Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ZSET1446 (ST-101) is a T-type calcium channel activator potentially for the treatment of learning deficits in various types of Alzheimer disease (AD) models.
説明 | ZSET1446 (ST-101) is a T-type calcium channel activator potentially for the treatment of learning deficits in various types of Alzheimer disease (AD) models. |
In vivo | ZSET1446 ameliorated cognitive deficits of SAMP8 after 4, 8, 12, and 16 weeks of treatment in a novel object recognition test.?ZSET1446 also reduced grading scores of SAMP8 after 16 weeks of treatment.?Further, 8-week treatment of ZSET1446 significantly reduced the total number of Aβ-positive granules in the hippocampus.?ZSET1446 shows ameliorating effects on SAMP8 partly due to the suppression of an increase of Aβ-deposition in the hippocampus[1]. |
動物実験 | ZSET1446 was administered in drinking water at estimated doses of 0.002, 0.01, and 0.1 mg/kg per day from the age of 8 months mouse.?The SAMP8 at the age of 8 months showed cognitive impairment in a novel object recognition task compared with young SAMP8 at the age of 8 weeks.?Further, grading scores were gradually increased from 9 to 12 months and Aβ-like immunoreactivity in the hippocampus was increased at the age of 10 months[1]. |
別名 | ZSET-1446, ST-101 |
分子量 | 236.27 |
分子式 | C15H12N2O |
CAS No. | 887603-94-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 29 mg/ml(122.74 mM)
You can also refer to dose conversion for different animals. 詳細
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ZSET1446 887603-94-3 Membrane transporter/Ion channel Metabolism Neuroscience AChR Calcium Channel ST101 Inhibitor ZSET-1446 ST-101 Nicotinic acetylcholine receptors Ca2+ channels inhibit nAChR ST 101 Ca channels ZSET 1446 inhibitor