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T0680 |
Lamotrigine
|
LTG,BW430C |
5-HT Receptor
,
Sodium Channel
,
Autophagy
|
|
Lamotrigine (BW430C) is an Anti-epileptic Agent and Mood Stabilizer. The physiologic effect of lamotrigine is by means of Decreased Central Nervous System Disorganized Electrical Activity. |
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T8963 |
CYM2503
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Neuropeptide Y Receptor
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CYM2503 is a positive allosteric modulator (PAM) of the GAL2 receptor that potentiates galanin-induced IP1 production in vitro. It has no affinity for the orthosteric galanin binding site of the receptor (as measured by ... |
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T22746 |
Tesmilifene fumarate
|
DPPE fumarate |
Histamine Receptor
|
|
Tesmilifene fumarate (DPPE fumarate) (DPPE fumarate) is an H1C receptor antagonist。 |
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T3563 |
Lvguidingan
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Others
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|
Lvguidingan is an Anticonvulsant agent. |
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T11908 |
LY2365109 hydrochloride
|
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GlyT
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LY2365109 hydrochloride is a potent and selective GlyT1 inhibitor, with an IC50 of 15.8 nM for glycine uptake in cells over-expressing hGlyT1a. |
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T0786 |
Clidinium bromide
|
Ro 2-3773 |
AChR
|
|
Clidinium bromide (Ro 2-3773) , a synthetic anticholinergic agent, has been shown in experimental and clinical researchers to have a pronounced antisecretory and antispasmodic effect on the gastrointestinal tract. It can... |
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TP1187 |
C-Type Natriuretic Peptide (CNP) (1-22), human
|
CNP (1-22), human |
RAAS
|
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C-Type Natriuretic Peptide (CNP) (1-22), human is the 1-22 fragment of C-Type Natriuretic Peptide. |
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T0267 |
Zonisamide
|
AD 810,CI 912 |
Calcium Channel
,
Sodium Channel
,
Carbonic Anhydrase
|
|
Zonisamide (AD 810), a sulfonamide anticonvulsant, is approved for use as an adjunctive treatment in adults with partial-onset seizures. It may inhibit a carbonic anhydrase although this is not one of the main mechanisms... |
|
T16801 |
(RS)-(Tetrazol-5-yl)glycine
|
LY 285265,D,L-(tetrazol-5-yl)glycine |
NMDAR
,
iGluR
|
|
(RS)-(Tetrazol-5-yl)glycine (LY 285265) (D,L-(tetrazol-5-yl)glycine) is an effective and selective N-methyl-D-aspartate receptor agonist. (RS)-(Tetrazol-5-yl)glycine has EC50s of 99 nM, 1.7 μM for GluN1/GluN2D, and GluN1... |
|
T10774 |
CFM-2
|
|
iGluR
|
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CFM-2, a potent and selective non-competitive antagonist of AMPAR (AMPAR), exhibits anticonvulsant activity across various seizure models. |
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T2523 |
Rufinamide
|
CGP 33101,E 2080,RUF 331 |
Sodium Channel
|
|
Rufinamide (E 2080), a triazole derivative, is used as voltage-gated sodium channel blocker for the treatment of seizure disorders. |
|
T16977 |
Talampanel
|
GYKI-53773,LY-300164 |
Apoptosis
,
GluR
|
|
Talampanel (LY-300164) is an orally and selective α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor antagonist with anti-seizure activity. Talampanel (IVAX) has neuroprotective effects in rodent stroke models. |
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T38808 |
Cyclamic acid sodium
|
Cyclohexylsulfamicacidsodium,Sodiumcyclamate |
Carbonic Anhydrase
|
|
Cyclamic acid sodium (Cyclohexylsulfamicacidsodium) is a carbonic anhydrase inhibitor and one of the most widely used artificial sweeteners in food and pharmaceuticals.Cyclamic acid sodium shows moderate anticonvulsant a... |
|
T24167 |
Inflachromene
|
ICM |
Others
|
|
Inflachromene (ICM) is an inhibitor of HMGB1 and HMGB expression with anti-inflammatory activity.Inflachromene reduces seizure severity in a mouse model of epilepsy by inhibiting HMGB1 translocation, inhibits endothelial... |
|
T0939 |
Phenytoin
|
Diphenylhydantoin,5,5-Diphenylhydantoin |
Virus Protease
,
Sodium Channel
|
|
Phenytoin (5,5-Diphenylhydantoin) is a hydantoin derivative and a non-sedative antiepileptic agent with anticonvulsant activity. Phenytoin potentially acts by promoting sodium efflux from neurons located in the motor cor... |
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T11800 |
L-803087
|
|
Somatostatin
|
|
|
