|
T6363 |
4μ8C
|
IRE1 Inhibitor III |
IRE1
|
|
4μ8C (IRE1 Inhibitor III)(IC50=76 nM) is an effective and specific IRE1 Rnase inhibitor. |
|
T15594 |
MKC8866
|
|
IRE1
|
|
MKC8866 is a selective IRE1 RNase inhibitor (IC50: 0.29 μM in human vitro). MKC8866 inhibits IRE1 RNase in breast cancer cells leading to the decreased production of pro-tumorigenic factors and it can inhibit prostate ca... |
|
TQ0101 |
MKC3946
|
|
IRE1
|
|
MKC3946 is an effective and soluble IRE1α inhibitor which triggered modest growth inhibition in multiple myeloma cell lines. |
|
T12071 |
MKC9989
|
|
IRE1
|
|
MKC9989 is an inhibitor of Hydroxy aryl aldehydes (HAA). MKC9989 also inhibits IRE1α with an IC50 of 0.23 to 44 μM. |
|
T3654 |
APY29
|
|
IRE1
|
|
APY29 is an allosteric modulator of IRE1α; inhibits IRE1α autophosphorylation (IC50 = 280 nM) and activates IRE1α RNase activity. |
|
TQ0076 |
KIRA6
|
|
IRE1
|
|
KIRA6 is an effective inhibitor of IRE1α RNase kinase (IC50: 0.6 μM). It can trigger an apoptotic response. |
|
T11488 |
GSK2850163
|
|
IRE1
|
|
|
|
T6681 |
STF-083010
|
STF083010 |
IRE1
|
|
STF-083010 is a selective inhibitor of the IRE1α endonuclease. |
|
T11762L |
Kira8
|
AMG-18 |
IRE1
|
|
Kira8 (AMG-18) is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity (IC50: 5.9 nM). |
|
T9349 |
IXA4
|
|
IRE1
|
|
IXA4 is a highly selective, nontoxic activator of IRE1/XBP1s and reduces APP secretion by activating IRE1. IXA4-stimulated IRE1 activation also enhanced pancreatic function. |
|
T9564 |
IRE1α kinase-IN-1
|
|
IRE1
|
|
IRE1α kinase-IN-1 is a highly selective IRE1α (ERN1) inhibitor, with an IC50 of 77 nM. It displays 100-fold selectivity for IRE1α over the IRE1β isoform. It inhibits ER stress-induced IRE1α oligomerization and autophosph... |
|
T0374L |
Sunitinib
|
SU 11248 |
Apoptosis
,
Mitophagy
,
VEGFR
,
FLT
,
IRE1
,
PDGFR
,
c-Kit
,
Autophagy
|
|
Sunitinib (SU 11248) is a multi-targeted receptor tyrosine kinase (RTK) inhibitor that inhibits VEGFR2 and PDGFRβ (IC50=80/2 nM). Sunitinib has antitumor activity and can be used for the treatment of kidney cancer and ga... |
|
T0374 |
Sunitinib Malate
|
Sutent,SU 11248 (Malate),SU 11248,Sunitinib |
Apoptosis
,
Mitophagy
,
VEGFR
,
FLT
,
IRE1
,
PDGFR
,
c-Kit
,
Autophagy
|
|
Sunitinib Malate (Sunitinib) is an indolinone-based tyrosine kinase inhibitor. It blocks the tyrosine kinase activities of VEGFR2, PDGFRβ (IC50: 80/2 nM), and c-kit. |
|
T79062 |
IRE1α kinase-IN-8
|
|
IRE1
|
|
IRE1α kinase-IN-8, a benzoheterocyclecarboxaldehyde derivative, serves as a potent inhibitor of IRE-1α. This compound is utilized in research pertaining to diseases linked to the unfolded protein response and regulated I... |
|
T79063 |
IRE1α kinase-IN-9
|
|
IRE1
|
|
IRE1α kinase-IN-9 (compound 2) is a potent inhibitor of IRE-1α, demonstrating an average IC50 value of less than 0.1 μM. It is suitable for research into diseases linked to the unfolded protein response or regulated IRE1... |
|
T63734 |
IRE1α kinase-IN-5
|
|
|
|
IRE1α kinase-IN-5 (compound 7) is a potent inhibitor of IRE1α (Ki: 98 nM) and is an ATP-competitive ligand for IRE1α. |
|
T38841 |
IRE1α kinase-IN-2
|
IRE1α kinase-IN-2 |
|
|
IRE1α kinase-IN-2 is a highly potent inhibitor of IRE1α kinase, demonstrating an EC50 of 0.82 μM. It effectively impedes IRE1α kinase autophosphorylation with an IC50 of 3.12 μM. Additionally, IRE1α kinase-IN-2 effective... |
|
T40336 |
IRE1α kinase-IN-6
|
IRE1α kinase-IN-6 |
|
|
IRE1α kinase-IN-6 is a potent IRE1α inhibitor with an IC 50 value of 4.4 nM. |
|
T72641 |
IRE1α kinase-IN-7
|
|
|
|
IRE1α kinase-IN-7 is a chemical compound functioning as an inhibitor of IRE1α kinase, primarily utilized in the research of diseases related to endoplasmic reticulum stress. |
|
T63511 |
IRE1α kinase-IN-4
|
|
|
|
IRE1α kinase-IN-4 (compound 6) is a potent inhibitor of IRE1α, exhibiting a Ki value of 140 nM. It acts as an ATP-competitive ligand for IRE1α [1]. |
|
T63839 |
IRE1α kinase-IN-3
|
|
|
|
IRE1α kinase-IN-3 is a potent, ATP-competitive inhibitor of IRE1α (Ki: 480 nM). |
|
T62568 |
IXA6
|
|
IRE1
|
|
IXA6 is a novel IRE1/XBP1s agonist with potential vasoprotective activity that activates IRE1-XBP1s signaling and XBP1s transcriptional response, which can be used to study neurodegenerative diseases such as Parkinson's ... |
|
T14847 |
B I09
|
|
Others
,
IRE1
|
|
B I09, an IRE-1 RNase inhibitor with an IC50 of 1230 nM, inhibits splicing of XBP1 mRNA in human WaC3 cells and expression of xbp-1 in LPS-stimulated B cells. B I09 can be used to simulate the defects of XBP-1 in CLL cel... |
|
T64049 |
KIRA9
|
|
|
|
KIRA9 is a potent inhibitor of IRE1 with an IC50 value of 4.8 μM for INS-1 cells. KIRA9 completely binds the ATP binding site of IRE1 and blocks endoplasmic reticulum (ER) localised mRNA decay and apoptosis. |
|
T69410 |
CB5305630
|
|
|
|
CB5305630 is an IRE1 inhibitor. |
