Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BTZ043 is a DprE1 inhibitor with nanomolar bactericidal activity against Mycobacterium tuberculosis in vitro.
説明 | BTZ043 is a DprE1 inhibitor with nanomolar bactericidal activity against Mycobacterium tuberculosis in vitro. |
In vitro | The inhibition of BTZ-resistant DprE1 followed the trend observed in the MIC measurements, with the C387 g mutant being more resistant to inhibition by PyrBTZ01, PyrBTZ02, and BTZ043 (7- to 9-fold increases in IC50) than the C387S mutant (2.5- to 4-fold increases in IC50). |
In vivo | BTZ-043 was administered at 100 mg/kg (b.i.d., p.o.), and sulfamethoxazole/trimethoprim (SXT), at 100 mg/kg sulfamethoxazole, was used as a positive control. |
分子量 | 431.39 |
分子式 | C17H16F3N3O5S |
CAS No. | 1161233-85-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 15 mg/mL (34.77 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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BTZ043 1161233-85-7 Microbiology/Virology Others Antibacterial Antibiotic DprE1 BTZ 043 Bacterial BTZ-043 tuberculosis inhibit Inhibitor inhibitor