Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Pentamidine dihydrochloride (MP-601205 dihydrochloride) is an aromatic diamidine agent with activity against a number of microorganisms including protozoa (Trypanosoma brucei, Leishmania spp., and Babesia spp.) and fungi (Pneumocystis jirovecii). Pentamidine dihydrochloride is a potent and selective protein tyrosine phosphatases and phosphatase of regenerating liver inhibitor. Pentamidine dihydrochloride inhibits parasite Leishmania infantum with an IC50 of 2.5 μM.
説明 | Pentamidine dihydrochloride (MP-601205 dihydrochloride) is an aromatic diamidine agent with activity against a number of microorganisms including protozoa (Trypanosoma brucei, Leishmania spp., and Babesia spp.) and fungi (Pneumocystis jirovecii). Pentamidine dihydrochloride is a potent and selective protein tyrosine phosphatases and phosphatase of regenerating liver inhibitor. Pentamidine dihydrochloride inhibits parasite Leishmania infantum with an IC50 of 2.5 μM. |
ターゲット&IC50 | Leishmania infantum:2.5 μM |
In vitro | Pentamidine at its therapeutic doses inhibited recombinant PRL phosphatases in vitro and inactivated ectopically expressed PRLs in NIH3T3 transfectants with an effective duration more than 24 h after a pulse cell treatment[3]. |
In vivo | Pentamidine at a tolerable dose markedly inhibited the growth of WM9 human melanoma tumors in nude mice coincident with the induction of tumor cell necrosis and is capable of inactivating ectopically expressed PRL-2 in the cancer cells[3]. |
別名 | MP-601205 dihydrochloride |
分子量 | 413.34 |
分子式 | C19H26Cl2N4O2 |
CAS No. | 50357-45-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 36 mg/ml (87.10 mM)
You can also refer to dose conversion for different animals. 詳細
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Pentamidine dihydrochloride 50357-45-4 Metabolism Microbiology/Virology Antibiotic Phosphatase Parasite Antifungal Antibacterial PTP1B Pneumocystis Pentamidine MP601205 antitumor Inhibitor Kidney carinii Bacterial cell-cycle pneumonia inhibit MP 601205 MP-601205 DNA MP 601205 Dihydrochloride MP601205 Dihydrochloride Pentamidine Dihydrochloride biosynthetics MP-601205 Dihydrochloride Fungal arrest MP-601205 dihydrochloride inhibitor