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カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T28441 | PPI-1019 | PPI1019,Apan | Beta Amyloid |
PPI-1019 is an APP (β-amyloid A4) inhibitor for the treatment of neurological disorders and the study of Alzheimer's disease (AD). | |||
T10217L | Abarelix | R3827,PPI 149 | GNRH Receptor |
Abarelix (PPI 149) is a potent gonadotrophin-releasing hormone (GnRH) antagonist, which is used for prostate cancer treatment. | |||
T69258 | PPI-2458 | ||
PPI-2458 is a synthetic derivative of fumagillin with antineoplastic and cytotoxic properties. PPI-2458 irreversibly inhibits the enzyme methionine aminopeptidase type 2 (MetAP2), thereby preventing abnormal cell growth ... | |||
T72785 | PRMT5:MEP50 PPI | ||
PRMT5:MEP50 PPI, a pioneering inhibitor of the PRMT5:MEP50 protein-protein interaction (PRMT5:MEP50 PPI), demonstrates anti-tumor and anti-proliferative effects in lung and prostate cancer cells. | |||
T62447 | Paltimatrectinib | PBI-200,PPI-5278 | Trk receptor , Tyrosine Kinases |
Paltimatrectinib (PBI-200) is a potent tyrosine kinase inhibitor with anticancer activity that inhibits myosin-related kinase A (TrkA).Paltimatrectinib is used in the study of bladder, breast and colorectal cancers. | |||
T7387 | Ceftaroline fosamil | TAK-599,PPI0903 | Antibacterial , Antibiotic |
Ceftaroline fosamil (TAK-599) is a cephalosporin, with activity against Gram-positive pathogens. | |||
T79457 | PEX5-PEX14 PPI-IN-1 | ||
PEX5-PEX14 PPI-IN-1 (Compound 8) is a PEX14-PEX5 protein-protein interaction (PPI) inhibitor that disrupts the interaction between PEX5 and TbPEX14 with an inhibitory constant (Ki) of 53 μM. It effectively inhibits the b... | |||
T10217 | Abarelix Acetate (183552-38-7 free base) | PPI 149 Acetate,Abarelix Acetate | Others |
Abarelix (PPI 149; R 3827) Acetate is a potent gonadotrophin-releasing hormone (GnRH) antagonist, used for prostate cancer research. | |||
T81503 | PEX5-PEX14 PPI-IN-2 | ||
Compound 12, also known as PEX5-PEX14 PPI-IN-2, is a PEX14-PEX5 protein-protein interaction (PPI) inhibitor with half-maximal effective concentration (EC50) values of 5 µM in T. b. brucei and 17 µM in HepG2 cells. It is ... | |||
T82758 | CDK9-Cyclin T1 PPI-IN-1 | CDK | |
CDK9-Cyclin T1 PPI-IN-1 (Compound B19) is a selective inhibitor of the CDK9-Cyclin T1 protein-protein interaction (PPI), suppressing cell proliferation in TNBC MDA-MB-231 cells with an IC50 of 0.044 μM and inducing apopt... | |||
T8784 | IGS-1.76 | Others | |
IGS-1.76 exhibits pronounced affinity towards hNCS-1 and effectively modulates the interaction between hNCS-1 and Ric8a. Moreover, IGS-1.76 proficiently inhibits the complex formed by human NCS-1 and Ric8a. | |||
T26859 | BMS-8 | PD-1/PD-L1 | |
BMS-8 is a novel inhibitor of the PD-1/PD-L1 interaction (IC50: 7.2 μM) by binding directly to PD-L1 and inducing the formation of PD-L1 homodimers. | |||
T4647 | M2I-1 | M2I 1 | Others |
M2I-1 a small Mad2 inhibitor-1. the first small molecule inhibitor targeting the binding of Mad2 to Cdc20, an essential proteinprotein interaction (PPI) within the SAC. It can disturbs conformational dynamics of Mad2 cri... | |||
T6889 | MI-136 | Apoptosis , Epigenetic Reader Domain , Androgen Receptor | |
