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T12697 |
Refametinib R enantiomer
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RDEA119 R enantiomer,Refametinib R enantiomer,BAY 869766 R enantiomer |
MEK
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T12064 |
Niraparib (R-enantiomer)
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MK 4827 (R-enantiomer),Niraparib R-enantiomer |
PARP
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Niraparib R-enantiomer (MK 4827 R-enantiomer) is an inhibitor of PARP1(IC50 of 2.4 nM). |
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T7058 |
Selisistat S-enantiomer
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EX-527 S-enantiomer,EX-527 (S-enantiomer) |
Sirtuin
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Selisistat S-enantiomer (EX-527 S-enantiomer) is an effective and specific SIRT1 inhibitor (IC50 = 98 nM) and shows >200-fold selectivity against SIRT2/3. |
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T13140 |
Umbralisib R-enantiomer
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TGR-1202 R-enantiomer,RP5264 R-enantiomer |
PI3K
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Umbralisib R-enantiomer (RP5264 R-enantiomer) is a delta inhibitor of PI3K and a less active enantiomer of TGR-1202. The IC50 of Umbralisib R-enantiomers against δPI3 kinase is at least 20 times lower than that of the in... |
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T15263 |
Selisistat R-enantiomer
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EX-527 (R-enantiomer) |
Sirtuin
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Selisistat R-enantiomer (EX-527 (R-enantiomer)) is a SIRT1 inhibitor with much less activity than the R-enantiomer of Selisistat (IC50 of SIRT1 > 100 μM). |
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T11129L |
Duvelisib (R enantiomer) hydrochloride
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IPI-145 R enantiomer HCl,Duvelisib (R enantiomer) hydrochloride(1261590-48-0 Free base),INK1197 R enantiomer HCl |
PI3K
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Duvelisib (R enantiomer) hydrochloride (INK1197 R enantiomer HCl) is a PI3K inhibitor. Duvelisib (R enantiomer) hydrochloride is the less active enantiomer of Duvelisib. |
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T6156 |
Ruxolitinib (S enantiomer)
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S-Ruxolitinib,Ruxolitinib S enantiomer,INCB018424,INCB18424 |
Tyrosine Kinases
,
JAK
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Ruxolitinib S enantiomer (INCB18424) is the S-enantiomer of Ruxolitinib. Ruxolitinib is the first potent, selective JAK1/2 inhibitor. |
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T17102 |
Tipifarnib (S enantiomer)
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Tipifarnib S enantiomer,(S)-(-)-R-115777,(S)-Tipifarnib,IND-58359 S enantiomer |
Transferase
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Tipifarnib S enantiomer ((S)-(-)-R-115777) is the S-enantiomer of Tipifarnib. Tipifarnib is a potent and specific farnesyltransferase inhibitor (IC50: 0.6 nM). |
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T12831 |
SAR405 R enantiomer
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Others
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SAR405 R enantiomer is the less active enantiomer of SAR405. SAR405 is an inhibitor of PIK3C3/Vps34. |
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T19618 |
(R)-(-)-JQ1 Enantiomer
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Epigenetic Reader Domain
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(R)-(-)-JQ1 Enantiomer is the stereoisomer of (+)-JQ1. (+)-JQ1 is a BET bromodomain inhibitor, acting on BRD4(1/2)(IC50 of 77 nM/33 nM in a cell-free assay) |
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T19112L |
Sacubitril Enantiomer
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2R,4S-Sacubitril,ahu377 isomer 2 |
Others
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Sacubitril Enantiomer (ahu377 isomer 2) is the enantiomer of Sacubitril which is a neprilysin inhibitor. |
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T9825 |
CORT-108297 Enantiomer
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Others
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CORT-108297 Enantiomer is an enantiomer of CORT-108297 which is an antagonist of the Glucocorticoid Receptor. |
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T10819 |
Cipropride S enantiomer
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Others
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Cipropride S enantiomer is the S enantiomer of cipropride which is an antiemetic drug. |
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T7695 |
PNU-282987 S enantiomer free base
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AChR
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PNU-282987 S enantiomer free base is an agonist of α7 nicotinic acetylcholine receptor (α7 nAChR). |
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T67881 |
Acalabrutinib enantiomer
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R-Acalabrutinib |
BTK
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Acalabrutinib enantiomer (R-Acalabrutinib) is a chemical compound that belongs to the class of Bruton’s tyrosine kinase (BTK) inhibitors. Acarabitinib enantiomers can be used in the study of cancer, autoimmune diseases a... |
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T22450 |
Tyrphostin B44, (+) enantiomer
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EGFR
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Tyrphostin B44, (+) enantiomer is an inhibitor of epidermal growth factor receptor (EGFR) kinase with IC50 of 0.86 μM and has less active than the (-) enantiomer. |
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T80678 |
(S)-AK-242
