Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Thalidomide (Thalomid) is a synthetic derivative of glutamic acid (alpha-phthalimido-glutarimide) with teratogenic, immunomodulatory, anti-inflammatory and anti-angiogenic properties.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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200 mg | 在庫あり | ¥ 11,500 | |||
500 mg | 在庫あり | ¥ 22,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 11,500 |
説明 | Thalidomide (Thalomid) is a synthetic derivative of glutamic acid (alpha-phthalimido-glutarimide) with teratogenic, immunomodulatory, anti-inflammatory and anti-angiogenic properties. |
ターゲット&IC50 | CRL4CRBN:250 nM (Kd) |
In vitro | Thalidomide selectively inhibits the production of tumor necrosis factor-alpha (TNF-α) in human monocytes stimulated by lipopolysaccharides and other agonists. Its suppression of TNF-α is mediated through the enhancement of mRNA degradation. Moreover, thalidomide exerts a direct effect on MM cell lines by inducing apoptosis and G1 phase growth arrest, as well as on patient MM cells resistant to melphalan, doxorubicin hydrochloride, and dexamethasone. |
In vivo | Administering 200mg/kg of Thalidomide resulted in the inhibition of vascularization in the corneal region within rabbits, with the inhibition rate ranging from 30% to 51% across three experiments. |
別名 | Thalomid, Sedoval |
分子量 | 258.23 |
分子式 | C13H10N2O4 |
CAS No. | 50-35-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 6.5 mg/mL (25 mM)
You can also refer to dose conversion for different animals. 詳細
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Thalidomide 50-35-1 Apoptosis Autophagy PROTAC TNF Ligand for E3 Ligase Molecular Glues Ligands for E3 Ligase inhibit Thalomid E3 ligase-recruiting Moiety Inhibitor Sedoval inhibitor