Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Deferiprone (Deferidone) is an Iron Chelator. The mechanism of action of deferiprone is as an Iron Chelating Activity.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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500 mg | 在庫あり | ¥ 10,000 | |||
1 g | 在庫あり | ¥ 11,500 | |||
5 g | 在庫あり | ¥ 13,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 10,500 |
説明 | Deferiprone (Deferidone) is an Iron Chelator. The mechanism of action of deferiprone is as an Iron Chelating Activity. |
In vitro | Administration of 100 mg/kg Deferiprone resulted in a 24% reduction in the average cross-sectional area of the basilar artery in rabbits. When combined with subarachnoid hemorrhage (SAH), Deferiprone also demonstrated variability in the waviness of the internal elastic lamina in rabbits. |
In vivo | At a concentration of 1 mM, Deferiprone causes a significant decrease in complex I-III activity in iron-overloaded cardiomyocytes. It exhibits cytotoxic effects on human tumor cell lines HSC-2, HSC-3, and HL-60, with IC50 values of 13.5 μg/mL, 9.9 μg/mL, and 10.6 μg/mL, respectively. The cytotoxicity of HK1 against HL-60 and HSC-2 cells is reduced in the presence of FeCl3. At 100 μg/mL, Deferiprone induces inter-nucleosomal DNA fragmentation in HL-60 cells, a process inhibited by the addition of FeCl3. Protection of myocytes from doxorubicin-induced lactate dehydrogenase release is observed with 100 μM Deferiprone. It effectively inhibits the transfer of radiolabeled iron from iron-loaded cardiomyocytes and protects or restores mitochondrial respiratory enzyme activity in a xanthine oxidase/hypoxanthine superoxide generating system at a concentration of 0.3 mM. Furthermore, 0.5 mM Deferiprone enhances the clearance of free iron from RBC membranes in a time- and dose-dependent manner. A 3 mM concentration significantly reduces hydroxyl radical production from the iron(III)-adriamycin complex in the xanthine oxidase/hypoxanthine superoxide generating system. |
別名 | Deferidone, CP20 |
分子量 | 139.15 |
分子式 | C7H9NO2 |
CAS No. | 30652-11-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 2.17 mg/mL (15.62 mM), Sonication is recommended.
H2O: 8.33 mg/mL (59.86 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Deferiprone 30652-11-0 Apoptosis Metabolism Microbiology/Virology Others Proteases/Proteasome HCV Protease Ferroptosis UGT Deferidone HCV inhibit Inhibitor Hepatitis C virus CP20 CP 20 CP-20 inhibitor