Powder: -20°C for 3 years | In solvent: -80°C for 1 year
APY29 is an allosteric modulator of IRE1α; inhibits IRE1α autophosphorylation (IC50 = 280 nM) and activates IRE1α RNase activity.
説明 | APY29 is an allosteric modulator of IRE1α; inhibits IRE1α autophosphorylation (IC50 = 280 nM) and activates IRE1α RNase activity. |
ターゲット&IC50 | IRE1α:280 nM |
In vitro | APY29 selectively influences IRE1α by divergently modulating its RNase activity and oligomerization state through the same binding site, showing opposing effects on RNase activity. Additionally, APY29 has a dose-dependent, contrasting impact on ER stress-induced activation of the endogenous IRE1α RNase [1]. |
分子量 | 332.36 |
分子式 | C17H16N8 |
CAS No. | 1216665-49-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 33.24 mg/mL (100 mM)
You can also refer to dose conversion for different animals. 詳細
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APY29 1216665-49-4 Cell Cycle/Checkpoint IRE1 APY-29 inhibit Inhibitor Inositol requiring enzyme 1 APY 29 inhibitor