Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AAL-993 is a potent VEGFR inhibitor with IC50s of 130 nM, 23 nM and 18 nM for VEGFR1, VEGFR2 and VEGFR3, respectively. AAL993 has a weak inhibitory effect on other tyrosine kinases. AAL993 also shows potent antiangiogenic and antitumor activities.
説明 | AAL-993 is a potent VEGFR inhibitor with IC50s of 130 nM, 23 nM and 18 nM for VEGFR1, VEGFR2 and VEGFR3, respectively. AAL993 has a weak inhibitory effect on other tyrosine kinases. AAL993 also shows potent antiangiogenic and antitumor activities. |
ターゲット&IC50 | VEGFR1:130 nM, VEGFR3:18 nM, VEGFR2:23 nM |
In vitro | AAL993 suppressed HIF-1α expression through the inhibition of ERK without affecting Akt phosphorylation[1]. |
In vivo | AAL993 (24-100 mg/kg; p.o.) inhibited both the growth of the primary tumor as well as the formation of spontaneous peripheral metastases in B16 melanoma xenograft model[2]. AAL993 potently inhibited VEGF-induced angiogenesis with an ED50 value of 7 mg/kg in an implant model[2]. |
分子量 | 371.36 |
分子式 | C20H16F3N3O |
CAS No. | 269390-77-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (148.1 mM)
You can also refer to dose conversion for different animals. 詳細
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AAL-993 269390-77-4 Angiogenesis Tyrosine Kinase/Adaptors VEGFR antiangiogenic antitumor properties VEGFR1 AAL993 VEGFR2 orally active AAL 993 VEGFR3 Inhibitor VEGFR inhibitor Vascular endothelial growth factor receptor inhibit inhibitor