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カタログ番号	製品名	別名	ターゲット
T12234	NMDA-IN-1		NMDAR
	NMDA-IN-1 is a potent and NR2B-selective antagonist of NMDA(NMDA Ki of 0.85 nM; NR2B Ca2+ influx IC50 is 9.7 nM).		NMDAR
T23014	MNI-caged-NMDA		Others
	NMDA caged with the photosensitive 4-methoxy-7-nitroindolinyl group		Others
T40999	NMDA receptor antagonist 2
	NMDA receptor antagonist 2 is a highly potent and orally active NR2B subtype-selective antagonist of the N-methyl-D-aspartate (NMDA) receptor. It exhibits remarkable binding affinities, with an IC50 of 1.0 nM and a Ki va...
T23165	PMPA (NMDA antagonist)		Others
	PMPA (NMDA antagonist) is a Competitive NMDA receptor antagonist.		Others
T60792	NMDA receptor antagonist-3
	NMDA receptor antagonist-3 is a NMDA receptor antagonist with a significan recovery rate (40.0%, at 100 μM) and safe toxicological characteristics in SH-SY5Y and human adipose mesenchymal stem cells.
T79374	NMDA receptor antagonist 7		iGluR
	Compound (S)-10a, a GluN2B subunit-selective NMDA receptor antagonist, exhibits a K i of 93 nM and an IC 50 of 72 nM. It is potentially useful for research into neurodegenerative diseases [1].		iGluR
T79375	NMDA receptor antagonist 8		iGluR
	Compound (R)-10a, an NMDA receptor antagonist, exhibits selectivity for the GluN2B subunit, possessing a Ki of 265 nM and an IC50 of 62 nM. This compound is utilized in research pertaining to neurodegenerative diseases [...		iGluR
T60513	NMDA-IN-2
	NMDA-IN-2 (compound 6b) is a Procaine derivative that is an inhibitor of NMDA receptor 2B subtype [1].
T61924	NMDA receptor modulator 6
	NMDA receptor regulator 6 (Compound 183) is an effective NMDA receptor regulator and has research value in neurological disorders.
T79273	NMDA receptor antagonist 6		iGluR
	NMDA Receptor Antagonist 6 (Compound 13b) functions as an antagonist at the glycine-binding site of the NMDA receptor and demonstrates cytoneuroprotective efficacy. It safeguards PC12 cells from NMDA-induced damage and a...		iGluR
T60685	NMDA receptor modulator 3
	NMDA receptor modulator 3 (Compound 99) is a potent modulator of NMDA receptor that can be used in the research of neurological disorder [1].
T63003	NMDA receptor potentiator-1
	NMDA receptor potentiator-1 (Compound 1368) is a subunit-selective NMDA receptor enhancer with IC50 values of 4 μM and 5 μM for NR2C and NR2D expression, respectively.
T61470	NMDA receptor antagonist 5
	NMDA receptor antagonist 5 (Compound 10e), a potent and non-toxic NMDA receptor antagonist, exhibits brain permeability. It is of significance in studying neurological disorders [1].
T61117	NMDA receptor modulator 5
	NMDA receptor modulator 5 (Compound 195), a potent NMDA receptor modulator, exhibits potential for neurological disorder research [1].
T60552	NMDA receptor modulator 2
	NMDA receptor modulator 2 (Compound 1) is a potent modulator of the NMDA receptor that can be used for neurological disorder research [1].
T60960	NMDA receptor modulator 4
	NMDA receptor modulator 4 (Compound 169) can be used for the research of neurological disorder that is a potent modulator of NMDA receptor [1].
T60306	NMDA receptor antagonist 4
	NMDA receptor antagonist 4 (IIc) is an uncompetitive, voltage-dependent, orally active NMDAR blocker, with an IC 50 of 1.93 μM. NMDA receptor antagonist 4 shows a positive predicted blood-brain-barrier (BBB) permeability...
T1896	Ro 61-8048		Hydroxylase
	Ro 61-8048 is a potent and selective inhibitor of kynurenine hydroxylase with an IC50 value of 37 nM.		Hydroxylase
