Powder: -20°C for 3 years | In solvent: -80°C for 1 year
(-)-Securinine (Securinine) is plant-derived alkaloid and also a GABAA receptor antagonist.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
5 mg | 在庫あり | ¥ 11,500 | |||
10 mg | 在庫あり | ¥ 19,000 | |||
25 mg | 在庫あり | ¥ 40,000 | |||
50 mg | 在庫あり | ¥ 58,500 | |||
100 mg | 在庫あり | ¥ 87,500 |
説明 | (-)-Securinine (Securinine) is plant-derived alkaloid and also a GABAA receptor antagonist. |
In vitro | (-)-Securinine significantly inhibits HeLa cells growth with IC50 values of 7.02±0.52 μg/mL (32.3 μM). (-)-Securinine induces apoptosis in a dose-dependent manner in the tested cells, increases the percentage of ROS positive cells and depolarized cells as well as stimulates the activity of ERK1/2, caspase-9 and -3/7. (-)-Securinine also induces cell cycle arrest in S phase. Real-time PCR analysis shows high expression of tumor necrosis factor receptor superfamily (TNFRSF) genes in the cells stimulated with (-)-Securinine. |
In vivo | In the tumor model, treatment with (-)-Securinine markedly inhibits tumor growth, suggesting its potential as an Acute Myeloid Leukemia (AML) treatment. Mice treated with (-)-Securinine (n=5 mice, bilateral tumors) show tumors that are, on average, over 75% smaller than those in vehicle-treated mice at the conclusion of the study. |
植物由来 |
別名 | Securinine |
分子量 | 217.26 |
分子式 | C13H15NO2 |
CAS No. | 5610-40-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 2 mg/mL (9.21 mM)
You can also refer to dose conversion for different animals. 詳細
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(-)-Securinine 5610-40-2 Membrane transporter/Ion channel Neuroscience GABA Receptor ()Securinine inhibit Inhibitor Securinine Gamma-aminobutyric acid Receptor ( ) Securinine γ-Aminobutyric acid Receptor inhibitor