MI-136 inhibits expression of androgen receptor (AR) target genes that DHT induced. | |||
T9039 | HIV-1 Nef-IN-1 | HIV Protease | |
HIV-1 Nef-IN-1 is an inhibitor of HIV-1 Nef protein. It efficiently competes for Nef-SH3Hck interactions(Kd : 6.7 μM). | |||
T9044 | SORT-PGRN interaction inhibitor 1 | Neurotensin Receptor | |
SORT-PGRN interaction inhibitor 1 is a potent sortilin-progranulin interaction inhibitor(IC50 of 2 μM). | |||
T13018 | SU3327 | halicin | JNK |
SU3327 (halicin) is a potent, selective and substrate-competitive inhibitor of JNK(IC50 of 0.7 μM). | |||
T8421 | TED-347 | YAP | |
TED-347 is an irreversible and covalent inhibitor of TEAD4-Yap1 protein-protein interaction(EC50 of 5.9 μM), and inhibits glioblastoma cell viability. | |||
T8216 | T-1101 tosylate | TAI-95 tosylate | Apoptosis , Microtubule Associated |
T-1101 tosylate (TAI-95 tosylate) is an inhibitor of Hec1/Nek2, with antitumor activity. | |||
T6928 | Pantoprazole | SKF96022,BY1023 | Apoptosis , Proton pump , Autophagy |
Pantoprazole (BY1023) is a proton pump inhibitor used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease. | |||
T1651 | Rabeprazole sodium | Dexrabeprazole Sodium,LY307640 sodium,Habeprazole Sodium,Rebeprazole sodium,Aciphex Sodium | Apoptosis , Proton pump |
Rabeprazole sodium (Habeprazole Sodium) is a 4-(3-methoxypropoxy)-3-methylpyridinyl derivative of timoprazole that is used in the therapy of stomach ulcers and Zollinger-Ellison syndrome. The drug inhibits H(+)-K(+)-exch... | |||
T71022 | GI-129471 | ||
GI-129471 is a metalloproteinase inhibitor, specifically blocking TNF-alpha secretion both in vitro and in vivo. | |||
T0161 | Pantoprazole Sodium Hydrate | SKF96022 sodium hydrate,BY1023 (sodium hydrate),SKF96022 (sodium hydrate) | Apoptosis , Potassium Channel , Proton pump , Autophagy |
Pantoprazole Sodium Hydrate (BY1023 (sodium hydrate)) is a proton pump inhibitor drug, used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease. | |||
T6929 | Pantoprazole sodium | Pantecta,SKF96022 sodium,SKF96022 (sodium),BY1023 (sodium),BY-1023 sodium,Pantoloc | Apoptosis , Others , Proton pump , HIF , Autophagy |
Pantoprazole sodium (Pantecta) is the sodium salt form of a substituted benzimidazole with proton pump inhibitor activity. Pantoprazole sodium is a lipophilic, weak base that crosses the parietal cell membrane and enters... | |||
T22135 | PPIase-Parvulin Inhibitor | Others | |
PPIase-Parvulin Inhibitor is a cell-pemeable inhibitor of the Pin1 and Pin4. | |||
T8873 | Bractoppin | Others , DNA/RNA Synthesis | |
Bractoppin is a drug-like inhibitor of phosphopeptide recognition by the human BRCA1 tandem (t)BRCT domain (IC50 = 0.074 μM), which selectively inhibits substrate binding with nanomolar potency in vitro. Structure-activi... | |||
T16421 | P-MPPI hydrochloride | 5-HT Receptor | |
p-MPPI hydrochloride is a selective antagonist of 5-HT1A receptor, and has antidepressant and anxiolytic-like effects. | |||
T22747 | DPPI 1c hydrochloride | Others | |
DPPI 1c hydrochloride is an inhibitor of dipeptidyl peptidase IV (IC50 = 104 nM) that shows selectivity over enzymes with DPP-like activity (IC50 > 30 μM). | |||
T24652 | Poloppin | ||