T9626	Cycloleucine		NMDAR
	Cycloleucine is an antagonist of NMDA receptor associated glycine receptor with a Ki of 600 μM. Cycloleucine is also a competitive inhibitor of S-adenosyl-methionine mediated methylation with anxiolytic and cytostatic ef...		NMDAR
T8458	CNQX disodium		iGluR
	CNQX disodium is a competitive non-NMDA receptor antagonist and competitive AMPA/kainate receptor antagonist in neuronal cultures.		iGluR
T25196	BZAD01	BZAD-01,BZAD 01	NMDAR
	BZAD01 is a selective NMDA NR1A/2B receptor antagonist.		NMDAR
T1787	Levobupivacaine		Sodium Channel
	Levobupivacaine is an amino-amide local anaesthetic drug belonging to the family of n-alkylsubstituted pipecoloxylidide. It is the S-enantiomer of bupivacaine. Levobupivacaine hydrochloride is commonly marketed by AstraZ...		Sodium Channel
T8459	DNQX disodium salt	DNQX Disodium	NMDAR , iGluR
	DNQX disodium salt is a water-soluble form of selective antagonist of non-NMDA receptor		NMDAR , iGluR
T9133	Caroverine hydrochloride	Caroverine HCL	GluR , NMDAR , iGluR
	Caroverine hydrochloride (Caroverine HCL) is a potent, competitive and reversible antagonist of NMDA and AMPA glutamate receptor. It is also an antioxidant and calcium-blocking agent that exhibits vasorelaxant action, an...		GluR , NMDAR , iGluR
T22542	1-Aminocyclobutanecarboxylic acid	ACBC	NMDAR , iGluR
	1-Aminocyclobutanecarboxylic acid (ACBC) is a NMDA receptor partial agonist. 1-Aminocyclobutanecarboxylic acid act at the glycine site, NR1[1].		NMDAR , iGluR
T7304	DNQX	FG 9041	GluR , iGluR
	DNQX (FG 9041) is a competitive, non-NMDA glutamate receptor antagonist (IC50s = 0.5 and 0.1 μM for AMPA and kainate receptors, respectively)		GluR , iGluR
T4979	Procyclidine hydrochloride	(±)-Procyclidine hydrochlorid	NMDAR , iGluR
	Procyclidine hydrochloride ((±)-Procyclidine hydrochlorid) is a potent anticholinergic agent and also have NMDA antagonist properties.		NMDAR , iGluR
T4113	NBQX	FG9202,NBQX disodium salt	GluR , iGluR
	NBQX (FG9202) is a potent, selective and competitive AMPA receptor antagonist. Neuroprotective and anticonvulsant; active in vivo.		GluR , iGluR
T8937	Soticlestat	TAK-935,OV935	P450
	Soticlestat (OV935) is a potent, selective and orally active cholesterol 24-hydroxylase (CYP46A1) inhibitor. It has the potential for epilepsy syndromes research.		P450
T2003	ISX-9	Isoxazole 9,Isoxazole 9 (ISX-9)	Calcium Channel , Wnt/beta-catenin
	ISX-9 (Isoxazole 9) is necessary to activate neuron-specific genes as neurogenesis inducer.		Calcium Channel , Wnt/beta-catenin
T7178	CNQX	FG9065	GluR , iGluR
	CNQX (FG9065) is a competitive, non-NMDA glutamate receptor antagonist (IC50s = 0.3 and 1.5 μM for AMPA and kainate receptors, respectively)		GluR , iGluR
T6134	IEM 1754 2HBr	IEM 1754 dihydrobromide	GluR
	IEM 1754 2HBr (IEM 1754 dihydrobromide) is a selective AMPA/kainate receptor blockers for GluR1 and GluR3 with IC50 of 6 μM.		GluR
T0030	Bupivacaine hydrochloride	Vivacaine,Bupivacaine HCl	Sodium Channel
	Bupivacaine hydrochloride (Vivacaine) is a long-acting, amide-type local anesthetic. Bupivacaine hydrochloride reversibly binds to specific sodium ion channels in the neuronal membrane, resulting in a decrease in the vol...		Sodium Channel
T9157	GP130 receptor agonist-1	N-(4-Fluorophenyl)-4-phenyl-2-thiazolami	Interleukin
	GP130 receptor agonist-1 (N-(4-Fluorophenyl)-4-phenyl-2-thiazolami) is a potent, brain-penetrant and orally active GP130 receptor agonist.		Interleukin
T22517	5,7-Dichlorokynurenic acid	5,7-dichlorokynurenic acid sodium,5,7-DCKA	NMDAR
