Powder: -20°C for 3 years | In solvent: -80°C for 1 year
(R)-Propranolol hydrochloride (Dexpropranolol hydrochloride) is the less active enantiomer of the anti-adrenoceptor (β-adrenoceptor) antagonist propranolol. Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist with a high affinity for β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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25 mg | 在庫あり | ¥ 8,000 | |||
50 mg | 在庫あり | お問い合わせ | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 11,500 |
説明 | (R)-Propranolol hydrochloride (Dexpropranolol hydrochloride) is the less active enantiomer of the anti-adrenoceptor (β-adrenoceptor) antagonist propranolol. Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist with a high affinity for β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively. |
ターゲット&IC50 | β2-adrenoceptor:0.8 nM(Ki), β1-adrenoceptor:1.8 nM(Ki) |
In vivo | Both isomers of propranolol are capable of preventing adrenaline-induced cardiac arrhythmias in cats anaesthetized with halothane and reversing ventricular tachycardia caused by ouabain in anaesthetized cats and dogs, but the dose of (-)-propranolol is significantly smaller than that of (+)-propranolol ((R)-Propranolol) in both species[4]. Administration of 10 mg/kg (R)-Propranolol hydrochloride has no antagonistic activity in rats, the cardiac responses to isoprenaline of rats can be blocked by probably much less than 1/100th of that of the (-) isomer in this preparation[4]. |
別名 | Dexpropranolol hydrochloride, (R)-(+)-Propranolol |
分子量 | 295.8 |
分子式 | C16H22ClNO2 |
CAS No. | 13071-11-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 14.79 mg/mL (50 mM), Sonication is recommended.
DMSO: 60 mg/ml (202.84 mM)
You can also refer to dose conversion for different animals. 詳細
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(R)-Propranolol hydrochloride 13071-11-9 GPCR/G Protein Neuroscience Adrenergic Receptor Inhibitor enantiomer Propranolol Beta Receptor Dexpropranolol hydrochloride (R)-(+)-Propranolol (R)-Propranolol Dexpropranolol Hydrochloride β-adrenoceptor cardiac arrhythmias (R)Propranolol hydrochloride (R) Propranolol hydrochloride inhibit Propranolol Hydrochloride inhibitor