Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CL316243 is a highly potent selective agonist of β3-adrenoceptor, with a EC50 of 3 nM. CL316243 is an effective stimulant of adipocyte lipolysis and increases brown adipose tissue thermogenesis and metabolic rate. CL316243 has the potential for the treatment obesity, diabetes and urge urinary incontinence.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 11,000 | |||
5 mg | 在庫あり | ¥ 26,000 | |||
10 mg | 在庫あり | ¥ 39,500 | |||
25 mg | 在庫あり | ¥ 80,000 | |||
50 mg | 在庫あり | ¥ 127,500 | |||
100 mg | 在庫あり | ¥ 204,000 | |||
500 mg | 在庫あり | ¥ 406,500 |
説明 | CL316243 is a highly potent selective agonist of β3-adrenoceptor, with a EC50 of 3 nM. CL316243 is an effective stimulant of adipocyte lipolysis and increases brown adipose tissue thermogenesis and metabolic rate. CL316243 has the potential for the treatment obesity, diabetes and urge urinary incontinence. |
ターゲット&IC50 | β3-adrenoceptor:(EC50)3 nM |
In vitro | CL 316243 displays binding affinities with IC50 values of 1 μM and 0.6 μM for rat soleus muscle and rat heart respectively. CL 316243 inhibits spontaneously contracting, isolated rat detrusor strips in a concentration-dependent manner with a mean concentration inhibiting 50% of the maximal response of 2.65 nM [1]. |
In vivo | CL316243 disodium (subcutaneously injection; 0.1 mg/kg/day; once a day; 1 week) elevates the mRNA and protein expression levels of BAT in UCP1 [2]. |
分子量 | 465.79 |
分子式 | C20H18ClNNa2O7 |
CAS No. | 138908-40-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 80 mg/mL (171.75 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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CL 316243 138908-40-4 GPCR/G Protein Neuroscience Adrenergic Receptor inhibit Inhibitor Beta Receptor CL-316243 CL316243 inhibitor