	5,7-Dichlorokynurenic acid (5,7-dichlorokynurenic acid sodium) is an NMDA receptor antagonist.		NMDAR
T16801	(RS)-(Tetrazol-5-yl)glycine	LY 285265,D,L-(tetrazol-5-yl)glycine	NMDAR , iGluR
	(RS)-(Tetrazol-5-yl)glycine (LY 285265) (D,L-(tetrazol-5-yl)glycine) is an effective and selective N-methyl-D-aspartate receptor agonist. (RS)-(Tetrazol-5-yl)glycine has EC50s of 99 nM, 1.7 μM for GluN1/GluN2D, and GluN1...		NMDAR , iGluR
T22674	Co 101244 hydrochloride	4-Piperidinol, 1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-Methylphenyl)Methyl]-,hydrochloride	NMDAR
	Co 101244 hydrochloride (4-Piperidinol, 1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-Methylphenyl)Methyl]-,hydrochloride) is an NR2B-containing NMDA receptor antagonist.		NMDAR
T6566	Levobupivacaine hydrochloride	Levobupivacaine HCl,(S)-(-)-Bupivacaine HCl,(S)-(-)-Bupivacaine monohydrochloride	Sodium Channel
	Levobupivacaine hydrochloride ((S)-(-)-Bupivacaine monohydrochloride) is a reversible neuronal sodium channel inhibitor, which is the pure S(-)-enantiomer of bupivacaine. It was utilized as a long-acting local anesthetic...		Sodium Channel
T6352	(-)-Dizocilpine maleate	C13737,(-)-MK 801 (Maleate),(-)-MK 801 Maleate	NMDAR , iGluR
	(-)-Dizocilpine maleate ((-)-MK 801 (Maleate)) is a potent, selective and non-competitive NMDA receptor antagonist with Kd of 37.2 nM in rat brain membranes.		NMDAR , iGluR
T15684	L-689560		NMDAR , iGluR
	L-689560 is widely used as a radiolabeled ligand in binding studies and used to study the roles of NMDA receptors in normal neurological processes as well as in diseases. At the GluN1 glycine binding site, L-689560 is an...		NMDAR , iGluR
T16800	(RS)-AMPA	(±)-AMPA	iGluR
			iGluR
T72662	NMDAR/TRPM4-IN-2		ERK , TRP/TRPV Channel , NMDAR , iGluR
	NMDAR/TRPM4-IN-2 is a potent interfacial inhibitor of NMDAR/TRPM4 interaction.NMDAR/TRPM4-IN-2 protects against MCAO-induced brain damage and NMDA-induced retinal ganglion cell loss in mice.NMDAR/TRPM4-IN-2 has neuroprot...		ERK , TRP/TRPV Channel , NMDAR , iGluR
T5522	NMDAR antagonist 1		Others , iGluR
	NMDAR antagonist 1 is an orally active, NR2B-selective NMDAR antagonist.		Others , iGluR
T61451	NMDAR/HDAC-IN-1
	NMDAR/HDAC-IN-1 (Compound 9d) is a potent dual inhibitor of N-methyl-D-aspartate receptors (NMDARs) and histone deacetylases (HDACs). It exhibits a high affinity (Ki = 0.59 μM) for NMDARs, while demonstrating significant...
T62126	(Rac)-NMDAR antagonist 1
	(Rac)-NMDAR antagonist 1 is a racemate of NMDAR antagonist 1. NMDAR antagonist 1 is a potent, orally active, NR2B-selective NMDAR antagonist.
T74854	GluN2B-NMDAR antagonist-1
	GluN2B-NMDAR Antagonist-1, an orally active compound, functions as a GluN2B-NMDAR antagonist with neuroprotective properties. It is applicable in the research of ischemic injury [1].
T10930	D-AP5	D-APV,D-2-Amino-5-phosphonovaleric acid	NMDAR , iGluR
	D-AP5 (D-APV) is a NMDA receptor antagonist.		NMDAR , iGluR
T1897	MDL-29951		NMDAR , iGluR
	MDL-29951 is a novel glycine antagonist of NMDA receptor activation.		NMDAR , iGluR
T6259	Dizocilpine	MK-801	NMDAR , iGluR
	MK-801 (Dizocilpine (MK-801)) is a potent N-methyl-D-aspartate (NMDA) receptor antagonist with Ki of 30.5 nM.		NMDAR , iGluR
T1751	Eliprodil	SL-820715	NMDAR , iGluR
	Eliprodil (SL-820715)(SL-820715), a non-competitive NR2B-NMDA receptor antagonist(IC50: 1 uM), less effective for NR2A- and NR2C-containing receptors(IC50> 100 uM). It has been used in trials studying the treatment of Pa...		NMDAR , iGluR