Poloppin is a protein-protein interactions modulator of the mitotic polo-like kinases that acts by targeting mutant KRAS. It works synergistically with Crizotinib, an inhibitor of the c-MET receptor, against mutant KRAS-... | |||
T37893 | 3-MPPI | ||
3-MPPI was a high-affinity nonselective α1-antagonist. | |||
T9202 | DDO-5936 | HSP | |
DDO-5936 is a potent and specific HSP90-Cdc37 PPI inhibitor. | |||
T20626 | Esomeprazole | Proton pump , Cysteine Protease | |
Esomeprazole is the S-isomer of omeprazole, inhibits the lysosomal cysteine protease legumain to prevent cancer metastasis. Esomeprazole is a proton pump inhibitors (PPI). | |||
T9642 | ZW4864 free base | Wnt/beta-catenin | |
ZW4864 (free base) is an orally active and selective β catenin/B-Cell lymphoma 9 protein protein interaction ( β catenin/BCL9 PPI ) inhibitor. ZW4864 (free base) inhibits β catenin/BCL9 PPI with a K i value of 0.76 μM an... | |||
T60217 | TAS1553 | Others | |
TAS1553 is a highly effective, orally bioavailable protein-protein interaction (PPI) inhibitor with an IC50 value of 0.0396 μM. It effectively hinders DNA replication and diminishes the intracellular dATP pool. Moreover,... | |||
T11666 | IPR-803 | Serine/threonin kinase | |
IPR-803 is an effective inhibitor of the uPAR·uPA protein-protein interaction (PPI) with anti-tumor activity. IPR-803 binds directly to uPAR with a Ki of 0.2 μM. | |||
T60657 | (R)-STU104 | TNF , MAPK | |
(R)-STU104 is a novel TAK1-MKK3 protein-protein interaction (PPI) inhibitor that inhibits TNF-α and suppresses the TAK1/MKK3/p38/MnK1/MK2/elF4E signalling pathway by binding to MKK3 and disrupting TAK1 phosphorylation of... | |||
T6700 | Tenatoprazole | TU-199 | Proton pump |
Tenatoprazole (TU-199), a prodrug of the proton pump inhibitor (PPI) class, can inhibit proton transport (IC50: 3.2 μM). | |||
T10138 | 4-Desmethoxy Omeprazole | Drug Metabolite | |
4-Desmethoxy Omeprazole is the active metabolite of Omeprazole. Omeprazole is a proton pump inhibitor (PPI). Omeprazole shows competitive inhibition of CYP2C19 activity (Ki: 2 to 6 μM). | |||
T22391 | Omeprazole Sodium | P450 , Proton pump , Antibacterial , Autophagy | |
Omeprazole Sodium is a proton pump inhibitor(PPI) and suppresses gastric acid secretion. Omeprazole Sodium is a potent neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor). Omeprazole Sodium shows competitive... | |||
T0757 | Omeprazole | Losec,Prilosec,H 16868,Antra | Proton pump , Phospholipase , Antibacterial , Autophagy |
Omeprazole (Losec) is a proton pump inhibitor (PPI), Omeprazole(Losec) is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor). | |||
T12906 | SI-2 hydrochloride | EPH 116 hydrochloride | Src |
SI-2 hydrochloride (EPH 116 hydrochloride) is a highly promising inhibitor of SRC-3 SMI: SRC-3 (PPI)(IC50 values of 3-20 nM for breast cancer cell death), with acceptable oral availability. | |||
T10221 | Abeprazan hydrochloride | DWP14012 hydrochloride,Fexuprazan hydrochloride | Proton pump |
Abeprazan hydrochloride (Fexuprazan hydrochloride) is an effective reversible potassium-competitive acid blocker with oral activity, inhibiting H+, K+ -atPase by competitive binding to potassium ions without acid activat... | |||
T11096 | DRI-C21045 | NF-κB | |
