Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Bis(maltolato)oxovanadium(IV) (BMOV) is a potent, reversible, competitive and orally active pan-PTP (protein tyrosine phosphatases)inhibitor with insulin-mimicking effects and anti-diabetic properties. BMOV is a potent insulin sensitize. BMOV is shown to improve cardiac dysfunctions in diabetic models. BMOV inhibits HCPTPA, PTP1B, HPTPβ and SHP2 with IC50s of 126 nM, 109 nM, 26 nM and 201 nM, respectivelyr[1][2].
説明 | Bis(maltolato)oxovanadium(IV) (BMOV) is a potent, reversible, competitive and orally active pan-PTP (protein tyrosine phosphatases)inhibitor with insulin-mimicking effects and anti-diabetic properties. BMOV is a potent insulin sensitize. BMOV is shown to improve cardiac dysfunctions in diabetic models. BMOV inhibits HCPTPA, PTP1B, HPTPβ and SHP2 with IC50s of 126 nM, 109 nM, 26 nM and 201 nM, respectivelyr[1][2]. |
ターゲット&IC50 | HCPTPA:126 nM (IC50), PTP1B:109 nM (IC50), HPTPβ:26 nM (IC50), SHP2:201 nM (IC50) |
In vitro | BMOV treatment enhances the phosphorylation of the insulin receptor and of the insulin signalling key intermediate Akt. BMOV treatment also resultes in an increased glucose uptake in C2C12 cells[1]. |
In vivo | BMOV (0.75-3.0 mmol; intraperitoneal injection; twice weekly; for 6 weeks; Male C57BL/6J mice) treatment ameliorates the metabolic phenotype, as evidenced by reduced body weight, improved insulin sensitivity and glucose tolerance. |
動物実験 | BMOV (0.75-3.0 mmol; intraperitoneal injection; twice weekly; for 6 weeks; Male C57BL/6J mice) treatment ameliorates the metabolic phenotype, as evidenced by reduced body weight, improved insulin sensitivity and glucose tolerance. |
別名 | BMOV, Bis maltolato oxovanadium,Bis(maltolato)oxovanadium (IV),bis maltolato oxo vanadium, Bis(maltolato)oxovanadium (IV) |
分子量 | 317.15 |
分子式 | C12H10O7V |
CAS No. | 38213-69-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 20 mg/mL (63.06 mM)
You can also refer to dose conversion for different animals. 詳細
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Bis(maltolato)oxovanadium(IV) 38213-69-3 Metabolism Others Phosphatase type-2 inhibit SHP2 Inhibitor BMOV phenotype metabolic Bis(maltolato)oxovanadium SHP-1 HCPTPA uptake glucose HPTPβ Bis maltolato oxovanadium,Bis(maltolato)oxovanadium (IV),bis maltolato oxo vanadium insulin Bis(maltolato)oxovanadium (IV) PTP PTP1B diabetes inhibitor