Compounds

NMDA receptor antagonist 2

T40999

Synonym:

Target:

PMPA (NMDA antagonist)

T23165

Synonym:

Target: Others

NMDA receptor antagonist-3

T60792

Synonym:

Target:

NMDA receptor antagonist 7

T79374

Synonym:

Target: iGluR

NMDA receptor antagonist 8

NMDA receptor modulator 6

T61924

Synonym:

Target:

NMDA receptor antagonist 6

T79273

Synonym:

Target: iGluR

NMDA receptor modulator 3

T60685

Synonym:

Target:

NMDA receptor potentiator-1

T63003

Synonym:

Target:

NMDA receptor antagonist 5

T61470

Synonym:

Target:

NMDA receptor modulator 5

T61117

Synonym:

Target:

NMDA receptor modulator 2

T60552

Synonym:

Target:

NMDA receptor modulator 4

T60960

Synonym:

Target:

NMDA receptor antagonist 4

Synonym: BZAD-01,BZAD 01

Target: Sodium Channel

DNQX disodium salt

T8459

Synonym: DNQX Disodium

Target: NMDAR, iGluR

Caroverine hydrochloride

T9133

Synonym: Caroverine HCL

Target: GluR, NMDAR, iGluR

1-Aminocyclobutanecarboxylic acid

T22542

Synonym: ACBC

Target: NMDAR, iGluR

Procyclidine hydrochloride

T4979

Synonym: (±)-Procyclidine hydrochlorid

Target: NMDAR, iGluR

NBQX

T4113

Synonym: FG9202,NBQX disodium salt

Target: GluR, iGluR

Soticlestat

T8937

Synonym: TAK-935,OV935

Target: P450

ISX-9

T2003

Synonym: Isoxazole 9,Isoxazole 9 (ISX-9)

Target: Calcium Channel, Wnt/beta-catenin

Synonym: IEM 1754 dihydrobromide

Target: GluR

Bupivacaine hydrochloride

T0030

Synonym: Vivacaine,Bupivacaine HCl

Target: Sodium Channel

GP130 receptor agonist-1

T9157

Synonym: N-(4-Fluorophenyl)-4-phenyl-2-thiazolami

Target: Interleukin

5,7-Dichlorokynurenic acid

T22517

Synonym: 5,7-dichlorokynurenic acid sodium,5,7-DCKA

Target: NMDAR

(RS)-(Tetrazol-5-yl)glycine

T16801

Synonym: LY 285265,D,L-(tetrazol-5-yl)glycine

Target: NMDAR, iGluR

Co 101244 hydrochloride

T22674

Synonym: 4-Piperidinol, 1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-Methylphenyl)Methyl]-,hydrochloride

Target: NMDAR

Levobupivacaine hydrochloride

T6566

Synonym: Levobupivacaine HCl,(S)-(-)-Bupivacaine HCl,(S)-(-)-Bupivacaine monohydrochloride

Target: Sodium Channel

(-)-Dizocilpine maleate

T6352

Synonym: C13737,(-)-MK 801 (Maleate),(-)-MK 801 Maleate

Target: NMDAR, iGluR

L-689560

T15684

Synonym:

Target: NMDAR, iGluR

Target: ERK, TRP/TRPV Channel, NMDAR, iGluR

NMDAR antagonist 1

T5522

Synonym:

Target: Others, iGluR

(Rac)-NMDAR antagonist 1

T62126

Synonym:

Target:

GluN2B-NMDAR antagonist-1

Synonym: D-APV,D-2-Amino-5-phosphonovaleric acid

Target: NMDAR, iGluR

MDL-29951

T1897

Synonym:

Target: NMDAR, iGluR

Dizocilpine

T6259

Synonym: MK-801

Target: NMDAR, iGluR

Eliprodil

T1751

Synonym: SL-820715

Target: NMDAR, iGluR

カタログ番号	製品名	別名	ターゲット
T6608	NMDA	N-Methyl-D-aspartic acid	Endogenous Metabolite , NMDAR , iGluR
	N-Methyl-D-aspartic acid is an amino acid that, as the D-isomer, is the defining agonist for the NMDA (N-Methyl-D-aspartic acid) receptor subtype of glutamate receptors.		Endogenous Metabolite , NMDAR , iGluR
T1186	Ifenprodil Tartrate		Potassium Channel , NMDAR , iGluR
	Ifenprodil is a selective NMDA receptor (glutamate) antagonist.		Potassium Channel , NMDAR , iGluR
T3377	L-Phenylalanine	(S)-2-Amino-3-phenylpropionic acid,phenylalanine,3-Phenyl-L-alanine	Calcium Channel , Endogenous Metabolite , iGluR
	L-Phenylalanine (3-Phenyl-L-alanine) is an essential amino acid and the precursor of the amino acid tyrosine, acts as an antagonist at α2δ calcium channels.		Calcium Channel , Endogenous Metabolite , iGluR
T2808	Bilobalide	(-)-Bilobalide	Apoptosis , Endogenous Metabolite , Autophagy
	Bilobalide ((-)-Bilobalide), a bioactive from Gingko Biloba, is active on hypoxia-induced alterations.		Apoptosis , Endogenous Metabolite , Autophagy
T1589	D-Cycloserine	RO-1-9213	Others , Antibacterial , Antibiotic , iGluR
	D-Cycloserine (RO-1-9213) is a broad spectrum antibiotic used as a second line agent for treatment of drug resistant tuberculosis, always in combination with other antituberculosis agents.		Others , Antibacterial , Antibiotic , iGluR
T0883	Tramiprosate	Homotaurine,3-Amino-1-propanesulfonic acid,Alzhemed	Beta Amyloid , GABA Receptor
	Tramiprosate (Alzhemed) is an orally active, blood-brain-barrier-crossing, naturally occurring amino acid found in a variety of red seaweeds that binds soluble Aβ and maintains it in a non-protofibrillar form.It is a GAB...		Beta Amyloid , GABA Receptor
T4096	Quinolinic acid	pyridine-2,3-dicarboxylic acid,QUIN	Endogenous Metabolite , NMDAR , iGluR
	Quinolinic acid (QUIN) is an endogenous N-methyl-D-aspartate (NMDA) receptor agonist synthesized from L-tryptophan via the kynurenine pathway.		Endogenous Metabolite , NMDAR , iGluR
T8626	Transtorine	1,4-DIHYDRO-4-OXOQUINOLINE-2-CARBOXYLIC ACID	GluR , NMDAR
	Transtorine (1,4-DIHYDRO-4-OXOQUINOLINE-2-CARBOXYLIC ACID) is a GluR and NMDA inhibitor.		GluR , NMDAR
TQ0027	Transcrocetinate disodium	Disodium trans-crocetinate	NMDAR , iGluR
	Transcrocetinate disodium (Disodium trans-crocetinate), extracted from saffron (Crocus sativus L.), is a high-affinity antagonist of NMDA receptor.		NMDAR , iGluR
T22583	Arcaine sulfate		NMDAR
	Arcaine sulfate is a NMDA antagonist.		NMDAR
T7060	Amantadine	1-Aminoadamantane,1-Adamantanamine,1-Adamantylamine	Others
	Amantadine (1-Aminoadamantane) is an antiviral, is a weak antagonist of the NMDA-type glutamate receptor, increases dopamine release, and blocks dopamine reuptake.		Others
T4893	Spermidine	N-(3-Aminopropyl)-1,4-diaminobutane,N-(4-Aminobutyl)-1,3-diaminopropane	Endogenous Metabolite
	Spermidine (N-(3-Aminopropyl)-1,4-diaminobutane) inhibits NOS1 (nNOS). Spermidine binds and precipitates DNA and may be used for purification of DNA binding proteins. Spermidine activates PNK (polynucleotide kinase T4). ...		Endogenous Metabolite
T10191L	7-Chlorokynurenic acid	7-chloro-4-hydroxy-2-carboxyquinoline,7-CKA	GluR , NMDAR
	7-Chlorokynurenic acid (7-chloro-4-hydroxy-2-carboxyquinoline) is an effecitve and selective antagonist of NMDA receptor with IC50 of 0.56 μM for the glycine B coagonist site. 7-Chlorokynurenic acid inhibits the reuptake...		GluR , NMDAR
T4752	1-Aminocyclopropane-1-carboxylic acid	1-Aminocyclopropanecarboxylic acid,1-Amino-1-carboxycyclopropane,ACC	Endogenous Metabolite , NMDAR
	1-Aminocyclopropane-1-carboxylic acid (ACC) is an intermediate in the synthesis of ethylene, the plant hormone responsible for biological processes ranging from seed germination to organ senescence. It is a small molecul...		Endogenous Metabolite , NMDAR
T4885	(-)-Aspartic acid	(R)-Aspartic acid,Asp,D-(-)-Aspartic acid,Aminosuccinic acid,asparagic acid,L-Homoproline,D-Aspartic acid	Endogenous Metabolite , NMDAR , iGluR
	(-)-Aspartic acid (L-Homoproline) is an endogenous amino acid existing in invertebrates and vertebrates. It can regulate testosterone synthesis and is an agonist of NMDA receptor.		Endogenous Metabolite , NMDAR , iGluR
T60237	L-Cysteine S-sulfate	S-Sulfo-L-cysteine	NMDAR
	L-Cysteine S-sulfate (S-Sulfo-L-cysteine) is an effective N-methyl-d-aspartate (NMDA) glutamatergic receptors agonist. L-Cysteine S-sulfate is the substrate for cystine lyase [1].		NMDAR
TQ0279	Ibotenic acid	(+/-)-Ibotenic acid,DL-Ibotenic acid,Ibotenate,(RS)-Ibotenic acid	NMDAR
	Ibotenic acid (RS-42358-197) has agonist activity at both the NMDA and trans-ACPD or metabotropic quisqualate receptors.		NMDAR
T12536	Pregnenolone monosulfate	3β-Hydroxy-5-pregnen-20-one monosulfate	NMDAR
	Pregnenolone monosulfate (3β-Hydroxy-5-pregnen-20-one monosulfate) is a potent nootropic steroid that positively regulates NMDA recordings, and can be used in studies of neuroticism and depression.		NMDAR
T19882	Bryonolic acid	UNII-J7YR6A878I,20-epi-Bryonolic acid	Apoptosis , Antioxidant , Calcium Channel
	Bryonolic acid (20-epi-Bryonolic acid), a triterpenoid extracted from Sandoricum indicum, possesses immunomodulatory, anti-inflammatory, antioxidant and anticancer activities and protects PC12 cells from NMDA-induced apo...		Apoptosis , Antioxidant , Calcium Channel