Dri-c21045 showed concentration-dependent inhibition of NF- B activation and all CD40L induced by B cell proliferation. IC50 was 17.1 M and 4.5 M, respectively.Dri-c21045 is an effective selective inhibitor of CD40-CD40L... | |||
T38050 | CP-609754 | Transferase | |
CP-609754 (LNK-754) is a potent and reversible farnesyltransferase inhibitor with potential anticancer activity.The IC50 for inhibiting farnesylation of recombinant human H-Ras is 0.57 ng/mL and recombinant K-Ras is 46 n... | |||
T35841 | 5-Benzyloxygramine | Dopamine Receptor , 5-HT Receptor | |
5-Benzyloxygramine is a N protein PPI orthosteric stabilizer that exhibits both antiviral and N-NTD protein-stabilizing activities[1]. 5-benzyloxygramine stabilizes the N-NTD dimers through simultaneous hydrophobic inter... | |||
T23693 | AKCI | ||
AKCI is a PPI inhibitor that acts by targeting the AURKC-IκBα interaction. | |||
T27996 | MDK-3298 | Mcl-1 Inhibitor-5,Mcl-1 Inhibitor 5,MDK3298,Mcl-1 Inhibitor5 | |
MDK-3298 is a reversible covalent inhibitor of Mcl-1, a target of protein-protein interaction (PPI). | |||
T40256 | ZW4864 | ||
ZW4864 is a selective inhibitor of the β-catenin/B-Cell Lymphoma 9 protein (β-catenin/BCL9 PPI) interaction, demonstrating oral activity. It inhibits β-catenin/BCL9 PPI with a K_i value of 0.76 μM and an IC_50 value of 0... | |||
T27077 | CPUY192018 Disodium | CPUY-192018,CPUY192018,CPUY192018disodium,CPUY192018 Na2,CPUY192018-disodium | |
CPUY192018 Disodium is a potent inhibitor of the Keap1-Nrf2 PPI. The inhibition of the Keap1-Nrf2 PPI may be beneficial as a treatment for ulcerative colitis. | |||
T8731 | BCL6-IN-7 | ||
BCL6-IN-7 is a potent BCL6 protein-protein interaction(PPI) inhibitor[1]. |
カタログ番号 | 製品名 | 別名 | ターゲット |
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TN1646 | Flemiphilippinin A | Others | |
Flemiphilippin A has antioxidant activity, it shows DPPH radical scavenging activity with effective half maximal concentration (EC50) of 18.36 ug/mL. Flemiphilippinin A (5 ug/mL) exhibits some level of antitumor activity... | |||
TN6340 | Philippin A | ||
Philippin A is a natural product for research related to life sciences. The catalog number is TN6340 and the CAS number is 1848254-99-8. | |||
T21651 | Lansoprazole sodium | Lansoprazole (sodium), AG-1749 sodium | Proton pump , Phospholipase , Antibacterial |
Lansoprazole sodium (Lansoprazole (sodium)) is a proton pump inhibitor (PPI) and a potent inhibitor of gastric acidity which is widely used in the therapy of gastroesophageal reflux and peptic ulcer disease. | |||
TN5171 | Tricetin | Apoptosis , Others , Nrf2 | |
Tricetin is a flavonoid isolated from pomegranate.Tricetin is a potent competitive inhibitor of Keap1-Nrf2 protein-protein interaction (PPI) and protects Parkinson's disease patients from 6-OHDA-induced neurotoxicity by ... | |||
T4721 | β-Nicotinamide mononucleotide | β-NM | Others , Endogenous Metabolite |
β-Nicotinamide mononucleotide (β-NM) is an important intermediate metabolite in the nicotinate and nicotinamide metabolism pathway. Mammals predominantly use nicotinamide rather than nicotinic acid as a precursor for NAD... |
カタログ番号 | 製品名 | Species | Expression System |
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TMPY-05824 | Dengue virus (DENV)(type 3, strain Philippines/H87/1956) E/Envelope Protein (aa 247-675, His) | DENV | HEK293 |
