Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ABT-639 is a potent and selective T-type calcium channel blocker.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
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1 mg | 在庫あり | ¥ 10,000 | |||
2 mg | 在庫あり | ¥ 15,000 | |||
5 mg | 在庫あり | ¥ 22,500 | |||
10 mg | 在庫あり | ¥ 41,000 | |||
25 mg | 在庫あり | ¥ 81,500 | |||
50 mg | 在庫あり | ¥ 131,500 | |||
100 mg | 在庫あり | ¥ 189,000 | |||
500 mg | 在庫あり | ¥ 388,000 |
説明 | ABT-639 is a potent and selective T-type calcium channel blocker. |
In vitro | ABT-639 is significantly less active at other Ca2+ channels (e.g. Cav1.2 and Cav2.2) (IC50 > 30 μM). ABT-639 has high oral bioavailability (%F = 73), low protein binding (88.9%) and a low brain:plasma ratio (0.05:1) in rodents. |
In vivo | Following oral administration ABT-639 produces dose-dependent antinociception in a rat model of knee joint pain (ED50 = 2 mg/kg, p.o.). ABT-639 (10-100 mg/kg, p.o.) also increases tactile allodynia thresholds in multiple models of neuropathic pain. The antinociceptive profile of ABT-639 provides novel insights into the role of peripheral T-type (Cav3.2) channels in chronic pain states. |
別名 | ABT 639 |
分子量 | 455.91 |
分子式 | C20H20ClF2N3O3S |
CAS No. | 1235560-28-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (120.64 mM)
You can also refer to dose conversion for different animals. 詳細
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ABT-639 1235560-28-7 Membrane transporter/Ion channel Metabolism Calcium Channel ABT639 Ca channels Ca2+ channels inhibit Inhibitor ABT 639 inhibitor