Powder: -20°C for 3 years | In solvent: -80°C for 1 year
3-Aminobenzamide (PARP-IN-1) is an effective inhibitor of PARP (IC50<50 nM in CHO cells) and a mediator of oxidant-induced myocyte dysfunction during reperfusion.
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100 mg | 在庫あり | ¥ 8,500 | |||
200 mg | 在庫あり | ¥ 11,000 | |||
500 mg | 在庫あり | ¥ 18,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 11,500 |
説明 | 3-Aminobenzamide (PARP-IN-1) is an effective inhibitor of PARP (IC50<50 nM in CHO cells) and a mediator of oxidant-induced myocyte dysfunction during reperfusion. |
ターゲット&IC50 | PARP:<50 nM |
In vitro | INO-1001 (>1 μM) leads to more than 95% inhibition of PARP activity without significant cellular toxicity. In addition, INO-1001 significantly sensitizes CHO cells by blocking most of the DNA repair occurring between radiation fractions. [1] Inhibition of PARP activity by INO-1001 significantly improves endothelial function by enhancing the acetylcholine-induced, endothelium-dependent, nitric oxide mediated vasorelaxation after exposure with 400 μM Water2. [2] |
In vivo | In a db/db (Leprdb/db) mouse model, INO-1001 ameliorates diabetes-induced albumin excretion and mesangial expansion, and also decreases diabetes-induced podocyte depletion. [3] Treatment with INO-1001 (1.6 mg/kg via intracerebral injection) prevents NAD+ depletion and improves water maze performance after controlled cortical impact (CCI) in mice. [4] |
キナーゼ試験 | PARP activity is measured with a PARP Activity Assay Kit. This method measures relative PARP activity by determining the level of incorporation of?3H-NAD into trichloroacetic acid (TCA) precipitable material in the presence of sheared genomic DNA, which activates PARP. The reaction mixture is added directly to washed cultures in 12-well culture plates and the reaction is allowed to proceed for 60 minutes at 37°C before the cells are removed mechanically, transferred to a microcentrifuge tube, and precipitated with ice-cold 5% TCA. |
別名 | 3-AB, INO1001, INO-1001, 3-ABA, PARP-IN-1, INO 1001 |
分子量 | 136.15 |
分子式 | C7H8N2O |
CAS No. | 3544-24-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 26 mg/mL (191 mM)
DMSO: 55 mg/mL (403.97 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. 詳細
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3-Aminobenzamide 3544-24-9 Chromatin/Epigenetic DNA Damage/DNA Repair PARP 3-AB inhibit INO1001 3Aminobenzamide poly ADP ribose polymerase Inhibitor INO-1001 3-ABA PARP-IN-1 INO 1001 3 Aminobenzamide inhibitor