Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CRT0066854 hydrochloride is an effective selective atypical PKCs inhibitor. CRT0066854 is against full-length (FL) PKCι, PKCζ, and ROCK-II kinases with IC50 values of 132 nM, 639 nM, and 620 nM, respectively.
説明 | CRT0066854 hydrochloride is an effective selective atypical PKCs inhibitor. CRT0066854 is against full-length (FL) PKCι, PKCζ, and ROCK-II kinases with IC50 values of 132 nM, 639 nM, and 620 nM, respectively. |
ターゲット&IC50 | ROCKII:620 nM, PKCζ:639 nM |
In vitro | CRT0066854 hydrochloride replaces the crucial Asn-Phe-Asp motif, which is part of the adenosine binding pocket and joins with the acidic patch used by the PKC substrate rich in arginine. CRT0066854 hydrochloric acid Salt (0.2-1.2μM; 6 days) can restore polarized morphogenesis. Among the dysplastic H-Ras spheroids, the maximum proportion of PSAL spheroids was 1.2 μM at a lower dose[1]. |
分子量 | 488.48 |
分子式 | C24H27Cl2N5S |
CAS No. | 2250019-91-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (92.12 mM)
You can also refer to dose conversion for different animals. 詳細
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CRT0066854 hydrochloride 2250019-91-9 Cell Cycle/Checkpoint Chromatin/Epigenetic Cytoskeletal Signaling Stem Cells PKC ROCK CRT 0066854 Hydrochloride CRT-0066854 Hydrochloride CRT-0066854 hydrochloride CRT0066854 Hydrochloride Inhibitor inhibitor inhibit