Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Anandamide ((5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide), an immune modulator, acts via not only cannabinoid receptors (CB1 and CB2) but also other targets (e.g., GPR18/GPR55) in the central nervous system.
説明 | Anandamide ((5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide), an immune modulator, acts via not only cannabinoid receptors (CB1 and CB2) but also other targets (e.g., GPR18/GPR55) in the central nervous system. |
In vitro | Anandamide, acting via CB2 receptors, alleviates lipopolysaccharide (LPS)-induced neuroinflammation in rat primary microglial cultures. Endocannabinoids, especially Anandamide (AEA), can activate numerous other receptors like PPARS, TRPV1, and GPR18/GPR55 [1]. |
In vivo | Anandamide is an endocannabinoid binding both CB1R and CB2R. To evaluate the impact of CBR activation on whole-body glucose homeostasis, glucose tolerance is assessed after a single intraperitoneal Anandamide injection (10 mg/kg). The increase in glycemia in response to glucose ingestion is considerably smaller in mice treated with Anandamide compared with control. It is associated with an improvement of glucose tolerance as illustrated by the AUC0-2h calculations[2]. |
別名 | (5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide |
分子量 | 347.53 |
分子式 | C22H37NO2 |
CAS No. | 94421-68-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 10 mg/mL (28.77 mM)
DMSO: 55 mg/mL (158.26 mM)
You can also refer to dose conversion for different animals. 詳細
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Anandamide 94421-68-8 GPCR/G Protein Metabolism Cannabinoid Receptor Endogenous Metabolite Transient receptor potential channels Inhibitor inhibit Alzheimer’s disease Candida albicans anti-fungal anti-adhesive cervical epithelial cells G protein-coupled receptor 55 Streptozotocin (5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide hVSMC N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide HeLa cells GPR55 TRP Channel endocannabinoid Peroxisome proliferator-activated receptors Fungal PPAR Tau Protein inhibitor