Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Adefovir dipivoxil (GS 0840) is a dipivoxil formulation of adefovir, a nucleoside reverse transcriptase inhibitor analog of adenosine with activity against hepatitis B virus (HBV), herpes virus, and human immunodeficiency virus (HIV).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
25 mg | 在庫あり | ¥ 7,500 | |||
50 mg | 在庫あり | ¥ 10,500 | |||
100 mg | 在庫あり | ¥ 14,000 | |||
200 mg | 在庫あり | ¥ 22,500 | |||
500 mg | 在庫あり | ¥ 53,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 11,000 |
説明 | Adefovir dipivoxil (GS 0840) is a dipivoxil formulation of adefovir, a nucleoside reverse transcriptase inhibitor analog of adenosine with activity against hepatitis B virus (HBV), herpes virus, and human immunodeficiency virus (HIV). |
In vitro | Compared to the placebo control group with 5.3 log10 GE/mL, Adefovir Dipivoxil significantly reduced serum HBV DNA levels in transgenic mice to 3.5 log10 genome equivalents (GE) per mL, indicating a marked suppression of the hepatitis B virus. In the liver, Adefovir Dipivoxil's antiviral activity peaked on day 10, achieving hepatitis B virus inhibition endpoints at a dose of 1.0 mg/kg/day. Furthermore, Adefovir Dipivoxil decreased liver HBV DNA to <0.1 picograms of hepatitis B virus per total DNA (picograms/mg) in each transgenic mouse. |
In vivo | In the duck HBV (DHBV) model, Adefovir dipivoxil, when used in combination with other nucleoside analogs (Lamivudine, Entecavir, Emtricitabine [FTC], and Telbivudine [L-dT]), exhibits superior antiviral effects compared to monotherapy. Adefovir dipivoxil effectively inhibits viral CCC DNA both in vitro and in vivo within the same model. Notably, Adefovir retains significant anti-HBV activity soon after being introduced to cells. Its use in conjunction with Lamivudine, FTC, or L-dT demonstrates cumulative effects, while synergy is observed when combined with Entecavir or Tenofovir. Additionally, Adefovir dipivoxil suppresses the activity of the polymerase by inhibiting the transcription of the pre-genomic RNA. The dosage of Adefovir dipivoxil is correlated with its ability to suppress the release of the virus in culture supernatants and the synthesis of viral DNA within cells. |
別名 | Hepsera, GS 0840, Preveon |
分子量 | 501.47 |
分子式 | C20H32N5O8P |
CAS No. | 142340-99-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 93 mg/mL (185.5 mM)
Ethanol: 93 mg/mL (185.5 mM)
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Adefovir dipivoxil 142340-99-6 Microbiology/Virology Others Reverse Transcriptase HBV inhibit Endogenous Metabolite infection GS0840 GS-0840 Hepsera Hepatitis B virus analogue nucleotide prodrug GS 0840 oral Inhibitor Preveon inhibitor