T65135	Kynurenic acid	Fibrostop 2,Quinurenic acid	GPR , GluR , NMDAR
	Kynurenic acid (Quinurenic acid) is an endogenous tryptophan active metabolite, a triple antagonist of NMDA, glutamate, α7 nicotinic acetylcholine receptor, and an agonist of GPR35/CXCR8 with neuroprotective and anticonv...		GPR , GluR , NMDAR
T5080	Spermidine trihydrochloride	Spermidine hydrochloride,4-Azaoctamethylenediamine trihydrochloride	NMDAR , Autophagy
	Spermidine trihydrochloride (4-Azaoctamethylenediamine trihydrochloride), a natural polyamine, is a novel autophagy inducer and negatively modulates N-methyl-d-aspartate (NMDA).		NMDAR , Autophagy
T10086	24-Hydroxycholesterol	Cholest-5-ene-3beta,24-diol	Liver X Receptor , NMDAR
	24-Hydroxycholesterol (Cholest-5-ene-3beta,24-diol) is an oxysterol compound that is an activator of the n-methyl-d-aspartate receptor (NMDA) and the transcription factor LXR, which has been used in the study of cardioge...		Liver X Receptor , NMDAR
T8394	D-Serine	(R)-Serine	Endogenous Metabolite , NMDAR , iGluR
	D-Serine ((R)-Serine) is an endogenous amino acid,is a potent co-agonist at the NMDA glutamate receptor.		Endogenous Metabolite , NMDAR , iGluR
T6S0659	Rhynchophylline	Rhynchophyllin,Rhyncophylline,Mitrinermine,Mitrinermin	Calcium Channel , NF-κB
	1. Rhynchophylline (Mitrinermine) can protect against ischemic damage, probably via regulating the Akt/mTOR pathway. 2. Rhynchophylline can protect against glutamate-induced neuronal death, can inhibit MA impairment in c...		Calcium Channel , NF-κB
T4S0171	Transcrocetin	trans-Crocetin,8,8'-Diapocarotenedioic Acid,Crocetin	Others , Endogenous Metabolite , iGluR
	Transcrocetin (8,8'-Diapocarotenedioic Acid) is a singlet oxygen quencher.		Others , Endogenous Metabolite , iGluR
T6S1418	Praeruptorin C		Antioxidant , Calcium Channel
	1. Praeruptorin C has been widely used as an antioxidant and a calcium antagonist to treat diseases. 2. Praeruptorin C partially protects cortical neurons by inhibiting the expression of GluN2B-containing NMDA receptors ...		Antioxidant , Calcium Channel
T13854	Quininic acid		NMDAR
	Quinic acid is an organic acid extracted from the bark of Eucalyptus, Cinchona and other plants in the Asteraceae family.		NMDAR
T2768	Saikosaponin A		NF-κB , Antibacterial , Liver X Receptor
	Saikosaponin A has a variety of pharmacological benefits, including antiepileptic, anti-osteoporosis, antioxidant, anti-in ammatory, immunomodulatory, and anti-bacterial activities. It can effectively attenuate neuropath...		NF-κB , Antibacterial , Liver X Receptor
T4705	Aminoadipic acid	DL-2-Aminoadipic acid	Others , Endogenous Metabolite
	Aminoadipic acid (DL-2-Aminoadipic acid) (2-aminoadipate) is a metabolite in the principal biochemical pathway of lysine. It is an intermediate in the metabolism (i.e. breakdown or degradation) of lysine and saccharopine...		Others , Endogenous Metabolite
T3911	Pulchinenoside A	Anemoside A3	Others
	Pulchinenoside A (Anemoside A3) is an attractive candidate for further development as a cognitive enhancer capable of alleviating memory dysfunctions associated with aging and neurodegenerative diseases.		Others
T6975	Sarcosine	Sarcosinic acid,Methylaminoacetic acid,Sarcosin,Methylglycine,N-Methylaminoacetic acid,N-methylglycine	Others , GlyT , Endogenous Metabolite
	Sarcosine (Methylglycine) is a competitive inhibitor of the type I glycine transporter (GlyT1) and an N-methyl-D-aspartate receptor (NMDAR) co-agonist.		Others , GlyT , Endogenous Metabolite
T2O2728	Glycine	2-Aminoacetic acid,Glycolixir,Aminoacetic acid,Glycosthene,Glycocoll	MT Receptor , Endogenous Metabolite , iGluR
	glycine (2-Aminoacetic acid) is a non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also a fast inhibitory neurotransmitter.		MT Receptor , Endogenous Metabolite , iGluR
T3S2259	Methyl eugenol	4-allylveratrole,eugenyl methyl ether,O-methyleugenol,Eugenol Methyl ether	GABA Receptor
	1. Methyl eugenol (4-allylveratrole) is a natural constituent of the essential oils of a number of plants widely used in foodstuffs as flavouring agents, in view of the carcinogenic potential of ME, the need to check its...		GABA Receptor
T2S2264	Linalool	Linalol,(±)-Linalool,Phantol	Apoptosis , IL Receptor , TNF , Endogenous Metabolite , iGluR
	1. Linalool (Linalol), a natural compound of the essential oils, has been shown to have antinociceptive, antimicrobial, and anti-inflammatory properties. 2. Linalool was protected against LPS/GalN-induced liver injury th...
T75890	Conantokin G TFA
	Conantokin G TFA, a 17-amino-acid peptide, serves as a potent, selective, and competitive antagonist of N-Methyl-D-Aspartate (NMDA) receptors, effectively inhibiting NMDA-evoked currents in murine cortical neurons at an ...
T75267	Crocetin meglumine
	Crocetin (Transcrocetin) meglumine, sourced from Crocus sativus L. (saffron), functions as a high-affinity antagonist of the NMDA receptor.
TN2641	15-Methoxypinusolidic acid		ERK , IL Receptor , p38 MAPK , Calcium Channel , NOS , NF-κB , COX , JNK , NMDAR , PPAR
	15-Methoxypinusolidic acid has anti-inflammatory effects, it inhibits LPS-induced iNOS expression and NO production, independent on MAPK and NF-kappaB. 15-Methoxypinusolidic acid suppresses adipocyte differentiation thro...

