancer cell lines.
(S,R,S)-AHPC-PEG2-NH2 dihydrochloride
T18675
(S,R,S)-AHPC-PEG2-NH2 dihydrochloride (VH032-linker 12) is a synthesized E3 ligase ligand-linker conjugate incorporating the (S,R,S)-AHPC based VHL ligand and 2-...
(S,R,S)-AHPC-C10-NH2
T17881
(S,R,S)-AHPC-C10-NH2 (VH032-C10-NH2) is a synthesized E3 ligase ligand-linker conjugate incorporating the (S,R,S)-AHPC based VHL ligand and a linker used for BET...
Thalidomide-O-COOH
T7753
Thalidomide-O-COOH (Cereblon ligand 3) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. It can be connected to the ligand for pr...
(S,R,S)-AHPC-PEG1-N3
T17920
(S,R,S)-AHPC-PEG1-N3 (E3 ligase Ligand-Linker Conjugates 3) is a synthesized E3 ligase ligand-linker conjugate. (S,R,S)-AHPC-PEG1-N3 incorporates the (S,R,S)-AHP...
Pomalidomide-C2-NH2 hydrochloride
T7761
Pomalidomide-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate. Pomalidomide-C2-NH2 hydrochloride incorporates the Pomalidomide based cereb...
Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride
T18819
Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride incorporates an E3 ligase ligand and a linker. Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride can be used as an immu...
E3 ligase Ligand 8
T17879
E3 ligase Ligand 8 is a ligand for E3 ubiquitin ligase. The E3 ligase Ligand 8 can be linked to protein ligands through linkers to form PROTACs, which are induce...
(S,R,S)-AHPC hydrochloride
T4207
(S,R,S)-AHPC hydrochloride (Protein degrader 1 hydrochloride) is a building block in the synthesis of proteolysis-targeting chimera technologies (PROTACs).
Thalidomide-5-methyl
T40503
Thalidomide-5-methyl is the Thalidomide-based cereblon (CRBN) ligand. Thalidomide-5-methyl is used in the recruitment of CRBN protein.
AR antagonist 1
T10359
AR antagonist 1 is a potent antagonist of the androgen receptor. It binds to E3 ligase ligands with weak binding affinities to VHL protein in the synthesis of PR...
VH-298
TQ0121
VH-298 is a potent inhibitor of VHL that stabilizes HIF-α and elicits a hypoxic response via a different mechanism, that is the blockade of the VHL:HIF-α protein...
5-Aminothalidomide
T40017
5-Aminothalidomide is a E3 ligase ligand used in PROTAC technology.
Iberdomide
T7791
Iberdomide (CC-220) is a modulator of cereblon( IC50 value of 60 nM in a competitive TR-FRET assay).
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