| T7544 |
Fucoidan
|
|
Others
|
|
Fucoidan is found in various species of brown seaweed and algae,with anticancer, antiviral, neuroprotective, immune-modulating. |
| T2210 |
Genipin
|
(+)-Genipin |
Others
,
Autophagy
|
|
Genipin ((+)-Genipin), an active aglycone derived from an iridoid glycoside called geniposide, is found in the fruit of Gardenia jasminoides Ellis. |
| TN1418 |
Azaleatin
|
|
DPP-4
|
|
Azaleatin is a natural product from Rhododendron simsii. Azaleatin is a dipeptidyl peptidase-IV inhibitor. Azaleatin can be used for type-2 diabetes and obesity studies. |
| T7132 |
(Rac)-Brassinazole
|
BRASSINAZOLE |
P450
|
|
(Rac)-Brassinazole are a class of phytohormones with essential roles in plant growth and development, including the promotion of stem elongation and cell division. Brassinazole is a triazole-type brassinosteroid biosynth... |
| T20587 |
2-Acetonaphthone
|
beta-Acetylnaphthalene,beta-Acetonaphthalene,2Acetylnaphthalene,2-Acetylnaphthalene,2 Acetylnaphthalene,beta-Naphthyl methyl ketone |
Endogenous Metabolite
|
|
2-Acetonaphthone (beta-Naphthyl methyl ketone) is a fragrance, anticonvulsant, and antimicrobial agent. It has an onion type flavor and a sulfurous type odor. |
| T4948 |
Potassium 2-hydroxy-2-methylsuccinate
|
(±)-Potassium citramalate monohydrate,(±)-2-Hydroxy-2-methylsuccinic acid dipotassium salt |
Others
,
Endogenous Metabolite
|
|
Potassium 2-hydroxy-2-methylsuccinate ((±)-2-Hydroxy-2-methylsuccinic acid dipotassium salt) is a type of endogenous metabolite. |
| TCS1857 |
2-Phenylacetaldehyde
|
Phenylacetaldehyde,Benzeneacetaldehyde,Phenylethanal,Hyacinthin |
Others
,
Endogenous Metabolite
|
|
2-Phenylacetaldehyde (Hyacinthin) is a type of endogenous metabolite. 2-Phenylacetaldehyde is a perfumery and flavouring ingredient. |
| T3524 |
Halofuginone hydrobromide
|
Tempostatin,RU-19110 (hydrobromide),Stenorol |
Others
,
Calcium Channel
,
DNA/RNA Synthesis
,
Sodium Channel
,
Parasite
,
TGF-beta/Smad
|
|
Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor ce... |
| T13280 |
Valerylcarnitine
|
VALERYL-L-CARNITINE |
Endogenous Metabolite
|
|
Valerylcarnitine (VALERYL-L-CARNITINE) is a short-chain fatty acid used in the study of type 2 diabetes. |
| T2S1992 |
Perillartine
|
Perilla sugar,Peryllartine,DL-Perillartine |
Others
,
Endogenous Metabolite
|
|
Perillartine (DL-Perillartine) is a sweetener. Perillartine activates the taste receptor type 1 member 2 (Tas1r2) subunit in a species-dependent manner. |
| T3829 |
Ginsenoside F3
|
|
Others
,
IFNAR
,
Interleukin
|
|
Ginsenoside-F3 has immunoenhancing activity by regulating production and gene expression of type 1, type 2 cytokines in murine spleen cells. Ginsenoside-F3 enhances the NF-kappaB DNA binding activity induced by ConA in m... |
| T3S1916 |
Heteroclitin D
|
|
Calcium Channel
|
|
1. Heteroclitin D can inhibit L-type calcium channels. 2. Heteroclitin D might be a valuable antitumor promoter or chemopreventor. |
| T17303 |
α-Cyclodextrin
|
Alfadex,NSC269470,NSC 269470,NSC-269470 |
Others
|
|
α-Cyclodextrin (Alfadex) is a soluble fiber derived from corn and has beneficial effects on weight management in obese individuals with type 2 diabetes. |
| T4322 |
2-Hydroxybutyric acid
|
α-Hydroxybutyric acid |
Endogenous Metabolite
|
|
2-Hydroxybutyric acid (α-Hydroxybutyric acid) is a product of protein metabolism and a biomarker for type 2 diabetes and pre-eclampsia. |
| T0461L |
Berberine sulfate
|
AI3-61947,Berberin sulfate,Berberine sulphate,Berberal |
|
|
|
| T7846 |
Aegeline
|
|
Others
,
Antifungal
