Powder: -20°C for 3 years | In solvent: -80°C for 1 year
C 021 dihydrochloride is a potent CCR4 antagonist. C-021 (4-Quinazolinamine, 2-[1,4'-bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-) dihydrochloride potently inhibits functional chemotaxis in humans and mice with IC50s of 140 nM and 39 nM, respectively. It effectively prevents human CCL22-derived [35S]GTPγS from binding to the receptor (IC50: 18 nM).
説明 | C 021 dihydrochloride is a potent CCR4 antagonist. C-021 (4-Quinazolinamine, 2-[1,4'-bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-) dihydrochloride potently inhibits functional chemotaxis in humans and mice with IC50s of 140 nM and 39 nM, respectively. It effectively prevents human CCL22-derived [35S]GTPγS from binding to the receptor (IC50: 18 nM). |
ターゲット&IC50 | CCR4:140 nM (human), CCR4:39 nM(mice) |
別名 | 4-Quinazolinamine, 2-[1,4'-bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy- |
分子量 | 467.65 |
分子式 | C27H41N5O2 |
CAS No. | 864289-85-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 9 mg/mL (19.24 mM)
You can also refer to dose conversion for different animals. 詳細
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C-021 864289-85-0 Immunology/Inflammation Microbiology/Virology CCR Inhibitor inhibit CC chemokine receptor CCL22 GTPγS chemotaxis C021 4-Quinazolinamine, 2-[1,4'-bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy- CCR4 C 021 inhibitor