Powder: -20°C for 3 years | In solvent: -80°C for 1 year
(E/Z)-BCI (NSC-150117), a dual-specificity phosphatase 6 (DUSP6) inhibitor with anti-inflammatory properties, reduces LPS-induced inflammatory mediators and ROS production in macrophage cells by activating the Nrf2 signaling axis and inhibiting the NF-κB pathway.
説明 | (E/Z)-BCI (NSC-150117), a dual-specificity phosphatase 6 (DUSP6) inhibitor with anti-inflammatory properties, reduces LPS-induced inflammatory mediators and ROS production in macrophage cells by activating the Nrf2 signaling axis and inhibiting the NF-κB pathway. |
In vitro | (E/Z)-BCI hydrochloride (2-10 μM; 72 hours) significantly decreases cell viability in a time and dose-dependent manner in gastric epithelial cell GES1, GC cell lines, and AGS cell lines. (E/Z)-BCI hydrochloride (0.5-4 μM; 24 hours) significantly inhibits DUSP6 expression in LPS-activated macrophages. (E/Z)-BCI hydrochloride inhibits cell proliferation, migration, and invasion in a receptor-independent manner and enhances Cisplatin (CDDP) cytotoxicity (enhances CDDP-induced cell death and apoptosis) at pharmacological concentrations in gastric cancer (GC) cells. (E/Z)-BCI hydrochloride (0.5-2 μM; 24 hours) treatment significantly inhibits the expression of IL-1β, TNF-α, and IL-6 mRNA in LPS-activated macrophages. (E/Z)-BCI hydrochloride decreases ROS production and activates the Nrf2 pathway in LPS-activated macrophages. |
In vivo | (E/Z)-BCI hydrochloride treatment enhances cisplatin efficacy in PDX models. |
別名 | NSC 150117 |
分子量 | 317.42 |
分子式 | C22H23NO |
CAS No. | 15982-84-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 20 mg/mL (60.00 mM), Sonication is recommended.
DMSO: 60 mg/mL (189.02 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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(E/Z)-BCI 15982-84-0 Apoptosis Metabolism Phosphatase NSC150117 ROS NSC 150117 death LPS gastric cancer anti-inflammatory NF-κB inhibit Inhibitor (E/Z) BCI Nrf2 (E/Z)BCI NSC-150117 ERK DUSP6 inhibitor