|
|
Aegeline is an alkaloidal-amide, isolated from the leaves of Aegle marmelos and have shown antihyperglycemic as well as antidyslipidemic activities in the validated animal models of type 2 diabetes mellitus. |
| TN2277 |
Torachrysone-8-O-b-D-glucoside
|
Torachrysone 8-O-glucoside |
Antifection
|
|
Torachrysone-8-O-b-D-glucoside shows alpha-glucosidase inhibitory activities, it may be used for the management of type 2 diabetes. |
| T5273 |
2-Hydroxy-3-methylbutanoic acid
|
2-Hydroxy-3-methylbutyric acid,2-Hydroxyisovaleric Acid,(±)-2-Hydroxyisopentanoic Acid |
Others
,
Endogenous Metabolite
|
|
2-Hydroxy-3-methylbutanoic acid ((±)-2-Hydroxyisopentanoic Acid) is a metabolite found in the urine of patients with phenylketonuria, methylmalonic acidemia, propionic acidemia, 3-ketothiolase deficiency, isovaleric acid... |
| T4716 |
Pyrrole-2-carboxylic acid
|
2-Pyrrolecarboxylic acid,Minaline |
Endogenous Metabolite
|
|
Pyrrole-2-carboxylic acid (Minaline) was first identified as a degradation product of sialic acids, then as a derivative of the oxidation of the D-hydroxyproline isomers by mammalian D-amino acid oxidase. The latter rela... |
| TN1475 |
Caulophyllogenin
|
Segetalic acid |
IL Receptor
,
TNF
,
PPAR
,
Immunology/Inflammation related
|
|
Caulophyllogenin is a partial PPARγ agonist (EC50 = 12.6 μM) derived from the stem bark of Kalopanax pictus (Araliaceae). Caulophyllogenin inhibits pro-inflammatory cytokine secretion and can be used in studies about the... |
| TN1488 |
Chrysin 6-C-glucoside 8-C-arabinoside
|
|
Others
|
|
Chrysin 6-C-glucoside 8-C-arabinoside and Chrysin-6-C-arabinosyl-8-C-glucoside are α±-glucosidase inhibitors, α±-glucosidase inhibitors are widely used in the treatment of type 2 diabetes. |
| TN1487 |
Chrysin 6-C-arabinoside 8-C-glucoside
|
|
Others
|
|
Chrysin 6-C-arabinoside 8-C-glucoside and chrysin-6-C-glucosyl-8-C-arabinoside are α±-glucosidase inhibitors, α±-glucosidase inhibitors are widely used in the treatment of type 2 diabetes. |
| T16442 |
PCO371
|
2,4-Imidazolidinedione, 1-(3,5-dimethyl-4-(2-((4-oxo-2-(4-(trifluoromethoxy)phenyl)-1,3,8-triazaspiro(4.5)dec-1-en-8-yl)sulfonyl)ethyl)phenyl)-5,5-dimethyl- |
Thyroid hormone receptor(THR)
|
|
PCO371 (2,4-Imidazolidinedione, 1-(3,5-dimethyl-4-(2-((4-oxo-2-(4-(trifluoromethoxy)phenyl)-1,3,8-triazaspiro(4.5)dec-1-en-8-yl)sulfonyl)ethyl)phenyl)-5,5-dimethyl-) is an orally active full agonist of parathyroid hormon... |
| TN1132 |
Procyanidin A2
|
|
IL Receptor
,
TNF
,
transporter
,
Antibacterial
|
|
Procyanidin A2 is a potential precursor of 5-(3',4'-dihydroxyphenyl)-γ-valerolactone, exhibits antioxidant, anti-inflammary, anti-hyperglycemia, and anti-type 2 diabetes activities. Procyanidin A2 demonstrates liver cell... |
| T25253 |
Cinnamtannin B-1
|
Cinnamtannin B1 (constituent of cinnamomum verum bark),LDN 0022358,LDN-0022358,LDN0022358 |
Antioxidant
,
COX
|
|
Cinnamtannin B-1 (LDN 0022358) is an A-type proanthocyanidin contained in several plant species such as Vaccinium vitis-idaea, Laurus nobilis L., Cinnamomum zeylanicum, and Lindera umbellata. It is a potent antioxidant a... |
| T5S0620 |
3-Dehydrotrametenolic acid
|
Dehydrotrametenolic acid |
Apoptosis
,
Others
,
Dehydrogenase
|
|
1. 3-Dehydrotrametenolic acid can be a potential anticancer agent against H-ras transformed tumor. 2. Dehydrotrametenolic acid is a promising candidate for a new type of insulin-sensitizing drug. |
| T5S0384 |
Rhapontin
|
Ponticin,Rhaponiticin,Rhaponticin,Rhapontigenin glucoside |
Apoptosis
,
Others
|
|
