Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AG-270 is an allosteric and orally active inhibitor of MAT2A.
説明 | AG-270 is an allosteric and orally active inhibitor of MAT2A. |
ターゲット&IC50 | Mat2A:14 nM |
In vitro | AG-270 exhibits an IC50 of 20 nM in HCT116 MTAP-null cell SAM at 72 h[1].AG-270 demonstrates potent reduction in levels of intracellular SAM, as well as MTAP-null–selective antiproliferative activity in the HCT116 MTAP isogenic cell model in vitro[1]. |
分子量 | 489.57 |
分子式 | C30H27N5O2 |
CAS No. | 2201056-66-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 6 mg/mL (12.26 mM)
You can also refer to dose conversion for different animals. 詳細
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AG-270 2201056-66-6 Chromatin/Epigenetic Others Methionine Adenosyltransferase (MAT) inhibit Inhibitor cancer Low AG270 AG 270 solid SAM pancreatic lymphoma tumor toxicity inhibitor