Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Iberdomide (CC-220) is a modulator of cereblon( IC50 value of 60 nM in a competitive TR-FRET assay).
説明 | Iberdomide (CC-220) is a modulator of cereblon( IC50 value of 60 nM in a competitive TR-FRET assay). |
ターゲット&IC50 | Cereblon:60 nM |
In vitro | Iberdomide has a greater potency for degrading the CRL4 complex substrates Ikaros and Aiolos (EC50s = 1 and 0.5 nM) but has no degradative activity for GSPT1 or CK1α[1]. |
別名 | CC-220 |
分子量 | 449.5 |
分子式 | C25H27N3O5 |
CAS No. | 1323403-33-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30 mg/mL (66.74 mM)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Iberdomide 1323403-33-3 Apoptosis PROTAC Ligand for E3 Ligase CELMoD H929 CRBN Ligands for E3 Ligase KMS12PE KMS11 orally sub-G1 CC 220 cereblon G0/G1 U266 multiple ligase Inhibitor Thalidomide RPM-8226 MM1.R MM1.S EJM KMS128M inhibit CC220 E3 ligase-recruiting Moiety myeloma CC-220 inhibitor