Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BMS-929075 is an orally active HCV NS5B replicase (HCV NS5B replicase) palm site variant inhibitor with potency, high oral bioavailability and pharmacokinetic parameters.BMS-929075 shows cytotoxicity.
説明 | BMS-929075 is an orally active HCV NS5B replicase (HCV NS5B replicase) palm site variant inhibitor with potency, high oral bioavailability and pharmacokinetic parameters.BMS-929075 shows cytotoxicity. |
ターゲット&IC50 | Huh-7 cells:60 µM(CC50), HepG2 cells:>12.5 µM(CC50) |
In vitro | BMS-929075 (0-60 µM) showed cytotoxicity with CC50 values of 60, >12.5, and >50 µM for Huh-7, HepG2, and primary human hepatocytes, respectively.[1] |
In vivo | BMS-929075 (i.v. 2 mg/kg; orally 6 mg/kg) showed good pharmacokinetic parameters with an oral bioavailability of 48% in rats.[1] |
別名 | BMS 929075, BMS929075 |
分子量 | 538.54 |
分子式 | C31H24F2N4O3 |
CAS No. | 1217338-97-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 27.5 mg/mL (51.06 mM)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
BMS-929075 1217338-97-0 Microbiology/Virology Proteases/Proteasome HCV Protease BMS 929075 BMS929075 Inhibitor inhibitor inhibit