1. Rhapontin (Ponticin) can alleviate liver steatosis and improve blood glucose and lipid profiles in KK/Ay diabetic mice, indicates that rhaponticin has a noticeable antidiabetic effect and could be potentially used as ... |
| T3394 |
Timosaponin BII
|
Prototimosaponin A III |
Beta Amyloid
,
Others
,
BACE
|
|
Timosaponin BII (Prototimosaponin A III) has anti-dementia activity and may be useful for the treatment of type 2 diabetes. Timosaponin BII has antioxidant activity, can inhibit the up-regulation of BACE1 and reduced the... |
| T1273 |
Diacerein
|
Diacerhein,Fisiodar,Diacetylrhein |
IL Receptor
,
Interleukin
|
|
Diacerein (Fisiodar) is a prodrug which is metabolized to rhein. It is currently approved in France for the treatment of osteoarthritis although the use of diacerein is restricted due to the side effects including sevre ... |
| T2S1792 |
Lycobetaine
|
Ungeremine |
Antibacterial
|
|
1. Lycobetaine (Ungeremine) is a potential biofungicide against Penicillium roqueforti and Aspergillus niger.2. Lycobetaine have strong antibacterial activity against Flavobacterium columnare . 3. Lycobetaine effectively... |
| TCS0102 |
Pulegone
|
(+)-Pulegone |
Calcium Channel
,
Endogenous Metabolite
,
TRP/TRPV Channel
|
|
1. Pulegone ((+)-Pulegone) has cytotoxicity followed by regenerative cell proliferation is the MOA for Pulegone-induced urothelial tumors in female rats. 2. Pulegone induces a verapamil-sensitive psychostimulant effect t... |
| T5303 |
Isethionic acid sodium salt
|
Sodium isethionate |
Others
,
Endogenous Metabolite
|
|
Isethionic acid sodium salt (Sodium isethionate) is an organosulfur compound containing a short chain alkane sulfonate linked to a hydroxyl group. Mammals are able to endogenously synthesize Isethionic acid sodium salt v... |
| T6S1885 |
Benzoylmesaconine
|
Mesaconine 14-benzoate |
Others
|
|
Benzoylmesaconine (Mesaconine 14-benzoate) is the most abundant component of Wutou decoction, which is widely used in China because of its therapeutic effect on rheumatoid arthritis. Benzoylmesconine has analgesic activi... |
| T10024 |
1-Octanol
|
Octanol |
Calcium Channel
,
Endogenous Metabolite
|
|
1-Octanol, a saturated fatty alcohol, functions as an inhibitor of T-type calcium channels (T-channels), showing an inhibitory concentration (IC50) of 4 μM for native T-currents[1]. Additionally, 1-Octanol is recognized ... |
| T6S0659 |
Rhynchophylline
|
Rhynchophyllin,Rhyncophylline,Mitrinermine,Mitrinermin |
Calcium Channel
,
NF-κB
|
|
1. Rhynchophylline (Mitrinermine) can protect against ischemic damage, probably via regulating the Akt/mTOR pathway. 2. Rhynchophylline can protect against glutamate-induced neuronal death, can inhibit MA impairment in c... |
| T3822 |
Bellidifolin
|
Bellidifoline,Bellidifolium |
Others
,
HIV Protease
|
|
Bellidifolin (Bellidifoline) has anti-oxidation, hepatoprotective, anti-inflammatory and antitumor actions, it may contribute to the protective effects associated with nerve injury initiated by hypoxia by mechanisms rela... |
| T6S1699 |
Shogaol
|
[6]-Shogaol,6-Shogaol |
Lipoxygenase
,
Autophagy
|
|
1. 6-Shogaol (6-Shogaol) has antipyretic and analgesic effects in addition to inhibitory effect on lipoxygenase activity. 2. 6-shogaol has anti-inflammatory property, reduces the inflammatory response and protected the f... |
| T2973 |
Astragaloside IV
|
AST-IV,AS-IV |
MMP
,
ERK
,
Estrogen/progestogen Receptor
,
JNK
|
|
Astragaloside IV (AS-IV), an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cel... |
| T5S0018 |
Betulonic acid
|
