Ligand for E3 Ligase

A required PROTAC component is a ligand binding to an E3 ubiquitin ligase, which is then joined to another ligand binding to a protein to be degraded via the ubiquitin–proteasome system. The advent of nonpeptidic small-molecule E3 ligase ligands, notably for von Hippel–Lindau (VHL) and cereblon (CRBN), revolutionized the field and ushered in the design of drug-like PROTACs with potent and selective degradation activity.

Cat. No.	製品名	CAS No.	Purity
T17916	Pomalidomide-PEG4-C2-NH2	2225940-52-1	98%
T17916	Pomalidomide-PEG4-C2-NH2 (E3 Ligase Ligand-Linker Conjugates 22) is a synthesized E3 ligase ligand-linker conjugate incorporating the Pomalidomide-based cereblon...
T40016	Thalidomide-NH-CH2-COOH	927670-97-1	98%
T40016	Thalidomide-NH-CH2-COOH ((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycine) is a synthesized E3 ligase ligand-linker conjugate containing a Thalidomi...
T17875	Pomalidomide-C2-NH2	1957235-66-3	98%
T17875	Pomalidomide-C2-NH2 (4-[(2-Aminoethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione) is a synthesized E3 ligase ligand-linker conjugate containing a Po...
T9370	DCBP-1	2484739-25-3	98%
T9370	dCBP-1 is a chemical degrader of p300/CBP. dCBP-1 hijacks the E3 ubiquitin ligase CRBN for selective degradation of p300/CBP. Degradation of p300/CBP by dCBP-1 l...
T13671	(S,R,S)-AHPC-Me hydrochloride	1948273-03-7	98%
T13671	(S,R,S)-AHPC-Me hydrochloride (VHL ligand 2 hydrochloride) is a chemical compound utilized in the synthesis of ARV-771, an exceptionally potent BET protein degra...
T18675	(S,R,S)-AHPC-PEG2-NH2 dihydrochloride	2341796-76-5	98%
T18675	(S,R,S)-AHPC-PEG2-NH2 dihydrochloride (VH032-linker 12) is a synthesized E3 ligase ligand-linker conjugate incorporating the (S,R,S)-AHPC based VHL ligand and 2-...
T17881	(S,R,S)-AHPC-C10-NH2	2341796-74-3	98%
T17881	(S,R,S)-AHPC-C10-NH2 (VH032-C10-NH2) is a synthesized E3 ligase ligand-linker conjugate, comprising the (S,R,S)-AHPC-based VHL ligand and a linker, designed for ...
T7753	Thalidomide-O-COOH	1061605-21-7	98%
T7753	Thalidomide-O-COOH (Cereblon ligand 3) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. It can be connected to the ligand for pr...
T17920	(S,R,S)-AHPC-PEG1-N3	2101200-09-1	98%
T17920	(S,R,S)-AHPC-PEG1-N3 (E3 ligase Ligand-Linker Conjugates 3) is a synthesized E3 ligase ligand-linker conjugate. (S,R,S)-AHPC-PEG1-N3 incorporates the (S,R,S)-AHP...
T18819	Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride	2376990-30-4	98%
T18819	Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride incorporates an E3 ligase ligand and a linker. Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride can be used as an immu...
T40503	Thalidomide-5-methyl	40313-92-6	98%
T40503	Thalidomide-5-methyl is the Thalidomide-based cereblon (CRBN) ligand. Thalidomide-5-methyl is used in the recruitment of CRBN protein.
T0213	Thalidomide	50-35-1
T0213	Thalidomide (Thalomid) is a synthetic derivative of glutamic acid (alpha-phthalimido-glutarimide) with teratogenic, immunomodulatory, anti-inflammatory and anti-...
TQ0121	VH-298	2097381-85-4	100%
TQ0121	VH-298 is a potent inhibitor of VHL that stabilizes HIF-α and elicits a hypoxic response via a different mechanism, that is the blockade of the VHL:HIF-α protein...
T40017	5-Aminothalidomide	191732-76-0	100%
T40017	5-Aminothalidomide is a E3 ligase ligand used in PROTAC technology.
T7791	Iberdomide	1323403-33-3	100%
T7791	Iberdomide (CC-220) is a modulator of cereblon( IC50 value of 60 nM in a competitive TR-FRET assay).
T22922	Lenalidomide hemihydrate	847871-99-2	100%
T22922	Lenalidomide hemihydrate is a TNF-α secretion inhibitor (IC50 = 13 nM). Lenalidomide hemihydrate could bound endogenous CRBN and recombinant CRBN-DNA damage bind...
T15190L	(S,R,S)-AHPC-PEG4-NH2	2010159-57-4	94.31%
T15190L	(S,R,S)-AHPC-PEG4-NH2 (VHL Ligand-Linker Conjugates 4) is a synthetic E3 ligase ligand-linker conjugate comprising a VHL ligand based on (S,R,S)-AHPC and a 4-uni...
T18640	(S,R,S)-AHPC-C4-NH2 hydrochloride	2245697-83-8	95.05%
T18640	(S,R,S)-AHPC-C4-NH2 hydrochloride (E3 ligase Ligand-Linker Conjugates 28) is a synthesized E3 ligase ligand-linker conjugate incorporating the (S,R,S)-AHPC based...
T18831	Thalidomide-propargyl	2098487-39-7	95.14%
T18831	Thalidomide-propargyl, a Thalidomide-derived Cereblon ligand, facilitates the recruitment of Cereblon. It can be attached to the protein ligand via a linker, pro...
T17919	Thalidomide-O-amido-C6-NH2 TFA	1950635-14-9	95.16%
T17919	Thalidomide-O-amido-C6-NH2 TFA (Cereblon Ligand-Linker Conjugates 11 TFA), a synthesized E3 ligase ligand-linker conjugate containing a Thalidomide-based cereblo...