Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AZD1152 is a pro-drug of Barasertib (AZD1152)-hQPA. Which is a highly selective Aurora B inhibitor with IC50 of 0.37 nM in a cell-free assay.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
2 mg | 在庫あり | ¥ 10,000 | |||
5 mg | 在庫あり | ¥ 16,000 | |||
10 mg | 在庫あり | ¥ 27,000 | |||
25 mg | 在庫あり | ¥ 50,500 | |||
50 mg | 在庫あり | ¥ 88,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 20,500 |
ターゲット&IC50 | Aurora B:0.37 nM |
In vivo | Administration of Barasertib (25 mg/kg) alone markedly suppresses the growth of MOLM13 xenografts, confirmed by the observation of necrotic tissue with infiltration of phagocytic cells[1]. Barasertib (25 mg/kg/day) treatment reduces xenograft levels such that they are slightly lower levels than after the first round of treatment, but this is not statistically significant indicating that residual cells might be more resistant to a second cycle of Barasertib[4]. In addition, Barasertib (10-150 mg/kg/day) significantly inhibits the growth of a variety of human solid tumor xenografts, including colon, breast, and lung cancers, in a dose-dependent manner[2]. |
別名 | AZD1152 |
分子量 | 587.54 |
分子式 | C26H31FN7O6P |
CAS No. | 722543-31-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 33 mg/mL (56.17 mM)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Barasertib 722543-31-9 Apoptosis Cell Cycle/Checkpoint Chromatin/Epigenetic Aurora Kinase breast cancer colon Inhibitor AZD 1152 leukemia lung inhibit AZD-1152 AZD1152 inhibitor