(+)-Betulonic acid,Betunolic acid,Liquidambaric acid |
Parasite
,
HSV
|
|
1. Betulonic acid (Liquidambaric acid) amide stimulated the regenerative response in hepatocytes under conditions of combined toxic exposure and promoted recovery of their qualitative and quantitative characteristics, wh... |
| T2940 |
6-Hydroxyflavone
|
6-HF |
GABA Receptor
|
|
6-Hydroxyflavone (6-HF) is a noncompetitive inhibitors of cytochrome P450 2C9. It is a flavone, a type of chemical compound. It is reported in leaves of Barleria prionitis Linn. (a common Acanthaceae from India). 6-Hydro... |
| T3417 |
Amentoflavone
|
Didemethyl-ginkgetin,Amenthoflavone,3',8''-Biapigenin |
Apoptosis
,
P450
,
Phospholipase
,
Reactive Oxygen Species
,
Opioid Receptor
,
COX
,
Antibacterial
,
RSV
,
Antifungal
|
|
Amentoflavone (3',8''-Biapigenin), as a potent inhibitor of CYP3A4 and CYP2C9, can interact with many other medications. CYP3A4 and CYP2C9 are proteins used for drug metabolism in the body. Amentoflavone also is an inhib... |
| T2S1865 |
Octyl gallate
|
Gallic acid octyl ester,n-Octylgallate,Octyl 3,4,5-trihydroxybenzoate,Progallin O,Stabilizer GA-8 |
Antioxidant
,
Influenza Virus
,
Reactive Oxygen Species
,
Antibacterial
,
Antifungal
,
HSV
|
|
1. Octyl Gallate is an antioxidant approved by the US Food and Drug Administration (FDA) as a food additive. 2. Octyl Gallate has antimetastatic activity. 3. Octyl Gallate shows antimicrobial activity against H. pylori, ... |
| TN5131 |
Tetrahydrocannabivarin
|
THCV,delta9-Tetrahydrocannabivarin,CRM,Tetrahydrocannavarin |
Cannabinoid Receptor
|
|
Tetrahydrocannabivarin (CRM) is a neutral cannabis receptor subtype (CB1) receptor antagonist, it can increases neural responding to rewarding and aversive stimuli, this effect profile suggests therapeutic activity in ob... |
| T3S1612 |
Kuwanon G
|
Moracenin B,Kuwanone G |
Phosphatase
,
Antibacterial
,
Bombesin Receptor
,
AChR
,
AChE
,
Glucosidase
|
|
1. Kuwanon G (Moracenin B) as dual inhibitors of PTP1B and α-glucosidase enzymes, as well as insulin sensitizers, it may potentially be utilized as an effective treatment for Type II diabetes mellitus. 2. Kuwanon G has a... |
| T4723 |
D-Tagatose
|
D-(-)-Tagatose,d-tagatos |
Others
,
Endogenous Metabolite
|
|
D-Tagatose (D-(-)-Tagatose), a rare natural hexoketose, is an isomer of d-galactose. D-Tagatose occurs naturally in Sterculia setigera gum, and it is also found in small quantities in various foods such as sterilized and... |
| T8274 |
3-Methyl-L-histidine
|
|
Endogenous Metabolite
|
|
3-Methylhistidine belongs to the class of organic compounds known as histidine and derivatives. Histidine and derivatives are compounds containing cysteine or a derivative thereof resulting from reaction of cysteine at t... |
| T29360 |
2-Nonanone
|
2Nonanone,Ketone, heptyl methyl,Heptyl methyl ketone,2 Nonanone |
|
|
2-Nonanone is a flavor and fragrance agent with a fruity type odor and a cheesy type flavor. |
| T27281 |
Eritoran Tetrasodium
|
B 1287,E 5564,B-1287,E5564,B1287,E-5564 |
|
|
Eritoran Tetrasodium, a TLR4 receptor antagonist, is used potentially for the treatment of type 2 diabetes. |
| T83262 |
6-Methoxy-2-[2-(3′-methoxyphenyl)ethyl]chromone
|
|
|
|
6-Methoxy-2-[2-(3'-methoxyphenyl)ethyl]chromone, designated as compound 12, is a type of chromone [1]. |
| TN5234 |
Vindorosine
|
|
Calcium Channel
,
Sodium Channel
|
|
Vindorosine has blood vessel relaxation effect, possible underlying mechanisms involving the inhibition of Ca(2+) entry via L-type Ca(2+) channels in vascular smooth muscles. |