天然物製品

NMDA

T6608

Synonym: N-Methyl-D-aspartic acid

Target: Endogenous Metabolite, NMDAR, iGluR

Ifenprodil Tartrate

T1186

Synonym:

Target: Potassium Channel, NMDAR, iGluR

L-Phenylalanine

T3377

Synonym: (S)-2-Amino-3-phenylpropionic acid,phenylalanine,3-Phenyl-L-alanine

Target: Calcium Channel, Endogenous Metabolite, iGluR

Bilobalide

T2808

Synonym: (-)-Bilobalide

Target: Apoptosis, Endogenous Metabolite, Autophagy

D-Cycloserine

T1589

Synonym: RO-1-9213

Target: Others, Antibacterial, Antibiotic, iGluR

Tramiprosate

T0883

Synonym: Homotaurine,3-Amino-1-propanesulfonic acid,Alzhemed

Target: Beta Amyloid, GABA Receptor

Quinolinic acid

T4096

Synonym: pyridine-2,3-dicarboxylic acid,QUIN

Target: Endogenous Metabolite, NMDAR, iGluR

Transtorine

T8626

Synonym: 1,4-DIHYDRO-4-OXOQUINOLINE-2-CARBOXYLIC ACID

Target: GluR, NMDAR

Transcrocetinate disodium

TQ0027

Synonym: Disodium trans-crocetinate

Target: NMDAR, iGluR

Synonym: 1-Aminoadamantane,1-Adamantanamine,1-Adamantylamine

Target: Others

Spermidine

T4893

Synonym: N-(3-Aminopropyl)-1,4-diaminobutane,N-(4-Aminobutyl)-1,3-diaminopropane

Target: Endogenous Metabolite

7-Chlorokynurenic acid

T10191L

Synonym: 7-chloro-4-hydroxy-2-carboxyquinoline,7-CKA

Target: GluR, NMDAR

1-Aminocyclopropane-1-carboxylic acid

T4752

Synonym: 1-Aminocyclopropanecarboxylic acid,1-Amino-1-carboxycyclopropane,ACC

Target: Endogenous Metabolite, NMDAR

(-)-Aspartic acid

T4885

Synonym: (R)-Aspartic acid,Asp,D-(-)-Aspartic acid,Aminosuccinic acid,asparagic acid,L-Homoproline,D-Aspartic acid

Target: Endogenous Metabolite, NMDAR, iGluR

L-Cysteine S-sulfate

T60237

Synonym: S-Sulfo-L-cysteine

Target: NMDAR

Ibotenic acid

TQ0279

Synonym: (+/-)-Ibotenic acid,DL-Ibotenic acid,Ibotenate,(RS)-Ibotenic acid

Target: NMDAR

Pregnenolone monosulfate

T12536

Synonym: 3β-Hydroxy-5-pregnen-20-one monosulfate

Target: NMDAR

Bryonolic acid

T19882

Synonym: UNII-J7YR6A878I,20-epi-Bryonolic acid

Target: Apoptosis, Antioxidant, Calcium Channel

Kynurenic acid

T65135

Synonym: Fibrostop 2,Quinurenic acid

Target: GPR, GluR, NMDAR

Spermidine trihydrochloride

T5080

Synonym: Spermidine hydrochloride,4-Azaoctamethylenediamine trihydrochloride

Target: NMDAR, Autophagy

24-Hydroxycholesterol

T10086

Synonym: Cholest-5-ene-3beta,24-diol

Target: Liver X Receptor, NMDAR

D-Serine

T8394

Synonym: (R)-Serine

Target: Endogenous Metabolite, NMDAR, iGluR

Rhynchophylline

T6S0659

Synonym: Rhynchophyllin,Rhyncophylline,Mitrinermine,Mitrinermin

Target: Calcium Channel, NF-κB

Transcrocetin

T4S0171

Synonym: trans-Crocetin,8,8'-Diapocarotenedioic Acid,Crocetin

Target: Others, Endogenous Metabolite, iGluR

Praeruptorin C

T6S1418

Synonym:

