Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CMPD1 is a non-ATP-competitive p38 MAPK-mediated MK2 phosphorylation inhibitor(apparent Ki (Kiapp): 330 nM).
説明 | CMPD1 is a non-ATP-competitive p38 MAPK-mediated MK2 phosphorylation inhibitor(apparent Ki (Kiapp): 330 nM). |
ターゲット&IC50 | MK2:(Kiapp)330 nM |
In vitro | CMPD1 exhibits selective activity within glioblastoma cells by inhibiting tubulin polymerization[3], crucial for cell division. Contrarily, it does not affect p38 MAPK-mediated phosphorylation of substrates MBP and ATF2, indicating specificity in its action. Furthermore, it induces mitotic arrest and apoptosis in U87 cells[1], highlighting its potential therapeutic implications in targeting cancer cell proliferation and survival. |
分子量 | 349.4 |
分子式 | C22H20FNO2 |
CAS No. | 41179-33-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (157.41 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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CMPD1 41179-33-3 MAPK MAPK activated protein kinase 2 MAP kinase activated protein kinase 2 MAPKAPK2 (MK2) inhibit Mitogen-activated protein kinase activated protein kinase 2 Inhibitor MAPKAP kinase 2 CMPD 1 CMPD-1 inhibitor