|
T6923 |
Ozanimod
|
RPC-1063 |
S1P Receptor
,
LPL Receptor
|
|
Ozanimod (RPC-1063) (RPC1063) is a specific oral S1P Receptor 1 modulator. Ozanimod has been used in trials studying the treatment of Crohn's Disease, Ulcerative Colitis, Multiple Sclerosis, and Relapsing Multiple Sclero... |
|
T12643 |
(R)-Terazosin
|
|
Adrenergic Receptor
|
|
(R)-Terazosin is an active R-enantiomer of Terazosin. (R)-Terazosin is a potent antagonist of α1-adrenoceptor (α1a, α1b and α1d-adrenoceptor with Ki values of 6.51 nM, 1.01 nM and 1.97 nM, respectively). |
|
T26854 |
BMS641
|
BMS-641,BMS-209641,BMS 641 |
Retinoid Receptor
|
|
BMS641 (BMS-209641) is a selective and potent RARβ agonist.BMS641 has a high affinity for RARβ and synergistically activates RARβ and RARgamma to induce cellular maturation into specialized neuronal subtypes. |
|
T16936 |
SS-208
|
|
HDAC
|
|
SS-208 is a selective inhibitor of HDAC6 (IC50 = 12 nM) with anti-tumor activity. SS-208 shows selectivity over other HDAC subtypes. |
|
T15575 |
Indeglitazar
|
PPM 204 |
PPAR
|
|
Indeglitazar (PPM 204) is orally available pan-agonist of PPAR (PPAR subtypes alpha (α), delta (δ), and gamma (γ)). |
|
T6725 |
VU 0357121
|
|
GluR
|
|
VU0357121, a positive allosteric modulator of mGlu5 (EC50: 33 nM), is inactive or very weakly antagonizing at other mGlu receptor subtypes. |
|
T23331 |
SC 51089
|
SC 51089 free base |
Prostaglandin Receptor
|
|
SC 51089 is a selective prostaglandin receptor PGE2 antagonist with selectivity for prostaglandin receptor subtypes and antinociceptive activity that improves motor deficits and rescues memory decline in the Huntington's... |
|
T2542 |
Prucalopride
|
R-93877 |
5-HT Receptor
|
|
Prucalopride (R-93877) is a selective, high-affinity 5-HT4A/4B receptor agonist (Ki: 2.5/8 nM). It has >290-fold selectivity for 5-HT4A/4B receptor than other 5-HT receptor subtypes. |
|
T5858 |
Sertindole
|
Lu 23-174 |
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
,
Autophagy
|
|
Sertindole (Lu 23-174) is an atypical antipsychotic that binds to dopamine D2 receptors and the serotonin (5-HT) receptor subtypes 5-HT1D, 5-HT2A, and 5-HT2C (Kds = 2.7, 20, 0.14, and 6 nM, respectively) |
|
T11014 |
DFP00173
|
|
Aquaporin
|
|
|
|
T15816 |
LY341495
|
|
GluR
|
|
LY341495 is a potent metabotropic glutamate receptor antagonist that exhibits high activity against a wide range of glutamate receptor subtypes and can be used for the study of neurological disorders. |
|
T9683 |
VX-150
|
|
Sodium Channel
|
|
VX-150 is a highly selective NaV1.8 inhibitor relative to the other sodium channel subtypes (>400-fold). |
|
T1049 |
Oxybutynin chloride
|
Oxybutynin hydrochloride,Oxybutynin HCl |
Potassium Channel
,
AChR
|
|
Oxybutynin chloride (Oxybutynin HCl) is an anticholinergic medication used to relieve urinary and bladder difficulties. It competitively antagonizes the M1, M2, and M3 subtypes of the muscarinic acetylcholine receptor. |
|
T76907 |
Palivizumab
|
Synagis,MEDI 493 |
RSV
|
|
Palivizumab (MEDI 493) is a humanized RSV-specific monoclonal antibody that selectively inhibits epitopes at the F protein A antigenic site of RSV subtypes A and B for the prevention of respiratory syncytial virus infect... |
