Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Blarcamesine hydrochloride (AVex-73 hydrochloride) is a Sigma-1 Receptor agonist (IC50: 860 nM).
説明 | Blarcamesine hydrochloride (AVex-73 hydrochloride) is a Sigma-1 Receptor agonist (IC50: 860 nM). |
ターゲット&IC50 | σ1:860 nM |
In vivo | The pretreatment of Anavex 2-73 (1/3 mg/kg) dose-dependently reduces the scopolamine-induced alternation deficit. The pretreatment with Anavex 2-73 (>0.3 mg/kg) dose-dependently and significantly attenuates the impairments of step-through latency[1]. The Anavex 2-73 (1?mg/kg) dose-dependently blocks the recognition memory deficit. One day after injections, the significant Aβ25-35-induced decrease in Akt phosphorylation is significantly attenuated by Anavex 2-73 (0.1/1?mg/kg). Seven days after injections, Anavex 2-73 attenuates the decrease in Ser9 phosphorylation induced by the peptide (0.3/1?mg/kg)[2]. |
動物実験 | Drugs (including Anavex 2-73) are solubilized in physiological saline at the concentration of 5?mg/mL.Male mice aged 7-9 weeks and weighing 32±2?g are used. Drugs (including Anavex 2-73) are brought up to each dose by dilution and injected in a volume of 100?μL/20?g body weight. Animals are used between days 1 and 9 after i.c.v. injections for behavioral testing or killed before biochemical measures. |
別名 | Anavex 2-73, AVex-73 hydrochloride, AE-37 hydrochloride |
分子量 | 317.85 |
分子式 | C19H24ClNO |
CAS No. | 195615-84-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (173.04 mM)
You can also refer to dose conversion for different animals. 詳細
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Blarcamesine hydrochloride 195615-84-0 GPCR/G Protein Sigma receptor AE37 Hydrochloride Anavex 2-73 AVex-73 hydrochloride AE-37 Hydrochloride AE-37 hydrochloride Inhibitor AVex-73 Hydrochloride Blarcamesine Blarcamesine Hydrochloride inhibit AE 37 Hydrochloride Sigma Receptor inhibitor