Powder: -20°C for 3 years | In solvent: -80°C for 1 year
(R)-Terazosin is an active R-enantiomer of Terazosin. (R)-Terazosin is a potent antagonist of α1-adrenoceptor (α1a, α1b and α1d-adrenoceptor with Ki values of 6.51 nM, 1.01 nM and 1.97 nM, respectively).
説明 | (R)-Terazosin is an active R-enantiomer of Terazosin. (R)-Terazosin is a potent antagonist of α1-adrenoceptor (α1a, α1b and α1d-adrenoceptor with Ki values of 6.51 nM, 1.01 nM and 1.97 nM, respectively). |
ターゲット&IC50 | α1D-adrenoceptor:1.97 nM (Ki), α1A-adrenoceptor:6.51 nM (Ki), α1B-adrenoceptor:1.01 nM (Ki) |
In vitro | (R)-Terazosin is low affinity for α2a, α2B and α2c-adrenoceptor(Ki of 3.85 μM, 0.33 μM and 0.37 μM, respectively). (R)-Terazosin may prove to be a useful probe in understanding the functional role of subtypes of adrenoceptors in various tissues. |
In vivo | (R)-Terazosin shows antagonism of at rat atrial α2B receptor (pEC30 : 5.69). (R)-Terazosin shows antagonism of at rat vas deferens α1A and α2A receptor (pA2 of 7.5 and 5.31, respectively). |
分子量 | 387.43 |
分子式 | C19H25N5O4 |
CAS No. | 109351-34-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 75 mg/mL (193.58 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
(R)-Terazosin 109351-34-0 GPCR/G Protein Neuroscience Adrenergic Receptor Terazosin α1-adrenoceptor affinity inhibit subtypes prove (R)Terazosin Inhibitor (R) Terazosin Low α2-adrenoceptor Beta Receptor inhibitor