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T38294 |
4-Deoxypyridoxine hydrochloride
|
|
S1P Receptor
|
|
4-Deoxypyridoxine (4-DPD) is a vitamin B6 antimetabolite with diverse biological activities. It inhibits transport of pyridoxine , pyridoxal, and pyridoxamine in and reduces growth of S. carlsbergensis cells. 4-DPD inhib... |
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T71956 |
Pimprinine
|
|
|
|
Pimprinine is an alkaloid. It is a potent inhibitor of MAO (monoamine oxidase). More recently, pimprinine showed promising anticonvulsant activity in electric seizure threshold. |
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T37119 |
1,2,3-Trioctanoyl-rac-glycerol-13C3
|
1,2,3-Trioctanoyl-rac-glycerol-13C3 |
|
|
1,2,3-Trioctanoyl-rac-glycerol-13C3 is intended for use as an internal standard for the quantification of 1,2,3-trioctanoyl-rac-glycerol by GC- or LC-MS. 1,2,3-Trioctanoyl-rac-glycerol is a triacylglycerol that contains ... |
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T69202 |
NBQX sodium
|
|
|
|
NBQX, also known as FG9202, is an AMPA receptor antagonist. NBQX blocks AMPA receptors in micromolar concentrations (~10–20 µM) and also blocks kainate receptors. In experiments, it is used to counter glutamate excitotox... |
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T38224 |
2,3-Dehydro-2-deoxy-N-acetylneuraminic acid
|
|
|
|
N-acetyl-2,3-dehydro-2-Deoxyneuraminic acid (DANA) is an inhibitor of human neuriminidases (sialidases) NEU1-4 (IC50s = 143, 43, 61, and 74 μM, respectively). In vivo, DANA (30 μL of a 5 mM solution) reduces latency to f... |
|
T82057 |
Iota-conotoxin RXIA
|
|
|
|
Iota-conotoxin RXIA, an agonist of voltage-gated sodium channels (Na v 1.2, 1.6, 1.7), has been shown to induce repetitive action potentials and seizure in the motor axons of frogs following intracranial injection in mic... |
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T37950 |
2-(Isopentylamino)naphthalene-1,4-dione
|
|
|
|
2-(Isopentylamino)naphthalene-1,4-dione is a vitamin K analog.1It inhibits spasms induced by pentylenetetrazole and tonic hindlimb extension induced by maximal electroshock (MES) in mice (ED50s = 349.2 and 108.1 mg/kg, r... |
|
T60492 |
Lamotrigine hydrate
|
|
|
|
Lamotrigine hydrate is an effective oral active anticonvulsant or antiepileptic agent that selectively blocks voltage-gated Na + channels, stabilizes presynaptic neuronal membranes and inhibits glutamate release. Lamotri... |
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T79804 |
5-HT2 agonist-1
|
|
5-HT Receptor
|
|
Compound 24, a 5-HT2 agonist-1, selectively activates 5-HT2A, 5-HT2B, and 5-HT2C receptors with IC50 values of 10 nM, 8.3 nM, and 1.6 nM, respectively. The free base form of this compound is utilized in research pertaini... |
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T79805 |
5-HT2 agonist-1 free base
|
|
5-HT Receptor
|
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Compound 24 (5-HT2 agonist-1 free base) is a potent agonist for 5-HT2A, 5-HT2B, and 5-HT2C receptors, exhibiting IC50 values of 10 nM, 8.3 nM, and 1.6 nM, respectively. It is utilized in research pertaining to depression... |
|
T79806 |
5-HT2A&5-HT2C agonist-1
|
|
5-HT Receptor
|
|
5-HT2A&5-HT2C agonist-1 (Example 2) is a dual-acting agent targeting the 5-HT2A and 5-HT2C receptors with respective IC50 values of 196 nM and 0.9 nM. It is applicable in the study of various central nervous system disor... |
|
TMIH-0523 |
Sodium cyclamate-d4
|
|
|
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Sodium cyclamate-d4 is a deuterated compound of Sodium cyclamate. Sodium cyclamate has a CAS number of 139-05-9. Cyclamic acid sodium is a carbonic anhydrase inhibitor and one of the most widely used artificial sweetener... |
|
T70063 |
GYKI 52466 HCl
|
|
|
|
GYKI 52466 is an allosteric AMPA receptor antagonist. It selectively inhibits AMPA-induced inward currents (IC50 = 7.5 µM) over NMDA- or GABA-induced inward currents in primary rat hippocampal neurons at 50 µM but also i... |
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T37215 |
5α,6β-Dihydroxycholestanol
|
|
|
|
5α,6β-Dihydroxycholestanol is an oxysterol metabolite of cholesterol formed from conversion of cholesterol epoxides by 5,6-epoxysterol hydrolase. It inhibits NMDA-mediated calcium influx in HEK293 cells expressing NR1/NR... |
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T37847 |
Zonisamide-13C2,15N
|
Zonisamide-13C2,15N |
|
|
Zonisamide-13C2,15N is intended for use as an internal standard for the quantification of zonisamide by GC- or LC-MS. Zonisamide is an antiepileptic agent.1 It selectively inhibits the repeated firing of sodium channels ... |
