Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CDK9-IN-7 is a highly selective and orally active CDK9/cyclin T inhibitor (IC50: 11 nM), which exhibits more potent over other CDKs (CDK4/cyclinD: 148 nM; CDK6/cyclinD: 145 nM).
説明 | CDK9-IN-7 is a highly selective and orally active CDK9/cyclin T inhibitor (IC50: 11 nM), which exhibits more potent over other CDKs (CDK4/cyclinD: 148 nM; CDK6/cyclinD: 145 nM). |
ターゲット&IC50 | CDK6-CyclinD:145 nM, CDK4-CyclinD:148 nM, CDK9-CyclinT1:11 nM |
In vitro | CDK9-IN-7 (compound 21e) displays exceptional potency against NSCLC cell lines, especially A549 and H1299 with IC50 values less than 0.5 µM. In the drug-resistant NSCLC cell line H1975, CDK9-IN-7 also exhibits good inhibition potency (IC50: 0.837 µM)[1]. |
分子量 | 547.71 |
分子式 | C29H37N7O2S |
CAS No. | 2369981-71-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 56.7 mg/mL (103.5 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
CDK9-IN-7 2369981-71-3 Cell Cycle/Checkpoint CDK CDK-9-IN-7 CDK9IN7 CDK9 IN 7 Inhibitor inhibitor inhibit