Dengue virus (DENV)(type 3, strain Philippines/H87/1956) E/Envelope Protein (aa 247-675, His) is expressed in HEK293 with His tag. The predicted molecular weight is 48.79 kDa. Accession number: AAA99437.1 | |||
TMPY-04903 | Dengue virus (DENV) (type 3, strain Philippines/H87/1956) NS1 Protein (His) | DENV | HEK293 |
Dengue virus (DENV) (type 3, strain Philippines/H87/1956) NS1 Protein (His) is ecpressed in HEK293 cells. | |||
TMPJ-00971 | PPIC Protein, Human, Recombinant (Trx & His) | Human | E. coli |
Cyclophilin C is an enzyme (EC 5.2.1.8) found in both prokaryotes and eukaryotes that interconverts the cis and trans isomers of peptide bonds with the amino acid proline. Proline has an unusually conformationally restra... | |||
TMPH-00687 | PPIase A Protein, E. coli O6:H1, Recombinant (His & Myc & SUMO) | E. coli | E. coli |
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. | |||
TMPY-05023 | Dengue virus (DENV) (type 4, strain Philippines/H241/1956) NS1 Protein (His) | DENV | HEK293 |
Dengue virus (DENV) (type 4, strain Philippines/H241/1956) NS1 Protein (His) is expressed in HEK293 with His tag. The predicted molecular weight is 42 kDa. Accession number: AAX48017.1 | |||
TMPH-00705 | PPIase A Protein, E. coli, Recombinant (His & SUMO) | E. coli | E. coli |
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. | |||
TMPY-04800 | Dengue virus (DENV) (type 4, strain Philippines/H241/1956) E/Envelope Protein (His) | DENV | Baculovirus-Insect Cells |
Dengue virus (DENV) (type 4, strain Philippines/H241/1956) E/Envelope Protein (His) is expressed in Baculovirus-Insect Cells with His tag. The predicted molecular weight is 44.8 kDa. Accession number: AAX48017.1 | |||
TMPY-06466 | Dengue virus (DENV) (type 3, strain Philippines/H87/1956) E/Envelope Protein (aa 579-678, His) | DENV | Baculovirus-Insect Cells |
Dengue virus (DENV) (type 3, strain Philippines/H87/1956) E/Envelope Protein (aa 579-678, His) is expressed in Baculovirus-Insect Cells with His tag. The predicted molecular weight is 16.48 kDa. Accession number: AAA9943... | |||
TMPY-03413 | PPIL2 Protein, Human, Recombinant (aa 280-457, His) | Human | E. coli |
PPIL2, is an enzyme that belongs to the cyclophilin family. The cyclophilins are peptidylprolyl isomerases and are highly conserved ubiquitous. They play an important role in protein folding, immunosuppression by cyclosp... | |||
TMPJ-01090 | PPID Protein, Human, Recombinant (His) | Human | E. coli |
Peptidyl-Prolyl Cis-Trans Isomerase D (PPID) belongs to the cyclophilin-type PPIase family and PPIase D subfamily. PPID is widely expressed and it contains one PPIase cyclophilin-type domain and three TPR repeats. PPID c... | |||
TMPJ-01389 | PPIE Protein, Human, Recombinant (His) | Human | E. coli |
Peptidyl-prolyl cis-trans isomerase E, also known as Cyclophilin E, Cyclophilin-33, Rotamase E, CYP33, PPIE, is an enzyme which belongs to the cyclophilin-type PPIase family of PPIase E subfamily. PPIE found in all the e... | |||
TMPY-05821 | Dengue virus (DENV) (type 4, strain Philippines/H241/1956) E/Envelope Protein (aa 579-679, His) | DENV | HEK293 |
Dengue virus (DENV) (type 4, strain Philippines/H241/1956) E/Envelope Protein (aa 579-679, His) is expressed in HEK293 with His tag. The predicted molecular weight is 12.41 kDa. Accession number: AAX48017.1 | |||