|
T2004 |
Ciproxifan maleate
|
FUB 359 maleate,FUB 359 |
Histamine Receptor
|
|
Ciproxifan maleate (FUB 359)(FUB-359 maleate) is a highly potent and selective histamin H3-receptor antagonist with IC50 of 9.2 nM, with low apparent affinity at other receptor subtypes. |
|
T4560 |
Alprenolol
|
Alpheprol,(RS)-Alprenolol,dl-Alprenolol |
5-HT Receptor
,
Adrenergic Receptor
|
|
Alprenolol (Alpheprol) is a non-selective β-adrenergic receptor (β-AR) antagonist that is also an antagonist of the serotonin (5-HT) receptor subtypes 5-HT1A and 5-HT1B. |
|
T76992 |
Suptavumab
|
REGN2222 |
RSV
|
|
Suptavumab (REGN2222) is a human monoclonal antibody. Suptavumab neutralizes conserved epitopes on subtypes A and B on RSV. Suptavumab can be used to study RSV infections and the respiratory system. |
|
T19940 |
Sulfoxaflor
|
GF 2372,GF 2032,XDE 208 |
AChR
|
|
Sulfoxaflor (GF 2032), an agonist of nAChR1 and nAChR2 subtypes, is a systemic insecticide that acts on the central nervous system of insects. Sulfoxaflor is used for the control of sap-feeding insects such as Nilaparvat... |
|
T6727 |
VU0364770
|
VU 0364770 |
GluR
|
|
VU0364770 (VU 0364770)(EC50=1.1 μM), a positive allosteric modulator(PAM) of mGlu4, shows insignificant activity at 68 other receptors, including other mGlu subtypes. |
|
T22301 |
L-838417 D9
|
CTP354,CTP354 (C-21191),C-21191 |
GABA Receptor
|
|
L-838417 D9 (C-21191) is a novel deuterated subtype-selective GABAA positive allosteric modulator, acting as a partial agonist at α2, α3 and α5 subtypes[1]. |
|
T11078 |
Deschloroclozapine
|
|
Serotonin Transporter
|
|
Deschloroclozapine, a metabolite of Clozapine, is a highly potent muscarinic DREADDs agonist. Deschloroclozapine binds to DREADD receptor subtypes hM3Dq and hM4Di with Ki of 6.3 and 4.2 nM, respectively. |
|
T1052 |
Proglumide
|
|
cholecystokinin
|
|
Proglumide (Binoside) is a cholecystokinin antagonist, which blocks both the CCKA and CCKB subtypes. Proglumide is a drug that exerts an inhibitory effect on gastric secretion and reduces gastrointestinal motility. It is... |
|
T14975 |
CJ-42794
|
CJ-042794 |
Others
|
|
CJ-42794 (CJ-042794) is a selective antagonist of prostaglandin E receptor subtype 4 (EP4). It inhibits [3H]-PGE2 binding to the human EP4 receptor (a mean pKi: 8.5). CJ-42794 is a binding affinity that was at least 200-... |
|
T10000 |
(±)-Tazifylline
|
|
Histamine Receptor
|
|
(±)-Tazifylline is a selective and long-acting antagonist of histamine H1 receptor. Tazifylline shows much lower affinity for H2 receptors, α- and β-adrenoceptors, 5-hydroxytryptamine and muscarinic receptor subtypes. |
|
T10432L |
AZD-8529 mesylate
|
|
GluR
|
|
AZD-8529 mesylate is a highly selective, and orally bioavailable positive allosteric modulator of mGluR2 (EC50: 285 nM). It shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 ... |
|
T39161 |
Ro60-0175
|
Ro60-0175 |
5-HT Receptor
|
|
Ro60-0175 a selective agonist for both the 5-hydroxytryptamine 2B (5-HT2B) and 5-hydroxytryptamine 2C (5-HT2C)serotonin receptor subtypes, commonly used as fumarate salt. It has a role as a 5-hydroxytryptamine 2B recept... |
