Powder: -20°C for 3 years | In solvent: -80°C for 1 year
9-amino-CPT (Aminocamptothecin) is an inhibitor of topoisomerase I with potent anticancer activity.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 8,000 | |||
2 mg | 在庫あり | ¥ 11,000 | |||
5 mg | 在庫あり | ¥ 21,500 | |||
10 mg | 在庫あり | ¥ 34,000 | |||
25 mg | 在庫あり | ¥ 60,500 | |||
50 mg | 在庫あり | ¥ 90,500 | |||
100 mg | 在庫あり | ¥ 132,500 |
説明 | 9-amino-CPT (Aminocamptothecin) is an inhibitor of topoisomerase I with potent anticancer activity. |
In vitro | 9-Aminocamptothecin inhibits PC-3, PC-3M, DU145, and LNCaP cells with IC50 values of 34.1, 10, 6.5, and 8.9 nM, respectively after 96 h of drug exposure [1]. In human bladder (MGH-U1), breast (MCF-7), and colon (HT-29) cancer cell lines, 9-Aminocamptothecin cytotoxicity increases with both higher drug concentrations and longer exposure times. Minimal cell killing is also observed unless 9-Aminocamptothecin concentrations exceed a threshold of 2.7 nM [2]. |
In vivo | 9-Aminocamptothecin inhibits tumor growth at the lowest oral dose (0.35 mg/kg/day), whereas higher oral doses (0.75 and 1 mg/kg/day) and s.c. administration (4 mg/kg/week) causes tumor regression [1]. 9-Aminocamptothecin induces complete remissions in 55 % of SCID mice engrafted with human myeloid leukemia. The oral and intravenous routes are equally effective [3]. |
植物由来 |
別名 | Aminocamptothecin, 9-amino-2(S)-camptothecin, 9-Aminocamptothecin |
分子量 | 363.37 |
分子式 | C20H17N3O4 |
CAS No. | 91421-43-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 3.33 mg/mL (9.16 mM)
You can also refer to dose conversion for different animals. 詳細
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9-amino-CPT 91421-43-1 DNA Damage/DNA Repair Topoisomerase Inhibitor 9 amino CPT inhibit 9aminoCPT Aminocamptothecin 9-amino-2(S)-camptothecin 9-amino-2camptothecin 9-Aminocamptothecin inhibitor