|
T13015 |
STING agonist-4
|
|
STING
|
|
STING agonist-4 is an agonist of stimulator of Interferon Genes (STING) receptor(IC50 of 20 nM). |
|
T7329 |
C-178
|
|
STING
|
|
C-178 is a covalent inhibitor of STING, binds to Cys91 on STING to block its palmitoylation and prevents recruitment and phosphorylation of TBK1 in HEK293T cells. |
|
T13613 |
ChX710
|
|
STING
|
|
ChX710 activates the type I interferon response to cytosolic DNA by priming specific Interferon-Stimulated Genes (ISGs), inducing the ISRE promoter sequence, and facilitating the phosphorylation of Interferon Regulatory ... |
|
T9853 |
STING activator Compound 53
|
|
STING
|
|
STING activator Compound 53 based on an oxindole core structure demonstrated robust on-target functional activation of STING (human EC50 185 nM) in immortalised and primary cells and a cytokine induction fingerprint cons... |
|
T6919 |
Omaveloxolone
|
RTA-408 |
Apoptosis
,
Others
,
Nrf2
,
STING
|
|
Omaveloxolone (RTA-408) (RTA-408) is a synthetic triterpenoid that activates the cytoprotective transcription factor Nrf2 and inhibits NF-κB signaling. Phase 2. |
|
T9554 |
SN-008
|
|
STING
|
|
SN-008 is a less active analog SN-011 which is a STING antagonist. SN-008 can be used as a negative control. |
|
T5674 |
H-151
|
|
STING
|
|
H-151 is a highly potent and selective STING antagonist. H-151 covalently binds to Cys91 of STING and inhibits palmitoylation of Cys91, thereby inhibiting STING activity. H-151 can be used in the study of autoinflammator... |
|
T8655 |
SR-717
|
|
STING
|
|
SR-717 is a cGAMP analog, a non-nucleoside STING agonist that induces a "closed" activation conformation of STING. SR-717 has antitumor activity and promotes activation of immune cells and cross-presentation of antigens. |
|
T9029 |
STING-IN-3
|
C-171 |
STING
|
|
STING-IN-3 (C-171) is an inhibitor of stimulator of interferon genes (STING). It binds to STING, inhibits its palmitoylation, and prevents the recruitment and phosphorylation of TBK1. |
|
T8798 |
MSA-2
|
|
STING
|
|
MSA-2 is a potent and orally available non-nucleotide STING agonist. |
|
T5516 |
DiABZI STING agonist-1 trihydrochloride
|
|
STING
|
|
diABZI STING agonist-1 (trihydrochloride) is stimulator of interferon genes (STING) receptor agonist. |
|
T5154 |
C-176
|
C176,STING inhibitor 1 |
STING
|
|
C-176 (STING inhibitor 1) is a strong, covalent mouse STING inhibitor |
|
T8328 |
STING agonist-1
|
G10 |
Virus Protease
,
STING
|
|
STING agonist-1 (G10) is a human-specific STING agonist,elicits antiviral activity against emerging Alphaviruses. |
|
T9028 |
STING-IN-2
|
C-170 |
STING
|
|
STING-IN-2 (C-170) is a potent and covalent inhibitor of STING. C-170 efficiently inhibits both mouse STING (mmSTING) and human STING (hsSTING). It can be used for autoinflammatory disease research. |
|
T7081 |
CCCP
|
Carbonyl Cyanide m-Chlorophenylhydrazone,Carbonyl cyanide 3-chlorophenylhydrazone |
Apoptosis
,
IκB/IKK
,
COX
,
Mitochondrial Metabolism
,
STING
,
IFNAR
,
Antibacterial
|
|
CCCP (Carbonyl Cyanide m-Chlorophenylhydrazone) is an oxidative phosphorylation (OXPHOS) inhibitor and mitochondrial proton carrier uncoupler. CCCP inhibits the activation of STING and its downstream signaling molecules ... |
|
T9137 |
SN-011
|
[1,1'-Biphenyl]-4-carboxamide, N-[3-[[(4-fluorophenyl)sulfonyl]amino]-4-hydroxyphenyl]-,GUN35901 |
STING
|
|
SN-011 (GUN35901) is a STING inhibitor, which inhibited the activation of the STING signal pathway and to prevent or treat a STING- mediated disease. It is a demethyl analogue of DUN99845. |
|
T10252L2 |
ADU-S100 ammonium salt
|
ML RR-S2 CDA ammonium salt,MIW815 ammonium salt |
STING
|
|
|
|
T6273 |
Vadimezan
|
DMXAA,5,6-Dimethylxanthenone-4-acetic Acid,NSC 640488,ASA-404 |
Influenza Virus
,
VDA
,
STING
,
IFNAR
|
|
Vadimezan (DMXAA) is a vascular disrupting agent, a murine STING agonist, and an inducer of cytokines such as type I IFN. Vadimezan has antitumor activity and induces a rapid cessation of blood flow in tumors without aff... |
|
T68087 |
Inaperisone
|
|
Others
|
|