|
T23515 |
VU-29
|
VU 29 |
GluR
|
|
VU-29 is a positive allosteric mGlu5 receptor modulator with EC50=9 nM and Ki=244 nM for rmGluR5. It is selective for mGluR5 relative to other mGluR subtypes (EC50: rmGluR1/rmGluR2=557 nM/1.5 μM; hmGluR4=154 nM). |
|
T15032 |
CYM50308
|
|
S1P Receptor
,
LPL Receptor
|
|
CYM50308 is a high affinity agonist of sphingosine-1-phosphate receptor 4 (S1P4-R) (EC50: 56 nM). CYM50308 has no activity at S1P1-R, S1P2-R and S1P3-R subtypes at concentrations up to 25 μM and it shows 37-fold more sel... |
|
T11061 |
DMCM hydrochloride
|
|
GABA Receptor
|
|
DMCM hydrochloride is a non-selective fully inverse agonist of benzodiazepine. DMCM showed significant differences in human recombinant GABAA αxβ3γ2 receptor subtypes. For α1, α2, α3, and α5 receptors, their Kis were 10 ... |
|
T60616 |
MPT0G211
|
|
HDAC
|
|
MPT0G211 is a highly selective and orally active HDAC6 inhibitor (IC50=0.291 nM) that has neuroprotective effects and has shown anti-metastatic activity in human breast cancer cells. MPT0G211 has 1,000 times more affinit... |
|
T19965 |
Dacomitinib hydrate
|
PF 299804,PF00299804,PF 00299804,PF-00299804,PF299804,PF-299804 |
EGFR
|
|
Dacomitinib hydrate (PF 299804) is a highly selective and second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor family of tyrosine kinases. Dacomitinib specifically and irreversibly binds... |
|
T2531L |
Eprosartan
|
KF-108566J free base,Teveten |
RAAS
|
|
Eprosartan (SKF-108566J free base) is a selective and competitive nonpeptide angiotensin II receptor antagonist with high affinity for AT1 receptor subtypes and can be used as an antihypertensive agent.Eprosartan has an ... |
|
T9657 |
FiVe1
|
|
Others
|
|
FiVe1 is a vimentin binding small molecule that promotes the disintegration and phosphorylation of vimentin in the metaphase, leading to mitotic disasters, polynuclearization, and loss of cancer cell dryness. FiVe1 selec... |
|
T6602 |
Naratriptan hydrochloride
|
Naratriptan HCl,Amerge,Naramig,GR-85548A hydrochloride |
5-HT Receptor
|
|
Naratriptan Hydrochloride is the hydrochloride salt form of naratriptan, a sulfonamide with selective serotonin (5-HT) 1 receptor agonistic activity and anti-migraine property. Naratriptan hydrochloride (GR-85548A hydroc... |
|
T26873 |
BMY-27709
|
BMY 27709,BMY27709 |
Influenza Virus
|
|
BMY-27709 is an influenza virus growth inhibitor with an IC50 value of 3-8 μM against A/WSN/33 virus growth, and also exhibits inhibitory activity against some subtypes of influenza viruses.BMY-27709 acts early in the co... |
|
T22540L |
Ac-Endothelin-1 (16-21), human acetate
|
|
Others
|
|
Ac-Endothelin-1 (16-21), human acetate, the principal peptide of the endothelin family, has been shown to have a variety of biological activities in both vascular and nonvascular tissues. The C-terminal fragment, which i... |
|
T0162 |
Quetiapine
|
ICI204636,Quetiapin |
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
,
AChR
,
Histamine Receptor
|
|
Quetiapine (ICI204636) is used for the therapy of schizophrenia, and for the treatment of acute manic episodes associated with bipolar I disorder. The mechanism of quetiapine' action is thought by mediated through antago... |
