Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Buflomedil hydrochloride (Fonzylane), a vasodilator, is used in therapy of claudication or the symptoms of the peripheral arterial disease.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
100 mg | 在庫あり | ¥ 13,500 | |||
500 mg | 在庫あり | ¥ 21,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 11,500 |
説明 | Buflomedil hydrochloride (Fonzylane), a vasodilator, is used in therapy of claudication or the symptoms of the peripheral arterial disease. |
In vitro | Buflomedil enhances intracellular cAMP levels in human keratinocytes, either secondary to adenyl-cyclase stimulation (BC) or phosphodiesterase inhibition (PTX). Buflomedil diminishes release of TPA-induced TNF-alpha and IL-8 in keratinocytes; in the case of IL-8, this inhibition may occur to transcriptional level. At the micromolar level, Buflomedil notably inhibits epinephrine-induced aggregation. Buflomedil leads to a weak inhibition of collagen- and ADP-induced aggregation. Buflomedil inhibits grainy secretion and the interaction of fibrinogen with its receptor on platelet. the capillary perfusion is improved by Buflomedil hypochloride in such related situations, evoking a possible effect upon neutrophils. Buflomedil Completely inhibits adhesion of histamine related neutrophil (flow system) and partially inhibits adhesion after IL-1-4 hours (flow and stable systems). Buflomedil lowers the hypoxia-induced neutrophil adhesion and expression of P-selectin at the surface of endothelial cells. |
別名 | Buflomedil HCl, Fonzylane, Loftyl |
分子量 | 343.85 |
分子式 | C17H26ClNO4 |
CAS No. | 35543-24-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 7 mg/mL (20.35 mM)
H2O: 63 mg/mL (183.2 mM)
DMSO: 50 mg/mL (145.41 mM)
You can also refer to dose conversion for different animals. 詳細
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