Target: Antioxidant, Calcium Channel

Target: NF-κB, Antibacterial, Liver X Receptor

Aminoadipic acid

T4705

Synonym: DL-2-Aminoadipic acid

Target: Others, Endogenous Metabolite

Pulchinenoside A

T3911

Synonym: Anemoside A3

Target: Others

Sarcosine

T6975

Synonym: Sarcosinic acid,Methylaminoacetic acid,Sarcosin,Methylglycine,N-Methylaminoacetic acid,N-methylglycine

Target: Others, GlyT, Endogenous Metabolite

glycine

T2O2728

Synonym: 2-Aminoacetic acid,Glycolixir,Aminoacetic acid,Glycosthene,Glycocoll

Target: MT Receptor, Endogenous Metabolite, iGluR

Methyl eugenol

T3S2259

Synonym: 4-allylveratrole,eugenyl methyl ether,O-methyleugenol,Eugenol Methyl ether

Target: GABA Receptor

Linalool

T2S2264

Synonym: Linalol,(±)-Linalool,Phantol

Target: Apoptosis, IL Receptor, TNF, Endogenous Metabolite, iGluR

15-Methoxypinusolidic acid

TN2641

Synonym:

Target: ERK, IL Receptor, p38 MAPK, Calcium Channel, NOS, NF-κB, COX, JNK, NMDAR, PPAR

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPH-01595	KMO Protein, Human, Recombinant (His)	Human	E. coli
	Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA r...
TMPH-02278	PTPN5 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	May regulate the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors. PTPN5 Protein, Human, Recombinant (His & SUMO) i...
TMPJ-00652	PSD-95 Protein, Rat, Recombinant (His)	Rat	E. coli
	Disks large homolog 4(DLG4) is a cell membrane protein and it is a member of the membrane-associated guanylate kinase (MAGUK) family. The protein contains 1 guanylate kinase-like domain，3 PDZ (DHR) domains and 1 SH3 dom...
TMPH-01394	GRIN1 Protein, Human, Recombinant (His)	Human	E. coli
	Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the ...
TMPJ-00484	SHMT1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Serine Hydroxymethyltransferase Cytosolic (SHMT1) is a member of the SHMT family. SHMT1 is a cytoplasmic protein and exists as a homotetramer. SHMT1 catalyzes the reversible conversion of serine and tetrahydrofolate to g...
TMPY-00134	Netrin G1/NTNG1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	NTNG1 (Netrin G1) is a Protein Coding gene. This gene encodes a preproprotein that is processed into a secreted protein containing eukaryotic growth factor (EGF)-like domains. NTNG1 is broadly expressed in the brain, kid...
TMPY-01692	NETO1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Neuropilin tolloid-like 1 (NETO1), a complement C1r/C1s, Uegf, Bmp1 (CUB) domain-containing transmembrane protein, is a novel component of the NMDAR complex critical for maintaining the abundance of NR2A-containing NMDAR...

KMO Protein, Human, Recombinant (His)

TMPH-01595

Species: Human

Expression System: E. coli

PTPN5 Protein, Human, Recombinant (His & SUMO)

TMPH-02278

Species: Human

Expression System: E. coli

PSD-95 Protein, Rat, Recombinant (His)

TMPJ-00652

Species: Rat

Expression System: E. coli

GRIN1 Protein, Human, Recombinant (His)

TMPH-01394

Species: Human

Expression System: E. coli

SHMT1 Protein, Human, Recombinant (His)

TMPJ-00484

Species: Human

Expression System: HEK293 Cells

Netrin G1/NTNG1 Protein, Human, Recombinant (His)

TMPY-00134

Species: Human

Expression System: HEK293 Cells

NETO1 Protein, Human, Recombinant (His)

TMPY-01692

Species: Human

Expression System: HEK293 Cells

カタログ番号	製品名
L9830	Anti-Parkinson's Disease Compound Library	857 compounds
	A unique collection of 857 compounds with anti-PD activities or acting on main drug targets of PD can be used for HTS and HCS.
L9840	Anti-Alzheimer's Disease Compound Library	986 compounds
	A unique collection of 986 compounds with anti-AD activities or acting on main drug targets of AD can be used for HTS and HCS.

ライブラリー

Anti-Parkinson's Disease Compound Library

L9830

Compounds: 857

Anti-Alzheimer's Disease Compound Library

L9840

Compounds: 986