Inaperisone is a novel centrally acting muscle relaxant that inhibits the voiding reflex. Inaperisone may inhibit the voiding reflex by acting indirectly on GABAB receptors in the brainstem. |
|
T11035 |
DiABZI STING agonist-1 (Tautomerism)
|
diABZI STING agonist (Compound 3) |
STING
|
|
diABZI STING agonist-1 (Tautomerism) (diABZI STING agonist (Compound 3)) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively. |
|
T0511 |
Tolperisone hydrochloride
|
Muscalm,Midocalm,Tolperisone HCl |
Sodium Channel
|
|
Tolperisone hydrochloride (Muscalm), a centrally acting muscle relaxant, is used in the therapy of pathologically increased tone of the cross-striated muscle resulted by neurological diseases (damage of the encephalomyel... |
|
T5005 |
Eperisone hydrochloride
|
|
Others
|
|
Eperisone is a skeletal muscle relaxant and a spasmolytic agent related structurally to Tolperisone. |
|
T8441 |
Lerisetron
|
|
5-HT Receptor
|
|
Lerisetron is an antagonist of serotonin type 3 (5-HT3) receptor, with antiemetic activity. |
|
T70489 |
Enerisant HCl
|
|
P450
,
Histamine Receptor
|
|
Enerisant HCl is a novel potent and selective histamine H3 receptor antagonist, a substrate for P-gp, mediated by cytochrome P450 (CYP) and transporter proteins. |
|
T28778 |
Silperisone HCl
|
RGH5002,SILA336,RGH-5002,Silperisone hydrochloride,SILA-336 |
|
|
Silperisone HCl (RGH-5002) blocks sodium and calcium channels in cells, decreases excitability and contractility of muscle cells, reduces peripheral tone, and acts as a muscle relaxant and peripheral vasodilator. Silperi... |
|
T28159 |
Nerisopam
|
EGIS-6775,GYKI 52322,GYKI52322,EGIS6775,GYKI-52322 |
GABA Receptor
|
|
Nerisopam is an agonist of gamma-aminobutyric acid (GABA) receptor. |
|
T67828 |
Enerisant
|
TS-091 |
Histamine Receptor
|
|
Enerisant (TS-091) is an orally active, selective and potent histamine H3 receptor antagonist that modulates histamine H3 receptors in mice in a dose-dependent manner.Enerisant promotes pro-cognitive effects and reverses... |
|
T28160 |
Nerispirdine HCl
|
HP-184,HP 184,Nerispirdine hydrochloride,HP184 |
|
|
Nerispirdine is a acetylcholine release enhancer, sodium channel blocker and K(V) 2.1 channel blocker. Nerispirdine inhibits voltage-dependent Na(+) channel currents recorded from human SH-SY5Y cells with an IC(50) of 11... |
|
T32561 |
Lanperisone
|
|
|
|
Lanperisone is a muscle relaxant. |
|
T21077 |
Tolperisone free base
|
Mydeton,Atmosgen free base,Mideton,Menopatol,Besnoline free base,Mydocalm |
|
|
Tolperisone free base, a centrally acting muscle relaxant, has been used for the symptomatic treatment of spasticity and muscle spasm. |
|
T124126 |
Asteriscunolide A
|
|
|
|
Asteriscunolide A is a useful organic compound for research related to life sciences and the catalog number is T124126. |
|
T40744 |
Eperisone
|
|
|
|
Eperisone is a centrally acting muscle relaxant and antispastic agent utilized in the treatment of conditions distinguished by muscle stiffness and pain. Its mechanism of action involves the relaxation of skeletal muscle... |
|
T125924 |
Pterisolic acid B
|
|
|
|
Pterisolic acid B is a useful organic compound for research related to life sciences and the catalog number is T125924. |
|
T125921 |
Monnieriside A
|
|
|
|
Monnieriside A is a useful organic compound for research related to life sciences and the catalog number is T125921. |
|
T71281 |
Nerispirdine
|
|
|
|
Nerispirdine is a biochemical that inhibits batrachotoxin binding to voltage-dependent sodium channels. |
|
T71356 |
Lanperisone HCl
|
|
|
|
Lanperisone, also known as NK433, is a muscle relaxant. NK433 inhibited the facilitation of the flexor reflex mediated by group II afferent fibers that was induced by intrathecal administration of noradrenaline-HCl. NK43... |
|
T81509 |
Perisulfakinin
|
|
|
|
Perisulfakinin, a satiety-signaling neuropeptide, suppresses the activity of neurons that stimulate general activity [1]. |
|
T125082 |
Pierisformoside B
|
|
|
|
Pierisformoside B is a useful organic compound for research related to life sciences. The catalog number is T125082 and the CAS number is 308335-44-6. |