TMPY-04668 | Influenza A H3N2 (A/Philippines/472/2002) (MDCK) Hemagglutinin/HA1 Protein (His) | H3N2 | HEK293 |
The influenza viral Hemagglutinin (HA) protein is a homotrimer with a receptor binding pocket on the globular head of each monomer.HA has at least 18 different antigens. These subtypes are named H1 through H18.HA has two... | |||
TMPK-00377 | DPPIV/CD26 Protein, Cynomolgus/Rhesus macaque, Recombinant (His) | Cynomolgus,Rhesus macaque | HEK293 |
CD26/dipeptidyl peptidase (DPP)IV is a membrane-bound protein found in many cell types of the body, and a soluble form is present in body fluids. There is longstanding evidence that various primary tumors and also metast... | |||
TMPJ-00676 | PPIH Protein, Human, Recombinant (His) | Human | E. coli |
Peptidyl-Prolyl Cis-Trans Isomerase H (PPIH) belongs to the Cyclophilin-type PPIase family that accelerate the folding of proteins. PPIases can catalyze the cis-trans isomerization of Proline Imidic peptide bonds in olig... | |||
TMPH-03405 | Reston ebolavirus (REBOV) (strain Philippines-96) Nucleoprotein/NP Protein (His & SUMO) | REBOV | E. coli |
Oligomerizes into helical capsid to encapsidate the viral genome, protecting it from nucleases and the cellular innate immune response. VP35 binds to and stabilizes monomeric NP, keeping it soluble. Upon virus replicatio... | |||
TMPY-03285 | PPIL1 Protein, Human, Recombinant (His) | Human | E. coli |
PPIL1 is a member of the cyclophilin family. Cyclophilins are well conserved and ubiquitous. Members of cyclophilin family take a significant part in protein folding, immunosuppression by cyclosporin A, and infection of ... | |||
TMPY-04941 | Influenza A H3N2 (A/Philippines/472/2002) Hemagglutinin/HA Protein (His) | H3N2 | Baculovirus-Insect Cells |
The influenza viral Hemagglutinin (HA) protein is a homotrimer with a receptor binding pocket on the globular head of each monomer.HA has at least 18 different antigens. These subtypes are named H1 through H18.HA has two... | |||
TMPY-03276 | BLBP Protein, Human, Recombinant | Human | E. coli |
BLBP, also known as FABP7, is a brain fatty acid binding protein. Fatty acid binding proteins (FABPs) are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic l... | |||
TMPH-01051 | CILP Protein, Human, Recombinant (His & Myc) | Human | Baculovirus |
Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligan... | |||
TMPH-03236 | Alkaline phosphatase/ALPL Protein, Rat, Recombinant (His & SUMO) | Rat | E. coli |
Alkaline phosphatase that metabolizes various phosphate compounds and plays a key role in skeletal mineralization and adaptive thermogenesis. Has broad substrate specificity and can hydrolyze a considerable variety of co... |
カタログ番号 | 製品名 | ||
---|---|---|---|
L9400 | PPI Inhibitor Library | 485 compounds | |
A unique collection of 485 PPI-related compounds for drug screening; | |||
L9610 | Cyclic Peptide Library | 55 compounds | |
55 species of cyclic peptide molecules for high-throughput and high-content screening; | |||
L9300 | Macrocyclic Compound Library | 210 compounds | |
210 macrocyclic compounds of known activity for high-throughput, high-content screening; |