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(-)-Resatorvid,(S)-Resatorvid,AK-242 (S enantiomer),(-)-AK-242 |
Others
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(S)-AK-242 ((S)-Resatorvid) is a cytokine inhibitor used in the treatment of heart disease, autoimmune disease, and inflammatory disease. |
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T10552 |
Bitopertin (R enantiomer)
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RO4917838 (R enantiomer),RG1678 (R enantiomer),Bitopertin R enantiomer |
GlyT
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Bitopertin R enantiomer (RG1678 R enantiomer) is the R-enantiomer of Bitopertin. Bitopertin is a noncompetitive glycine reuptake inhibitor and inhibits glycine uptake at human GlyT1 (IC50: 25 nM). |
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T11391 |
Gepotidacin S enantiomer
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GSK2140944 S enantiomer |
Others
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Gepotidacin S enantiomer is an S enantionmer of gepotidacin. |
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T11173 |
Elacestrant S enantiomer
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RAD1901 S enantiomer |
Others
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Elacestrant S enantiomer is a selective and orally available estrogen receptor (ERR) degrader with IC50 values of 48 and 870 nM for ERα and ERβ, respectively. |
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T11335 |
Fulvestrant (S enantiomer)
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ZM 182780 S enantiomer,ICI 182780 S enantiomer,Fulvestrant S enantiomer,ZD 9238 S enantiomer |
Others
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Fulvestrant S enantiomer is the less active S enantiomer of Fulvestrant. Fulvestrant is a potent estrogen receptor antagonist with an IC50 of 9.4 nM. |
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T10856 |
Cobimetinib (R-enantiomer)
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XL-518 R-enantiomer,Cobimetinib R-enantiomer,GDC-0973 R-enantiomer |
Others
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Cobimetinib R-enantiomer is the less active R-enantiomer of Cobimetinib which is a selective MEK inhibitor. |
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T67880 |
NITD-609 Enantiomer
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Others
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NITD-609 Enantiomer is an enantiomer of NITD-609 which is a spironone drug with antimalarial activity. |
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T13312 |
Seviteronel R enantiomer
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VT-464 (R enantiomer) |
Others
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Seviteronel R enantiomer is the R enantiomer of Seviteronel and is a potent inhibitor of CYP17 lyase (IC50: 69 nM for h-Lyase). |
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T11410 |
GLPG0492 (R enantiomer)
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GLPG0492 R enantiomer |
Others
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GLPG0492 R enantiomer is the R enantiomer of GLPG-0492, a novel selective androgen receptor modulator. |
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T12775 |
RSV604 (R enantiomer)
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RSV604 R enantiomer |
Others
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RSV604 R enantiomer is the R-enantiomer of RSV604. RSV604 is a respiratory syncytial virus (RSV) replication inhibitor. |
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T11156 |
Nazartinib S-enantiomer
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EGF816 (S-enantiomer) |
Others
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Nazartinib is an EGFR inhibitor. Nazartinib S-enantiomer is the less active S-enantiomer of Nazartinib. |
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T10465 |
Atuveciclib S-Enantiomer
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BAY-1143572 S-Enantiomer |
CDK
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Atuveciclib S-Enantiomer (BAY-1143572 S-Enantiomer) is the (S)-enantiomer of BAY-1143572. Atuveciclib S-Enantiomer is a potent and selective CDK9 inhibitor, which inhibits CDK9 / CycT1 with an IC 50 of 16 nM. |
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T12274 |
Siremadlin (R Enantiomer)
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Siremadlin R Enantiomer,HDM201 R Enantiomer,NVP-HDM201 R Enantiomer |
Others
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Siremadlin R Enantiomer is the R enantiomer of Siremadlin. Siremadlin is a potent and highly specific inhibitor of MDM-2/p53. |
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T13422L |
Talarozole (R enantiomer)
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(R)-Talarozole,Talarozole R enantiomer |
Others
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Talarozole R enantiomer is a potent and selective inhibitor of cytochrome P450 26-mediated breakdown of endogenous all-trans retinoic acid. |
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T11334 |
Fulvestrant (R enantiomer)
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ICI 182780 R enantiomer,ZD 9238 R enantiomer,ZM 182780 R enantiomer,Fulvestrant R enantiomer |
Others
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Fulvestrant R enantiomer is the less active R enantiomer of Fulvestrant. Fulvestrant is a potent estrogen receptor antagonist with an IC50 of 9.4 nM. |
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T11129 |
Duvelisib (R enantiomer)
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Duvelisib R enantiomer,IPI-145 R enantiomer,INK1197 R enantiomer |
PI3K
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Duvelisib R enantiomer (IPI-145 R enantiomer) is an enantiomer of Duvelisib with lower activity. Duvelisib is a PI3K inhibitor. |