|
T15286 |
Flindokalner
|
BMS-204352 |
Potassium Channel
|
|
Flindokalner (BMS-204352) is a potassium channel modulator and a positive modulator of all neuronal Kv7 channel subtypes expressed in HEK293 cells. Flindokalner is a large conductance calcium-activated K channel (BKca) p... |
|
T4612 |
NS309
|
|
EGFR
,
Potassium Channel
,
HER
|
|
NS309 is a nonselective activator of small- and intermediate-conductance Ca2+-activated K+ (SK/KCa2 and IK/KCa3.1) channels (EC50s range from 0.12-1.2 µM for SK channels and 10-90 nM for IK channels). It can also activat... |
|
T28946 |
Tenofovir exalidex
|
Tenofovir,HDP-Tenofovir,CMX-157,CMX157,CMX 157 |
Antiviral
|
|
Tenofovir exalidex (CMX 157) is a lipid-conjugated acyclic nucleotide analog of Tenofovir, demonstrating efficacy against wild-type and antiretroviral-resistant HIV strains, including those resistant to multiple nucleosi... |
|
T6707 |
Tiotropium Bromide hydrate
|
BA-679 BR hydrate,BA 679BR |
AChR
|
|
Tiotropium Bromide hydrate (BA-679 BR hydrate) is a potent anticholinergic and bronchodilator, serving as a muscarinic receptor antagonist, specifically targeting mAChR. It is developed for treating chronic obstructive a... |
|
T12526 |
PP7
|
|
Influenza Virus
|
|
PP7 is a potent inhibitor of PB1-PB2 interaction(IC50 of 8.6 μM). |
|
T71950 |
PSB-12054
|
|
|
|
PSB-12054 is a potent P2X4 receptor inhibitor. PSB-12054 has IC(50) of 0.189 μM and good selectivity versus the other human P2X receptor subtypes. |
|
T28631 |
RX821002
|
RX-821002,RX 821002 |
|
|
RX821002 is a potent and selective antagonist of α2-adrenoceptor with low affinity for imidazoline sites. RX821002 displays selectivity for the α2D over the α2A subtypes (pKd values are 9.7 and 8.2 respectively). |
|
T10996 |
Deramciclane
|
EGIS-3886 |
5-HT Receptor
|
|
Deramciclane has high affinity for 5-HT2A and 5-HT2C receptors. It acts as an antagonist in both receptor subtypes and has inverse agonist properties for 5-HT2C receptors, but no direct stimulant agonists. |
|
T26419 |
A 53693
|
A-53693,A53693 |
|
|
A 53693 is a rigid catecholamine and a selective adrenergic agonist. A 53693 has affinity to certain alpha receptor subtypes in rat alpha-2 receptors. |
|
T16563 |
Pozanicline
|
ABT-089 |
AChR
|
|
Pozanicline reverses nicotine withdrawal-induced cognitive deficits, may be an effective component of novel therapeutic strategies for nicotine addiction. Pozanicline selectively activate neuronal nicotinic acetylcholine... |
|
T71822 |
B-TPMF
|
|
|
|
B-TPMF is the first small-molecule inhibitor with significant selectivity among the KCa2 channel subtypes. |
|
T30254 |
AZD-2327
|
|
|
|
AZD-2327 is a highly selective agonist of Δ-opioid receptor, highly selective to human μ-and κ-opioid receptor subtypes (> 1000 times) and 130 other receptors and channels of >. |
|
T27059 |
CP-122288
|
|
|
|
CP-122288 is a potent and selective agonist for the 5-HT1B, 5-HT1D and 5-HT1F serotonin receptor subtypes. CP-122288 is potent as an inhibitor of plasma protein extravasation and neurogenic inflammation. |