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T12200 |
Firsocostat S enantiomer
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ND-630 S enantiomer,NDI-010976 S enantiomer,GS-0976 S enantiomer |
Others
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Firsocostat S enantiomer is the less active S enantiomer of Firsocostat. |
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T13120 |
Tenalisib R Enantiomer
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RP6530 R Enantiomer |
Others
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Tenalisib R Enantiomer is an R enantiomer of Tenalisib . |
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T9848 |
GSK2850163 (S enantiomer)
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IRE1
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GSK2850163 (S enantiomer) is the inactive enantiomer of GSK2850163. GSK2850163 is an novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1a). |
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T11628 |
IACS-8968 S-enantiomer
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IDO/TDO Inhibitor (S-enantiomer) |
IDO
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IACS-8968 S-enantiomer is the S-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and <5 for TDO). |
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T11627 |
IACS-8968 R-enantiomer
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IDO/TDO Inhibitor (R-enantiomer) |
IDO
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IACS-8968 R-enantiomer is the R-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and <5 for TDO). |
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T39541 |
THK5351 (R enantiomer)
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THK5351 R enantiomer is an R enantiomer of THK5351. |
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T11173L |
Elacestrant S enantiomer dihydrochloride
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RAD1901 S enantiomer dihydrochloride,RAD-1901 S enantiomer dihydrochloride,RAD 1901 S enantiomer dihydrochloride |
Others
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Elacestrant (RAD1901) dihydrochloride is a selective and orally available estrogen receptor (ERR) degrader with IC50 values of 48 and 870 nM for ERα and ERβ, respectively. Elacestrant S enantiomer dihydrochloride is an l... |
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T11662 |
INT-777 R-enantiomer
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S-EMCA R enantiomer |
Others
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INT-777 is the R-enantiomer of INT-777, less potent than INT-777,EC50 of 4.79 μM for TGR5. |
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T10252L |
ADU-S100 enantiomer ammonium salt
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MIW815 enantiomer ammonium salt,ML RR-S2 CDA enantiomer ammonium salt |
Others
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ADU-S100 (MIW815) enantiomer ammonium salt is the less active enantiomer of ADU-S100. ADU-S100 is an activator of the stimulator of interferon genes (STING). |
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T41114 |
LIN28 inhibitor LI71 enantiomer
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LIN28 inhibitor LI71 enantiomer, the enantiomer of LIN28 inhibitor LI71，exhibits reduced activity compared to its parent compound. LIN28 inhibitor LI71 is a highly potent and cell-permeable inhibitor of LIN28, effectivel... |
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T11195 |
Enantiomer of Sofosbuvir
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Others
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Sofosbuvir's enantiomer, a variant of the prescription medication Sofosbuvir used for chronic hepatitis C treatment, currently lacks reported biological activity. |
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T12915 |
Silvestrol aglycone (enantiomer)
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Others
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Silvestrol aglycone (enantiomer) is a cyclopenta benzofuran core phenol. |
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T11841 |
Leu-AMS R enantiomer
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Others
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Leu-AMS R enantiomer is the R enatiomer of Leu-AMS. Leu-AMS is a potent leucyl-tRNA synthetase (LRS) inhibitor that inhibits the bacteria growth. |
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T12203 |
Necrostatin 2 S enantiomer
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Others
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Necrostatin 2 S enantiomer is the S enantiomer of Necrostatin 2 |
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T11378 |
GDC-0834 S-enantiomer
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Others
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GDC-0834, the S-enantiomer, is a potent and selective inhibitor of Bruton's tyrosine kinase (BTK). |
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T11902 |
LY 344864 S-enantiomer
|
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Others
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LY 344864 S-enantiomer, the S-enantiomer of LY344864, serves as a 5-HT1F receptor agonist. |
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T12723 |
Ribocil-C R enantiomer
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Others
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Ribocil-C R enantiomer is the R enantiomer of Ribocil-C. Ribocil-C is a highly selective bacterial riboflavin riboswitches inhibitor. |
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T12067 |
MK-7246 S enantiomer
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Others
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MK-7246 S enantiomer is a potent and selective CRTH2 antagonist. |
